Children infected with the
#COVID19
outbreak coronavirus, SARS-CoV-2, show mild symptoms but prolonged shedding of viral RNA in feces, suggesting that the fecal–oral route might play a role in virus transmission
#CORONAVIRUS
A longitudinal analysis of humoral immune responses in patients with
#COVID19
with varying disease severity reveals that mortality does not correlate with antiviral antibody levels but, instead, with slower seroconversion.
#immunology
@VirusesImmunity
Humanitarian aid must be allowed to enter the besieged Tigray region of Ethiopia.
Correspondence from Wasan M. Kumar, Bereket A. Gebregziabher, Reiye E. Mengesha and Paul Wise
@Stanford
A single-cell analysis of tumor-infiltrating T cells from 16 cancer types identifies new T cell subsets and a stress response cell state enriched in tumors resistant to immunotherapy.
Surge in endometriosis research after decades of underfunding could herald new era for women’s health.
News feature by
@clarewhatson
, as part of our Series on Women's Health
To celebrate
#BlackHistoryMonth
, we're highlighting pieces by and about fantastic Black researchers in the United States. First up:
@FutureDrDukes
, the founder of
@BlackInNeuro
, shares ways you can better support Black trainees in the biomedical sciences
The muscle-secreted, exercise-induced peptide hormone apelin decreases with
#aging
and sarcopenia, and its repletion in aged mice with recombinant protein improves muscle mass and function:
Nature Medicine summarizes all the research you need to know this week on the
#COVID19
pandemic. This week, read about the convalescent plasma transfusion study showing promise for treating critically ill patients with
#coronavirus
disease 2019
Despite elevated brain
#amyloid
pathology, a unique human case harboring a rare mutation in
#APOE
is reported by
@ytquiroz
and colleagues to be resistant to inherited
#Alzheimer
’s disease |
Humanitarian aid must be allowed to enter the besieged Tigray region of Ethiopia.
Correspondence from Wasan M. Kumar, Bereket A. Gebregziabher, Reiye E. Mengesha and Paul Wise
@Stanford
Initial results from a first-in-human study show that PET imaging with PD-L1 antibodies outperforms immunohistochemistry- or RNA-sequencing-based biomarkers for prediction of clinical response to
#immunotherapy
:
A single-cell analysis of tumor-infiltrating T cells from 16 cancer types identifies new T cell subsets and a stress response cell state enriched in tumors resistant to immunotherapy.
Analyses of 1,277 human brain proteomes reveal the extent of sex differences in the brain and identify genes associated with neuropsychiatric diseases that have differential regulation between males and females
@wingolab
@EmoryMedicine
Humanitarian aid must be allowed to enter the besieged Tigray region of Ethiopia.
Correspondence from Wasan M. Kumar, Bereket A. Gebregziabher, Reiye E. Mengesha and Paul Wise
@Stanford
A single-cell spatial transcriptomic and proteomic study of
#immune
cells in the human
#CNS
border compartments reveals differences in CNS-associated macrophages across age, perturbation and disease.
@r_sankowski
#macrophages
#microglia
Nature Medicine summarizes all the research you need to know this week to keep on top of how science is responding to the
#COVID19
pandemic.
#coronavirus
11 trailblazing early-career researchers, shaping the future of
#medicine
, share what they are most excited about right now and where their research is going in the next 5 years - read now:
Results from a phase 3 randomized clinical trial demonstrate that MDMA-assisted therapy is safe and effective for treating patients with severe post-traumatic stress disorder.
#PTSD
@UCSF
In recovered
#COVID19
patients, virus spike-specific
#antibodies
were consistently elicited, but neutralizing activity was variable and inversely correlated with the proportion of CCR6+CXCR3- spike-specific circulating T follicular helper cells.
@unimelb
11 clinical trials that will shape medicine in 2024 - from base editing and a vaccine against HIV to AI tools for lung cancer and patient triage.
