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@CircAHA

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Boston, MA
Joined February 2012
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@CircAHA
Circulation
9 months
#ICYMI : EV-AAVs as a novel cardiac gene delivery vector @SusmitaSahooPhD #AHAJournals
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@CircAHA
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9 months
#ICYMI : EV-AAVs as a novel cardiac gene delivery vector @SusmitaSahooPhD #AHAJournals
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@CircAHA
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4 years
Just Published Online: #OnMyMind : #COVID19 , Arrhythmias and Inflammation #AHACOVID19 #AHAJournals @AHAScience
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@CircAHA
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3 years
#Perspective : How should we sequence the treatments for HFrEF? A redefinition of evidence-based medicine #AHAJournals @UoGHeartFailure
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@CircAHA
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6 years
Read the New Universal Definition of MI in Circulation
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@CircAHA
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6 years
Does my patient have HFpEF? How can I make an evidence based diagnosis? Learn More: @yreddyhf
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@CircAHA
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5 months
2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation #AHAJournals
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@CircAHA
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4 years
#WhitePaper : Value of Hemodynamic Monitoring in Patients with Cardiogenic Shock Undergoing Mechanical Circulatory Support #AHAJournals
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@CircAHA
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4 years
#CircECG : A 35 yo woman is admitted for septic shock with group A strep bacteremia and a hand abscess from IVDU. TEE showed a TV vegetation with mild-mod regurgitation. Lung CT showed septic emboli. What is the sign seen on ECG? #AHAJournals
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@CircAHA
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3 years
Just Published: 2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy #AHAJournals @AHAScience
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@CircAHA
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6 years
Cardiorenal syndrome 💔: Recent scientific work identifies fibrosis as a common pathophysiologic feature for this vicious and interrelated cycle. Perhaps this can lead to novel therapeutic targets. Learn more:
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@CircAHA
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1 year
#Editorial : ECMO for Cardiogenic Shock: When to open the Parachute? #AHAJournals
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@CircAHA
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5 years
The multidisciplinary Shock Team approach for the treatment of refractory cardiogenic shock decreased in-hospital and 30-day all-cause mortality | #AHAJournals @JoeTonnaMD @StavrosDrakos @Joseph_Taleb @UofUHealth
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@CircAHA
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4 years
Just Published Online: #InDepthReview : Science and #COVID19 : Implications for the CV System #AHACOVID19 #AHAJournals @AHAScience
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@CircAHA
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3 years
EMBRACE- HF: In patients with HF and CardioMEMS, empagliflozin produced rapid reductions in PA pressures that were amplified over time and appeared to be independent of loop diuretic management #AHAJournals @MkosiborodMD @MichaelNassifMD
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@CircAHA
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5 years
IAPB-SHOCK II Trial: 6 year results confirm no longer term benefit of #IABP in STEMI w/cardiogenic shock; high (~66%) mortality rate #CircAHA18 #AHA18
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@CircAHA
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27 days
#CircACC24 #SimPub EMPACT-MI analysis: After acute myocardial infarction with left ventricular dysfunction or congestion, empagliflozin reduces the risk of heart failure hospitalizations #AHAJournals @texhern @javedbutler1
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@CircAHA
Circulation
4 years
ISCHEMIA Trial: In patients w/ischemia & CHF (LVEF 35-45%), an early invasive strategy might improve event-free survival #CircESC20 #ESCCongress #AHAJournals @RenatoDLopes1 @DCRINews @DukeHeartCenter @AHAScience
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@CircAHA
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4 years
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@CircAHA
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4 years
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@CircAHA
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6 years
A conceptual framework for addressing residual atherosclerotic cardiovascular disease risk in the era of precision medicine. Learn more:
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@CircAHA
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4 years
