Wondered how #adipocyte #fat release #lipid via #lipolysis in #fasting, cold exposure? Multi-year @Razanilab effort in @jclinicalinvest by postdoc maven @yushengyeh identifies #lysosome lipolysis (LAL) as major way on par with known cytosolic route (ATGL).

Check out our new commentary on #leucine and role in #CVD #atherosclerosis via #mtor #autophagy. Spearheaded by @XiangyuZ0321, @AliiAjam & @RazaniLab team we discuss next steps in limiting leucine's damage to the #macrophage & the atherosclerotic plaque.

Our work suggests that if trehalose has disease-fighting effects by ingestion, they are likely secondary to other physiological effects and not directly.

#trehalose is still a fascinating dissacharide that works brilliantly by parenteral (i.e. not oral) route to treat many diseases spanning #atherosclerosis, metabolic, & neurodegenerative diseases. It just cannot be ingested and assumed to be effective as suggested in many papers.

News flash #trehalose aficionados: New work by @yushengyeh and @RazaniLab team shows this natural sugar inducing #autophagy #TFEB to treat #obesity #metabolism & other diseases is NOT effective by oral route and KO of gut enzyme #trehalase doesn't help.

Bonanza of cool papers recently on curious BMP #lipids only found in #lysosomes, discovery of degrading enzyme PLA2G15, and role in physiology & disease by labs of @JudithSimcox in @Cell_Metabolism.and @abu_remaileh in @Nature. .

Look who got his 1st corresponding author paper in @theJIDJournal on #tcell MyD88/A20 & psoriatic #arthritis? Congrats Dr. Bahram Razani @BahramRazani, Dermatologist-Scientist extraordinaire @UCSFMedicine. Best wishes as you setup the "other" RazaniLab💪😁.

Timely review of #precisionnutrition as strategy in #CVD #metabolism disease therapy in @NatureMedicine by @MartaGuasch1 @Riudecanyenc & colleagues. Note that uncovering mechanisms linking nutrients to cellular signaling true power of precision #nutrition.

Congratulations to Carlos Cosme (@life_of_carlos), @PittCMU_MSTP student in @RazaniLab @PittVMI for winning this year's Monga Family #Cardiovascular Research Award at #Pathobiology25 #ASIP2025 👏🏼👏🏼

And of course, can't forget to mention the fun of hanging out and enjoying some Chesapeake crab cakes 👌

Great showing by @RazaniLab at #VascularDiscovery25 in Baltimore the past 3 days. Kudos to the efforts of @KathyMartinYale, the entire organizing committee, & @American_Heart for the excellent programming & opportunity to present our work. See you all next year in Bellevue, WA!

Lots to like about work of @DrGregSteinberg lab in @NatMetabolism on #adrenaline stimulating #adipocyte #lipolysis (via ATGL) to activate #macrophage #GDF15 action on brain centers for #anxiety. Adipose-immune-brain axis also relevant to metabolic disease.

Interesting new concepts by @dillinlab in @CellCellPress on #autophagy #aggrephagy in "quiescent" cells actually inducing #lysosome damage that is curbed by #TFEB & UPR response. Novel way of looking at this & excited to see its role in #aging & disease.

Herculean effort by @Polash_23 @DiwanLabWustl & team in @jclinicalinvest showing role of CRYAB & #proteinaggregation in #heartfailure, ischemic #cardiomyopathy. This is beyond role in genetic CM. Congrats also on cool cover! Happy to have collaborated with you over the years 🤝.

Congratulations to our team member, Dr. Xiangyu Zhang @XiangyuZ0321, Assistant Prof. @PittDeptofMed @PittVMI & Core Director of Center for #Immunometabolism: Got DOUBLE awards this week 😱 (@American_Heart Career Development Award & @PLRC_PittLiver P&F Grant). Sky's the limit 💪

RT @the_asci: Spilling the skinny on fat cells!. ASCI member Babak Razani @RazaniLab & team @pitt_medicine discover the process for adaptat….

Nice work in @ImmunityCP by Isidoro Cobo & @UCSDGlassLab showing #macrophage crystalline/particle uptake universally induce #lysosome #transcription program via #AMPK #TFEB independent of #inflammation pathways. Thx for including @RazaniLab in the journey.

We thank all our @RazaniLab members and many collaborators in making this happen 🤝 (@XiangyuZ0321 @kratky_lab @Alicardsdoc @hanrui_zhang @ParthaDuttaLab @StraubLab @LodhiLab include those with Twitter handles).

Lysosomal Acid #Lipase (Lipa/LAL) is upregulated in #AdiposeTissue during #fasting, cold exposure, and even #obesity. When we ablate #adipocyte Lipa/LAL, mice cannot undergo full #lipolysis with difficulty maintaining body temperature in cold. On #highfat diet, they become obese.

Announcing #Pittsburgh Metabolism Consortium. Joint venture by @PittDeptofMed Endocrinology Division, Center for Immunometabolism (CIM), Center for Mitochondrial Medicine (C3M), we aim to connect #metabolism community in @pitt_medicine. Spring seminar series start next week 🤩