Part of our Year in Review, by Paul Webster and
@edbites
SARS-CoV-2 is not unique in its ability to cause long-term sequelae.
In our latest Review: Akiko Iwasaki, Jan Choutka & colleagues discuss what we know (& don't know) about unexplained post-acute infection syndromes
@jan_choutka
@VirusesImmunity
@YaleMed
A single-cell spatial transcriptomic and proteomic study of
#immune
cells in the human
#CNS
border compartments reveals differences in CNS-associated macrophages across age, perturbation and disease.
@r_sankowski
#macrophages
#microglia
A cross-sectional study of hospitalized patients with
#COVID19
and a longitudinal follow-up study of patients with
#COVID_19
suggest that
#SARS_COV_2
-specific IgG or IgM seroconversion occurs within 20 days post symptom onset.
#AntibodyTesting
#Antibody
.
Boosting
#CARTcells
with anti-tumor
#mRNAvaccines
led to robust anti-neoplastic activity in patients with genitourinary cancers, paving the way for a promising new treatment strategy.
News and Views from
@montypal
& colleagues
@cityofhope
#ESMO2023
Out today for
#ESMO23
: In a large multi-cancer cohort, a single liquid biopsy assay enables the detection of four epigenomic modifications, allowing the monitoring of expression of potential drug targets and resistance genes
@SylvanBacaLab
@DrChoueiri
Today, together with
@NEJM_AI
, we present a statement from the RAISE Consortium mapping immediate actions for healthcare leaders to support the responsible and ethical transition of healthcare to an AI-powered future. Read it now:
@HarvardDBMI
@zakkohane
First-generation students, whose parents do not have degrees, are under-represented on MD-PhD programmes and need better support, argue
@BriChristophers
and colleagues at
@TriIMDPhD
#firstgen
An mRNA
#vaccine
platform to prevent HIV-1 infection generated broadly neutralizing antibodies in nonhuman primates and protected some animals from infection, raising hope that optimization of this approach might lead to an effective
#HIV
vaccine
@NIAIDNews
Rotten eggs get their awful stink from hydrogen sulfide. But there might be an upside to this gas: in a new mouse study, it prevented clogged arteries:
Nature Medicine summarizes all the research you need to know this week on the
#COVID19
pandemic. This week, read about the epidemiological analysis of 72 hospitals in Lombardy, Italy, where the ICU mortality rates were 26%. Free now, online.
#Coronavirus
A large, publicly available dataset integrating RNA, whole-exome, T cell receptor and 16S rRNA sequencing from patients with
#ColonCancer
enables the discovery of a
#PrognosticScore
consisting of tumor, immune and microbial features.
#Microbiome
#Tcell
A cohort of asymptomatic patients infected with
#SARSCoV2
had significantly lower levels of virus-specific IgG antibodies compared to a cohort of age- and sex-matched symptomatic infected patients.
#COVID19
#asymptomatic
#coronavirus
#CQMU
A cross-sectional study of hospitalized patients with
#COVID19
and a longitudinal follow-up study of patients with
#COVID_19
suggest that
#SARS_COV_2
-specific IgG or IgM seroconversion occurs within 20 days post symptom onset.
#AntibodyTesting
#Antibody
.
Nature Medicine is turning 25 this year! To kick off our 25th year, we've put together a focus issue on Digital Medicine. Check out the table of contents here:
Hi, I'm Joao Monteiro, chief editor
@NatureMedicine
and I'll be taking over the journal's account this week - follow me using the hashtag
#NMEDtwittertakeover
A
#single
-cell atlas of the human
#lungs
, integrating data from 2.4 million cells from 486 individuals and including samples from healthy and diseased lungs, provides a roadmap for generating organ-scale cell atlases.
@SikkemaLisa
@MDLuecken
@fabian_theis
⭐Research highlight: Patients who received an in vivo
#CRISPR
based gene-editing therapy for hereditary angioedema showed no serious side effects and nearly complete disease control.