Just Published Online: Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Learn more at: #COVID19 #AHACOVID19 #AHAJournals @SebHascoet @AHAScience
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@CircAHA
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4 years
#OnMyMind : A Proposal for Modest Revision of the Definition of Type 1 and Type 2 Myocardial Infarction. #AHAJournals @HighSTEACS
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@CircAHA
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4 years
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@CircAHA
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3 years
#Frontiers : Antithrombotic Therapy in Patients with Atrial Fibrillation Treated with Oral Anticoagulation Undergoing Percutaneous Coronary Intervention: A North American Perspective - 2021 Update #AHAJournals
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@CircAHA
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5 years
Left septal mapping finds that 64% of pts with LBBB on ECG have complete conduction block within prox left system, identifying those most amenable to His corrective pacing. Read more: @DrRoderickTung @gauravaupadhyay
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@CircAHA
Circulation
4 years
Just Published Online: Considerations for choosing the optimal reperfusion strategy for STEMI in the #COVID19 era #AHACOVID19 #AHAJournals @cardiacpolymath @utswheart @AHAScience
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@CircAHA
Circulation
3 years
#CircECG : 73 yo M with recurrent syncope after drinking a Chinese herb liquor. BP 60/40, HR 150. Echo & trop normal. Sinus rhythm restored after K repletion & DCCV. What is the diagnosis? #AHAJournals
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@CircAHA
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6 years
Hand-held echocardiography: current state and future perspectives @WilliamZoghbi #InDepth
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@CircAHA
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4 years
Just Published Online: #Perspective : The hypoxemia and lack of dyspnea in #COVID19 pneumonia is postulated to reflect impaired mitochondrial O2-sensing. Learn more: #AHACOVID19 #AHAJournals @AHAScience @DrStephenArcher
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@CircAHA
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9 months
#OriginalResearch : PCI does not reduce arrhythmic risk (aborted sudden death or sustained ventricular arrhythmias) in patients with stable ischemic LV dysfunction. A subanalysis of @REVIVED_BCIS2 @divaka_perera
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@CircAHA
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2 years
2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
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@CircAHA
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6 years
#InDepth Reappraisal of Ischemic Heart Disease - The fundamental role of coronary microvascular dysfunction in the pathogenesis of angina pectoris @jckaski
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@CircAHA
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4 years
#InDepth : VA- #ECMO for cardiogenic shock: An introduction for the busy clinician @PeterEckmanMD @EBohula @seanvandiepen #AHAJournals
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@CircAHA
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3 years
#OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress testing) was associated with ⬆️ risk of death. Invasive management did not ⬇️ risk in any group. @lesleejshaw #AHAJournals
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@CircAHA
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4 years
#OnMyMind : Severe COVID-19 is a Microvascular Disease: Endothelial exocytosis plays a central role in the pathogenesis of severe #COVID19 . Learn more: #AHACOVID19 #AHAJournals @BrighamWomens @hopkinsheart @AHAScience
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@CircAHA
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4 years
Just Published Online: #InDepthReview : #COVID19 and Cardiovascular Disease. Learn more: #AHAJournals @NYPCUCVI @nyphospital @NirUrielMD
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@CircAHA
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4 years
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@CircAHA
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3 years
A combination of absolute high sensitivity troponin value (<15) and 3h delta (<4) provides a safer mechanism of ruling out #ACS #AHAJournals
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@CircAHA
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4 years
#OnMyMind : Victims of Success in Failure #AHAJournals @lamcardio
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@CircAHA
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3 years
#Review : Myocarditis with COVID-19 mRNA Vaccines ➡️ benefit-risk assessment shows a favorable balance for all age and sex groups @BiykemB @PeterHotez #AHAJournals #COVID19 #AHACOVID19
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@CircAHA
Circulation
3 years
#Review SVG failure is a common complication following #CABG . @esbrilakis et al. explore what is known about the management of this complex field @MHIF_Heart @complexcoronary #AHAJournals
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@CircAHA
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6 months
