Randy Perera
@Randy_PereraX
Followers
93
Following
562
Media
5
Statuses
131
Experienced Scientist | Protein Purification | Biophysics | Structural Biology | Published Researcher | World History | Books | Movies | TV | Sports | Astrophil
Joined November 2009
StarCraft 2 Warcraft 3 Command & Conquer Red Alert Age of Empires 2 If you think about it, we were truly spoiled. What a time to be a gamer then, witnessing absolute milestones of gaming history. There was a time when RTS games ruled the gaming world. And while that time might
332
380
4K
This is a nice Quanta article on mechanical forces in biology. The flow of wine down the sides of a glass (called the Marangoni flow) "is similar to the flow of the tissue in the gastruloid" of a developing embryo. A cell is a vibrating bag of molecules, but those molecules can
10
36
304
A hard decision that every proteinologist must make
12
26
270
The possibilities for AI-powered protein design are endless! In this case study we show how we used BindCraft to engineer a programmable maltose biosensor from scratch, including wet lab validation at Adaptyv of course. We envision a future where every biologist can make their
7
39
156
In a single E. coli, about 25 percent of all proteins use metals (like zinc, iron, copper, magnesium, etc) to do their chemistries. And yet, incredibly, fewer than ONE FREE METAL ION is present per cell on average. There are, in other words, basically no loose metal ions
23
199
1K
Architecture of the photosynthetic oxygen evolving center in dark-adapted photosystem II Find out more at https://t.co/osrz3c9TtG
0
2
12
๐ ๐ซ๐๐ฆ๐ข๐ง๐๐๐ซ ๐ญ๐ก๐๐ญ ๐ฉ๐ซ๐จ๐ญ๐๐ข๐ง๐ฌ ๐๐ซ๐ ๐ก๐ข๐ ๐ก๐ฅ๐ฒ ๐๐ฒ๐ง๐๐ฆ๐ข๐ ๐ฆ๐จ๐ฅ๐๐๐ฎ๐ฅ๐๐ฌ. Static protein structures are useful, as long as we remember that they capture only one conformation of a protein. 1/2
5
44
219
New story - the structure of the Vault cap at 2.3 ร
! Fantastic work by Huan Li (@huanli00). For more details, read the preprint, or check out my thread at the other place! ๐๐ฆโ๏ธ https://t.co/8rWD6FRP5q
8
32
181
Think coronavirus spikes have run out of surprises? Think again. Our latest preprint dives into the highly unusual spikes of marine mammal coronaviruses. https://t.co/DE0rFm2W4g This #cryoEM study was led by @rubenhulswit, with key contributions from an amazing team.
2
9
46
Now an AI (GelGenie) can analyze our ugly electrophoresis bands. Are you feeling the AGI? ๐ฆ GelGenie: an AI-powered framework for gel electrophoresis image analysis https://t.co/8sqXh0pysd
Very cool newly published open-source software for ML-based Gel image analysis: https://t.co/RCgEA8mxdN And great paper too: https://t.co/p3LtPKPjCm
0
4
9
I am hiring a postdoc in AI-development for protein binder design for my lab at Stockholms universitet and SciLifeLab. The environment is fantastic with many opportunities for collaboration and development of independent research directions. Apply here: https://t.co/nNaOmosoqV
4
23
120
This is jaw dropping level stuff!
Excited to share our pre-print on the molecular architecture of heterochromatin in human cells๐งฌ๐ฌ w/ @jpkreysing, Johannes Betz,Turoลovรก lab, @MarinaLusic, Hummer lab, @Beck_Laboratory, @MPIbp ๐ Preprint here: https://t.co/0tTxZcu0Vz
1
15
78
Beautiful animation of metabolic flux in the mitochondrial Kreb (TCA) cycle The three "CO2" coming off the cycle is how you lose weight: carbon from your material body coming off as gas you end up breathing out By @janetiwasa
58
997
4K
The @BriggsGroup, alongside teams from @CiidHeidelberg and @YaleMicroPath, uncover the elusive role of the #HIV-1 component SP2. Detailed 3D views of virus particles by #cryoEM show how SP2 helps the virus matrix to mature. โRead the paper @Nature: https://t.co/FpcH2VCTa8
1
21
61
What's better than 1 deep mutational scanning (DMS) library? 2! In a new pre-print @BW_Thornton and @rachelfweissman et al. map the mutational landscape of ISDra2 TnpB protein and reRNA and leverage these datasets to engineer highly active variants (1/9)
4
60
217
Synthetic evolution of Saccharomyces cerevisiae for biomanufacturing: Approaches and applications https://t.co/Uxmryla2QU
1
15
76
Jupiter and Mars dance around the sun, creating an amazing pattern.
32
386
2K
I was happy to write a @Nature News and Views on the amazing discoveries by @brian_b_liau & Ning Zheng lab on how a molecular glue unexpectedly mimics the effect of cancer mutations. Such cool science and with implications to drug discovery. @NatureNV
3
34
170
Congrats Simon! I enjoyed our time together while starting protein design at DeepMind. Excited to see what you build. Consider joining latent labs if you're interested in ML and bio!
@Latent_Labs comes out of stealth today with $50M funding. Our goal? To push the frontiers of generative biology, giving partners instant access to tools capable of accelerating drug design. Every biotech or pharma company searching for the best therapeutic molecules understands
0
3
63
The gut-brain axis has therapeutic implications for neurodegenerative disorders. ๐งต1/9
21
262
1K