ASCI
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Founded in 1908, the ASCI is home to 3,000+ physician-scientists active across academic medicine and industry.
Ann Arbor, MI
Joined June 2017
Kicking off the 2025-2026 ASCI Scientific Sessions: Funda Meric-Bernstam, MD @MDAndersonNews "Optimizing therapy with antibody drug conjugates" Sept. 17, 1-2pm ET Moderator: Rajan Jain, MD @PennMedicine Free & open to all. Register: https://t.co/9kM3supqJg
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Understanding the STING in autoimmunity! ASCI member Anthony Shum & team @UCSF investigate mouse models of the immune dysregulation disorder COPA syndrome and show STING activation in thymic epithelial cells has a role in shaping the T cell repertoire and promoting autoimmunity:
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In ALS, TDP43 mislocalizes to the cytoplasm, but the factors contributing to its exclusion were a mystery. Sami J. Barmada (YPSA) & team @UMichMedSchool now introduce a mechanism for nucleocytoplasmic transport defects in TDP43 proteinopathies, providing a framework for
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Welsh, González, and Negulescu share #LaskerAward @LaskerFDN recognizing transformative treatments for people with cystic fibrosis ASCI members Benjamin D. Singer & G.R. Scott Budinger @NUFeinbergMed provide a historical context for this year’s Lasker~DeBakey Award on the
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The A20 protein is linked to Crohn’s disease and celiac disease, but the link to IL-22-driven enteritis was unknown. ASCI member Averil Ma & team @UCSF now describe spontaneous proximate enteritis in A20-knockin mice, revealing a binding motif that restrains IL-22 regulation in
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Beyond repair for cancer cells! Using a mantle cell lymphoma model, ASCI member Alan D'Andrea & team @danafarber find cyclin D1 overexpression induces replication stress and DNA damage, forcing cells to rely on repair pathways that can be targeted for therapy.
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Industrial smog events, such as the 1952 London smog, spurred widespread concern over pollutant toxicities. In this Review, Robert B. Hamanaka & ASCI member Gokhan M. Mutlu @UChicago provide an overview for the mechanisms by which particulate matter leads to adverse health
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Can we bring microbiome-based interventions into clinical use? As part of JCI’s Review series on #Microbiome in Health and Disease, Megan S. Kennedy & ASCI member Eugene B. Chang @MicrobiomeDoc @UChicago discuss emerging concepts and shifting paradigms for understanding the
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Combating intracellular mycobacterial infections! This issue’s cover features work by ASCI member Robert L. Modlin & team @dgsomucla on an antimicrobial gene signature associated with reduced Mycobacterium leprae burden: https://t.co/YqQZztNju1 The image shows a colorized
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What is the role of inhaled DNA (and nucleosomes) in asthma? ASCI member Rafeul Alam & team @NJHealth establish a paradigm whereby allergens inhibit the anti-inflammatory effects of DNA/Nuc and facilitate STING/TNF-α–driven neutrophilic-eosinophilic inflammation in asthma.
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Chronic diseases alter the platelet rheostat to promote hyperreactivity and thrombosis: https://t.co/W8i2UB9tJl ASCI member @RSilversteinMD @MedicalCollege provides a Commentary on Kong et al. ( https://t.co/98141ITFZs)
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Another brick in the aortic wall ASCI member Y. Eugene Chen & team @UMichMedSchool profile the spatial transcriptomic landscape in unaffected and aneurysmal aortic tissues from mouse models. See complete report: https://t.co/t7Yzqcm8uW
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What’s the frequency? In this research letter, ASCI member @ldiaz1971 & team @MSKCancerCenter use clonal hematopoiesis as a model for simultaneous assessment of somatic mutations across multiple biosamples. https://t.co/k2NTBpLw2p
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ASCI Early-Career Award Nominations are open: Emerging-Generation + Young Physician-Scientist Awards High-level recognition on this critical career path! Awardees access @JointMeeting, networking, and career-development opportunities. Deadline: Oct. 15 More at:
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Epstein-Barr virus is a major cause of lymphoproliferative disease, but patients with XLP-2 mutations are protected from the development of lymphoma. ASCI member @BenGewurz & team @BrighamsWomens discover XIAP mutation impedes EBV-driven B-cell transformation and lymphomagenesis
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ASCI Early-Career Award Nominations are open: Emerging-Generation + Young Physician-Scientist Awards High-level recognition on this critical career path! Awardees access @JointMeeting, networking, and career-development opportunities. Deadline: Oct. 15 More at:
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It has long been believed that skin and hair follicles are maintained by compartmentalized stem cells. This issue’s cover features work by ASCI member Lu Q. Le @LuLe_MD_PhD & team @UVA, @MedicineUVA on the contribution of hair follicle epithelial stem cells to interfollicular
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Behind the Scenes with principal contributors from the Mani and Castrillon labs at UT Southwestern. Left to right, Ram Mani, Diego H. Castrillon, Susmita Ramanand, and Subhransu Sahoo.
The incidence of endometrial cancer continues to rise each year. ASCI member Diego Castrillon & team @UTSWMedCenter establish a new mechanism of tumor-suppressor inactivation in which epigenetic reprogramming silences PAX2 and initiates endometrial carcinogenesis:
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The incidence of endometrial cancer continues to rise each year. ASCI member Diego Castrillon & team @UTSWMedCenter establish a new mechanism of tumor-suppressor inactivation in which epigenetic reprogramming silences PAX2 and initiates endometrial carcinogenesis:
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