#JustPublished SimPub #CIRCAHA23 : Left bundle branch area pacing associated w lower incidence of sustained VT/VF & new-onset #AF vs biventricular pacing in patients undergoing CRT: International Collaborative LBBAP Study (I-CLAS)
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@CircAHA
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1 year
#OriginalResearch : In a meta-analysis of 8 studies, 6,000 to 9,000 steps/day was associated with 40% to 50% lower risk of CVD among older adults #AHAJournals
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@CircAHA
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4 years
Just Published Online: #Perspective : Antiplatelet Therapy and #COVID19 @AHAScience #AHACOVID19 #AHAJournals
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@CircAHA
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2 years
#Review What is the relevance of an elevated troponin after exercise? Explore the pathophysiology and clinical significance with @VAengevaeren @ThijsEijsvogels
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@CircAHA
Circulation
3 years
PRADA: Candesartan improves LVEDV and GLS in long-term f/u after anthracycline use for breast cancer , but did not prevent EF decline #CircACC2021 #AHAJournals #ACC21 @AHAScience
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@CircAHA
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6 years
#InDepth : Anemia and iron deficiency in heart failure: current concepts and emerging therapies. Learn more:
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@CircAHA
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3 years
Cardio-oncology - a win-win situation: how solving the mystery of an ibrutinib off-target effect reveals new insights into atrial fibrillation mechanisms #AHAJournals @vgzmd
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@CircAHA
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1 year
#OriginalResearch : Clopidogrel monotherapy was superior to aspirin monotherapy (following 6-18 mo DAPT) in long term follow-up of patients who received coronary stenting #AHAJournals
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@CircAHA
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4 years
#Editorial : Cross-talk between the heart and cancer - Beyond drug toxicity #AHAJournals @CardioOncology
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@CircAHA
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5 years
#WhitePaper : Guiding principles for #CTO #PCI : A global expert consensus document | #AHAJournals @esbrilakis
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@CircAHA
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5 years
#InDepth : Ventricular assist devices have emerged as a durable and safe therapy for end-stage #HF . Here is what you need to know about VADs in the HF paradigm, adverse events, and future directions in engineering and clinical medicine.
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@CircAHA
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3 years
#Editorial : Ticagrelor or Clopidogrel in elderly patients with #MI : When the choice makes the difference #AHAJournals
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@CircAHA
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3 years
#OnMyMind : Avoiding the coming tsunami of common, chronic disease: what the lessons of the #COVID19 pandemic can teach us #AHAJournals #AHACOVID19 @AHAScience @califf001
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@CircAHA
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3 years
#OnMyMind : Gaps in Evidence for Risk Stratification for Sudden Cardiac Death in Hypertrophic Cardiomyopathy #AHAJournals @pelliccia_f
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@CircAHA
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10 months
2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease #AHAJournals
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@CircAHA
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3 years
Just Published: 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease #AHAJournals @AHAScience
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@CircAHA
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3 years
#InDepth Review highlighting current diagnostic and therapeutic approaches to Coronary Artery Anomalies #AHAJournals
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@CircAHA
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4 years
RECEDE-CHF: Empagliflozin in combination with furosemide increased 24-hour urine volume but not urinary sodium in HF patients with T2DM #CircESC20 #ESCCongress #AHAJournals @NatalieMordi @docifymordi @UoDMedicine @AHAScience
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@CircAHA
Circulation
3 years
Immune checkpoint inhibitors are associated with a 3-fold higher risk for atherosclerotic CV events including MI, coronary revascularization and ischemic stroke. Read more here: #AHAJournals @TomasNeilan @zsofidrobni @CIRC_MGH
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@CircAHA
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4 years
Just Published Online: HRS/ACC/AHA Statement on COVID-19 Practice Guidance for Electrophysiologists – risks, impact, and guidance for providers. @DrJCheungEP @rhythmkris @netta_doc #AHACOVID19 #COVID19
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@CircAHA
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3 years
