Satoshi Yoshinaga, M.D., Ph.D.
@SatoshiYoshina1
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Psychiatrist studying mammalian brain development
Joined October 2020
6/Huge thanks to our incredible multidisciplinary team @SatoshiYoshina1, @JayShin, @chungchau_hon, @carninci , Kubo-sensei and others.
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5/We show that ILAs play a crucial role in the disrupted brain circuitry of schizophrenia and propose potential targets for novel therapies and morphological markers for histopathological diagnosis.
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4/We also found a negative relationship between ILA processes and GFAP+ cell density in the grey matter with "healthy" aging.
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3/ Further histological investigations showed that interlaminar astrocytes (ILA) in layer 1, which extend long processes into cortical layers, exhibited reduced cell density and abundance of processes in schizophrenia.
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2/ We performed an integrative analysis of spatial and single-nucleus transcriptomics of the anterior cingulate cortex in schizophrenia patients, together with a thorough histological analysis. Our findings highlight significant alterations in glial cells, primarily astrocytes.
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1/ I am happy to share that our latest research paper is now available as a preprint on bioRxiv! 🧠🧬Integrative Transcriptomics Reveals Layer 1 Astrocytes Altered in Schizophrenia https://t.co/iGBhRra75p
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Thrilled to share our latest preprint on how we have been tackling the pathophysiology of schizophrenia, a graveyard of neuropathologists, using spatial transcriptomics. #biorxiv #schizophrenia #spatialtranscriptomics #Visium
https://t.co/sbAN0xnnkl
biorxiv.org
Schizophrenia is one of the most prevalent psychiatric disorders with unclear pathophysiology despite a century-long history of intense research. Schizophrenia affects multiple networks across...
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A wonderful paper has been published on bioRxiv by an excellent anatomy professor. Research on schizophrenia. If you are interested, please check it out. Integrative Transcriptomics Reveals Layer 1 Astrocytes Altered in Schizophrenia
biorxiv.org
Schizophrenia is one of the most prevalent psychiatric disorders with unclear pathophysiology despite a century-long history of intense research. Schizophrenia affects multiple networks across...
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In Vivo Reactive Astrocyte Imaging in Patients With Schizophrenia Using [18F]THK5351
jamanetwork.com
This case-control study investigates the in vivo imaging of reactive astrocytes and their association with positive symptoms in patients with schizophrenia using validated monoamine oxidase B–binding...
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Thrilled to share our latest preprint on how we have been tackling the pathophysiology of schizophrenia, a graveyard of neuropathologists, using spatial transcriptomics. #biorxiv #schizophrenia #spatialtranscriptomics #Visium
https://t.co/sbAN0xnnkl
biorxiv.org
Schizophrenia is one of the most prevalent psychiatric disorders with unclear pathophysiology despite a century-long history of intense research. Schizophrenia affects multiple networks across...
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5月に出たこのLong COVIDのTSPO PET論文は非常に重要。だけど、TSPO PETにおけるVT値の上昇を、病理学的な用語であるグリオーシスと同一視するのは正確ではない。この研究に死後脳による検討結果が含まれてたら話は別だが。 精神科領域で死後脳研究がもっと増えるといいな
Gliosis, especially in ventral striatum and dorsal putamen may reflect injury and/or ongoing inflammation after acute #COVID19 with sequelae of depressive and cognitive symptoms.
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We are very happy to share our paper "Heterozygous Dab1 null mutation disrupts neocortical and hippocampal development" in #eNeuro @SfNJournals. https://t.co/ELJLSruRjn 1/n
eneuro.org
Loss-of-function mutations in Reelin and DAB1 signaling pathways disrupt proper neuronal positioning in the cerebral neocortex and hippocampus, but the underlying molecular mechanisms remain elusive....
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#JNeurosci: @kohneuro @SatoshiYoshina1 et al. @KeioGlobal studied how CLA neurons in mice migrate to form the nuclear structure during development, finding that some CLA neurons migrated radially outward at first, then inward after reaching the surface. https://t.co/71intthUH5
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A new original paper by a distinguished undergraduate student, Ohshima-kun, congratulations! Best of luck on your medical licensing examination nest month! https://t.co/en2Vmn7prl
jneurosci.org
The claustrum (CLA) is a cluster of neurons located between the insular cortex and striatum. Many studies have shown that the CLA plays an important role in higher brain function. Additionally,...
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This explains why reeler and yotari mice show outside-in cortical layer formation. This study also suggests the existence of non-cell autonomous function of Dab1, which helps migration of the later born neurons, highlighting a quality control system of cortical development.
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We provided evidence that Dab1 -/- deep layer neurons below the subplate, when they are in high cell density, become impermissive to the migration of Dab1 -/- superficial layer neurons, which themselves have a potential to migrate past the subplate.
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Several lines of evidence have suggested that the function of Dab1 is cell autonomous. However, we do not know yet if the function of Dab1 is purely cell-autonomous. In this study, we took advantage of versatility of in utero electroporation to directly evaluate this view.
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Although many researchers all over the world have been extensively studying these mice in the last several decades, we do not even know why these mice show outside-in lamination.
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The hallmark of mammalian cortical development is a 6-layered structure, where early born neurons populate deeply and late born neurons superficially. This inside-out lamination is roughly inverted in reeler and yotari mice, in which Reelin and Dab1 is depleted.
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