@NEJM
11 clinical trials that will shape medicine in 2024 - from base editing and a vaccine against HIV to AI tools for lung cancer and patient triage.
Part of our Year in Review, by Paul Webster and
@edbites
The search for authentic microbiome–disease relationships.
A new study challenges the validity of previously reported microbial markers and serves as a wake-up call for the
#microbiome
research field. News and Views from
@zhu_ruixin
& colleagues
A risk score developed using biological, psychological, and social factor data from the
@uk_biobank
can predict different pain conditions and the prognosis of chronic pain up to 9-years later
@evp82
@TanguaySabourin
Implantation of a multielectrode paddle that allows personalized electrical stimulation to all regions of the spinal cord involved in leg and trunk movements rapidly restores motor function in spinal cord injury patients with complete paralysis
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe
#COVID19
and the presence of clonally expanded CD8+ T cells in those with moderate COVID-19.
Developed using diverse sources of histopathology images, biomedical text and over 1.17 million image-caption pairs, a visual-language foundation model achieves state-of-the-art performance on a wide array of clinically relevant pathology tasks.
Prof. Akiko Iwasaki from
@YaleMed
discusses the pervasive problem of principal investigators who abuse their powers and mistreat their trainees. International trainees are particularly vulnerable, as PIs can hold them hostage with their visas.
#academia
A genome-wide meta-analysis of data from 6 US and European cohorts involving 1.3 million individuals identifies 243 genetic variants associated with risk and pathophysiology of depression
@AndersBorglum
The human heart contains 2 types of macrophages with distinct self-maintenance & inflammatory functions. An imbalance between these macrophage types correlates with left-ventricle remodeling & systolic function in patients w/heart failure:
#WorldHeartDay
The human heart contains 2 types of macrophages with distinct self-maintenance & inflammatory functions. A shift in the balance between these macrophage populations correlates with left-ventricle remodeling & systolic function in patients w/heart failure:
Understanding the dynamics of the gut
#Microbiota
over the course of
#Cancer
treatment regimens and their associated adverse events can help identify microbial features that associate with response to immune checkpoint blockade.
A new epidemiological study shows reduced susceptibility to
#SARSCoV2
and decreased risk of developing severe symptoms in people aged younger than 20 years, suggesting that children have limited contribution to spread of
#COVID19
.
@LSHTM
@cmmid_lshtm
During the COVID-19 pandemic, the public have turned to scientists and doctors for vital information. But science communication is a skill in itself, so we asked the experts to share their tips.
Feature from
@polkajunction
Gemcitabine + cisplatin + anti-PD-1 led to complete response in 43% of patients with muscle-invasive
#BladderCancer
, which facilitated bladder sparing and was associated with long-term bladder-intact survival.
@MattGalsky
@TischCancer
@IcahnMountSinai
Pretrained using over 100,000 diagnostic histopathological slides across 20 major tissue types, a self-supervised model is shown to outperform existing baselines across various clinically relevant tasks
@AI4Pathology
@harvardmed
EDITORIAL - Government officials who disseminate unsupported claims about the novel coronavirus undermine public trust in science and in the public-health efforts that are essential to bringing the
#COVID19
pandemic under control >
The gut
#microbiome
of Irish Travellers, an ethnically distinct sub-population of Ireland, are similar to microbiomes of non-industrialized populations, but externally-imposed
#lifestyle
changes may alter their microbiota, with potential
#health
sequelae
After anti-PD-1 therapy in basal or squamous cell carcinoma patients, the CD8+ T cell response largely consists of an expanded and exhausted repertoire of new
#Tcell
clones |
#ImmunoTherapy
@HowardYChang
Human sera from recipients of the BNT162b2 Pfizer-BioNTech vaccine can neutralize SARS-CoV-2 viruses containing spike mutations present in globally circulating variants of concern
@utmbhealth
#COVID19
#vaccines