#ECGChallenge : When You Hear Hoofbeats, Look for Horses🐴, Not Zebras🦓! #AHAJournals @drtopaloglu @DursunAras2 @ozcanozeke
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@CircAHA
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3 years
2021 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement From the American Heart Association
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@CircAHA
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2 years
#Editorial : HF?EF: The Mysterious Relationship Between Heart Failure and Ejection Fraction Continues @bborlaugmd @BrenerMickey #AHAJournals
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@CircAHA
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3 years
JUST Published: Key aspects of stat reporting are summarized for authors, reviewers, and readers of AHA journals in Recommendations for Statistical Reporting in CV Medicine. #AHAJournals #Statisticians #Statistics @ADAlthousePhD @EricSecemskyMD
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@CircAHA
Circulation
3 years
#OriginalResearch Simpub #ESCCongress : In this #RCT , influenza vaccination early after an MI or in high-risk CHD resulted in a lower risk of all-cause and CV death #CircESC2021 #AHAJournals
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@CircAHA
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3 years
From PROVE-HF: A substantial proportion of patients with #HFrEF initiated on sacubitril-valsartan have improvement in LVEF to >35% at 6 and 12 months. Important implication for ICD eligibility. #AHAJournals @DukeHFDoc @DCRINews @JJheart_doc @RxPDX
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@CircAHA
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7 months
Oral anticoagulation use after Left Atrial Appendage Occlusion (LAAOS III): LAA occlusion provides protection against ischemic stroke and systemic embolism independent of the use of OAC therapy. @RichardWhitloc2 #LAAOSIII
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@CircAHA
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4 years
Just Published Online: #Perspective : Given immune system over-activation & microvascular thrombosis in severe #COVID19 , could the complement cascade be a new target for therapy? #AHACOVID19 #AHAJournals @CampbellMDPhD @OSUWexMed @AHAScience
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@CircAHA
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3 years
Empagliflozin caused a significant increase in 24-hour urine volume without an increase in urinary sodium when used in combination with loop diuretic #RecedeCHF #AHAJournals @NatalieMordi @docifymordi @UoDMedicine
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@CircAHA
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4 years
First-In-Human Experience with Inhaled Acetylsalicylic Acid for Immediate Platelet Inhibition: Comparison with Chewed & Swallowed Acetylsalicylic Acid #AHAJournals @PGurbel @LBHealth
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@CircAHA
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1 year
#OriginalResearch simpub #AHA2022 : In this #RCT immediate implementation of VA-ECMO in patients with cardiogenic shock did not improve clinical outcomes compared with an early conservative strategy which allowed downstream use of... #CIRCAHA22 #AHAJournals
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@CircAHA
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7 years
International expert consensus on switching P2Y12 inhibitors|recommendations for individual optimization #CIRCTCT17
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@CircAHA
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6 years
On My Mind: Framework for Addressing Residual #ASCVD Risk. Learn more at
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@CircAHA
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1 year
#OriginalResearch : In HFpEF, acutely lowering PCWP during exercise with nitro did not improve VO2 suggesting elevated PCWP during exercise not the primary cause of limits in exercise capacity #AHAJournals
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@CircAHA
Circulation
2 years
#ResearchLetter Simpub #HeartFailure2022 : Combination Rx (ARNI+MRA+SGLT2i) estimated to have substantial benefits in averting clinical events across broad range of LVEF up to 60-65% @mvaduganathan @gcfmd @UoGHeartFailure @scottdsolomon #AHAJournals
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@CircAHA
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1 year
#OriginalResearch : Left atrial appendage occlusion was associated with a lower risk of death, stroke and bleeding compared to anticoagulation among females and males @EmilyZeitler @JonHsuMD @AndreaRussoEP @drdevignair @djdardenMD @MCoylewright
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@CircAHA
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4 years
#Empagliflozin in Heart Failure: Diuretic & Cardio-Renal Effects. Empagliflozin causes significant natriuresis, particularly when combined w/ loop diuretics, resulting in an improvement in blood volume. Learn more: #AHAJournals @DanielJacobyMD @yaleHFdoc
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@CircAHA
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5 years
Just Published in Circulation: 2018 Guideline on the Management of Blood Cholesterol #AHA18
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@CircAHA
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3 years
