David Sancho
@SanchoLab
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Passionate about #immunology. Sensing damaged self, infections & microbiota by DCs and macrophages to ignite innate & adaptive immunity. #Immunometabolism
Professor @CNIC, Madrid, Spain
Joined September 2019
💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. https://t.co/ZazBw50FFC
#OpenAccess at @Nature
@CNIC_CARDIO
#microbiome #CVD
nature.com
Nature - Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the...
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What an amazing and mind blowing talk from @SanchoLab. Thank you so much David for sharing your top science with us! 👍🏼
🎙️ Invited Plenary Lecture 1 — chaired by @Dolmeda 🌟David Sancho: Metabolic control of myeloid cell function 🔶Prof. Sancho leads the Immunobiology Lab at CNIC and is internationally recognized for uncovering new mechanisms of immune cell metabolism. 🌍🔬 #RetreatIIBM_2025
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🎙️ Invited Plenary Lecture 1 — chaired by @Dolmeda 🌟David Sancho: Metabolic control of myeloid cell function 🔶Prof. Sancho leads the Immunobiology Lab at CNIC and is internationally recognized for uncovering new mechanisms of immune cell metabolism. 🌍🔬 #RetreatIIBM_2025
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🌞 Day 2 begins at La Cristalera! Today we welcome 2 Invited Plenary Speakers: 🔶 Prof. David Sancho, @SanchoLab @CNIC_CARDIO 🔶 Prof. Susana Guerrero Salazar, @IGIUMAoficial (University of Málaga @InfoUMA ) Another full day of science, ideas, and inspiring talks ahead! ✨
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#InflammasomePower! How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With Oceane &co we show that chronic oxPAPC signaling drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans!
biorxiv.org
Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli,...
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https://t.co/MGCmGeii6M
@CeronLab es gran científico y 🔝divulgador en @raticosde100cia: La charla más divertida para repasar nuestros >25 años en #inmunología & #inmunoterapia. 🙏 @ERC_Research @AgEInves @FundlaCaixa @CaixaResearch @ContraCancerEs @contracancerINV @CNIC_CARDIO
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🎧 ¿Has escuchado ya el nuevo episodio del #podcast @raticosde100cia en el que el investigador @SanchoLab comenta cómo la #microbiota puede influir en la salud del corazón? 🧠🫀 El líder del laboratorio de #Inmunobiología del @CNIC_CARDIO explica cómo una molécula, el propionato
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Because of a lapse in government funding, PubMed is no longer being updated. Europe PMC is a great alternative and has 8M+ more papers than PubMed. We just added Europe PMC to Chat Academia so researchers can use the most up-to-date database with AI. Check it out 👇
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Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins.
nature.com
Nature - A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.
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You can never forget your first love!! It took me back ~25 years but it was a lot of fun to write (together with Ali Rosen in the lab) this News & Views @NatImmunol for the fantastic story by Maria Toribio and colleagues on the pre-TCR as an immunotherapy target in T cell
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🚨Latest piece from #Saeedi_Lab is out in @atvbahajournals. 💡👉🏻This comment highlights how gut #microbiota-dependent metabolites, #ImP & #PAA, divergent in source but convergent in function, promote #atherosclerosis. #arash_haghikia
@CTECresearch @Unispital_USZ @CardioZurich
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Don't miss out on being a part of this amazing line-up of speakers! Come share your amazing work! Short-talk abstract submission and scholarship deadline is October 29th for the #KSmyeloid26
https://t.co/ZpzTlZULSD
@JennGuerriero @FGinhoux @KeystoneSymp @lai9uan @SanchoLab
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Thanks to the organizers @Fabre_Thomas_89 @shalinhnaik & Charlotte Scott for the fantastic opportunity to discuss our most recent data in this great @KeystoneSymp meeting!!! Looking forward to meeting all the #myeloid community!
An honor to co-organize this symposium @shalinhnaik and Charlotte. Explore emerging research with field leaders @KeystoneSymp Myeloid Cells: Functional Heterogeneity with Therapeutic Promise, this February in Keystone! https://t.co/wb26A3kZmd
#KSMyeloid26
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New in @JACCardioOnc: Peripheral ischemia drives breast cancer progression by reprogramming hematopoiesis toward myeloid-biased inflammation. Vascular injury is not just a bystander — it fuels tumor growth. @CNIC_CARDIO
jacc.org
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#InterferonPower! Thrilled for our latest work @CellCellPress! With @dfrboehmer, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free link 👉 https://t.co/gYwGir0npB
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Hunting for the next key metabolite besides #TMAO driving #atherosclerosis #CVD? Need to read excellent work by @SanchoLab in @Nature implicating gut #microbiota derived "ImP" with possible links to our favorite #macrophage #mtor signaling in the plaque. https://t.co/SYsf9TLVF3
nature.com
Nature - Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the...
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This was so much fun to write, thank you @SwirskiLab and @FGinhoux !! A summary of the many surprising jobs that immune cells do after hours (and it is more than just cleaning up) Immune system influence on physiology | Science
science.org
The immune system’s central function is to maintain homeostasis by guarding the organism against dangerous external and internal stressors. Immunity’s operational toolbox contains diverse processes,...
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🧬2nd Semester 2025 lineup is here! Join us for a new round of cutting-edge immunology seminars from top researchers around the world! Mark your calendar & share! For more info: https://t.co/WVTxwGl3yN
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💥Check out our latest work in @NatureComms We identify a new target to impair DNA repair🧬inducing #senescence and #celldeath through synthetic lethality in combination with cancer therapy🧵 🔗Open access PDF: https://t.co/tazCZgufRN
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Had a great time today on TG8 for rete 8 discussing our @Nature study on #ImidazolePropionate in #Atherosclerosis. Grateful for the opportunity to share our findings in my home country! 🙏👩🔬@CNIC_CARDIO
https://t.co/xg13ziP2yI
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CNIC researcher @annalaura_mstrn spoke on @Rete8News about @Nature study on #ImidazolePropionate and #Atherosclerosis. CNIC is proud of @SanchoLab for this great work. Grateful to share these findings in her home country!
Had a great time today on TG8 for rete 8 discussing our @Nature study on #ImidazolePropionate in #Atherosclerosis. Grateful for the opportunity to share our findings in my home country! 🙏👩🔬@CNIC_CARDIO
https://t.co/xg13ziP2yI
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