Mitochondrial dysfunction in vascular smooth muscle cells promotes aortic dilation & aneurysms in #Marfan Syndrome; potential new therapeutic strategy for mananging genetic aortic aneurysms #AHAJournals @MMittelbrunn @JorgeOller4 @UAM_Madrid @UAI_imas12
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@CircAHA
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5 years
#WhitePaper : Myocarditis in the setting of cancer therapeutics: Proposed case definitions for emerging clinical syndromes in #CardioOnc | #AHAJournals @MarcBonaca @CardioOncology
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@CircAHA
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3 years
EXPLORER-HCM CMR substudy finds that mavacamten favorably impacts cardiac structure in obstructive HCM. Read more: #AHAJournals @S2beri
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@CircAHA
Circulation
3 months
The randomized controlled trial Frail Atrial Fibrillation ( #FRAIL -AF) showed that switching from vitamin K antagonists #VKA to non-vitamin K oral anticoagulant #NOAC in frail older patients with AF was associated with more bleeding complications
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@CircAHA
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3 years
An international, multicenter cohort study finds LV unloading was associated with lower mortality in cardiogenic shock patients treated with VA-ECMO, despite higher complication rates #AHAJournals @SunnyVMD @thiele_holger
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@CircAHA
Circulation
4 years
A 77 yo man with h/o T2DM, HTN and pAF on Metoprolol and Flecainide p/w palpitations. He is given an additional 200 mg of Flecainide for 2:1 A flutter. What is the rhythm and how should it be treated? @JeffWagnerMDMCR #AHAJournals
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@CircAHA
Circulation
5 years
Multi-center study first to show that acute #takotsubo cardiomyopathy is characterized by myocardial & systemic inflammation, followed by a low-grade chronic inflammatory state. Read more:
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@CircAHA
Circulation
3 years
In 10-yr follow-up of STICH trial, inducible myocardial ischemia on stress testing not associated with worse long term survival in patients with ischemic cardiomyopathy. Read more: @DavidLBrownMD @WUSTLmed @WUSTL #AHAJournals
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@CircAHA
Circulation
2 years
#OriginalResearch SimPub #AHA21 : The #AVATAR RCT of 157 patients with asymptomatic severe #AS and normal LVEF found that early #SAVR associated w/reduced composite outcome of death, MI, stroke or HF hospitalization compared to mgmt. #AHAJournals
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@CircAHA
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4 years
Effectiveness of deep sedation for patients with intractable electrical storm refractory to anti-arrhythmic drugs #AHAJournals @MartinsRaphae15 @EloiMarijon
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@CircAHA
Circulation
4 years
Just Published Online: #OnMyMind Angiotensin-(1-7) may be useful to protect the lungs of high risk patients infected with SARS-CoV-2 responsible for the Covid-19 pandemic. #COVID19 #AHACOVID19 @AHAScience
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@CircAHA
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4 years
#WhitePaper : Searching for #AtrialFibrillation Post-Stroke: A White Paper of the AF-SCREEN International Collaboration. Learn more: #AHAJournals @DrTerryQuinn
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@CircAHA
Circulation
2 years
#InDepth #E -cigarettes are increasing in popularity. Explore an in-depth review on potential harms and current use. @woldloren #AHAJournals
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@CircAHA
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6 years
#WhitePaper : Antithrombotic therapy in pts with #AFib treated with oral anticoagulation undergoing #PCI : A North American perspective.
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@CircAHA
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4 years
#OnMyMind : The Universal Definition of #Myocardial #Infarction - Present and Future. Learn more: #AHAJournals
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@CircAHA
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3 years
#InDepth : Cardiovascular disease in chronic kidney disease: pathophysiological insights and therapeutic options #AHAJournals
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@CircAHA
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4 years
#InDepth : Systemic consequences of pulmonary hypertension & right-sided heart failure #AHAJournals
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@CircAHA
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6 years
#Primer : Sex differences in #CV pathophysiology: Why women are overrepresented in #HFpEF @drabeale
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@CircAHA
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3 years
#Editorials : SGLT2 inhibitors in patients with HFrEF: The heart and kidney working better together. Learn more: #AHAJournals @robmentz
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@CircAHA
Circulation
11 months
#StateOfTheArt : Subepicardial cardiomyopathy - a disease underlying J-wave syndromes and idiopathic ventricular fibrillation @BehrElijah @Chiara_Scrocco @bjboukens @DrCJMiles #AHAJournals
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