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Beck Laboratory Profile
Beck Laboratory

@Beck_Laboratory

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#MolecularSociology @MPIbp @becklab.bsky.social

MPI of Biophysics, Frankfurt
Joined August 2017
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@Beck_Laboratory
Beck Laboratory
5 months
RT @mpgpresident: Künftig könnten sich mehr Forschende aus den USA bei uns bewerben – doch der Grund ist besorgniserregend. #Forschung gerä….
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@Beck_Laboratory
Beck Laboratory
6 months
Dear All,.Please find us at Bluesky. @becklab.bsky.social.Martin.
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@Beck_Laboratory
Beck Laboratory
6 months
We propose that the dilation state of #nuclearpores modulates its permeability and consequently fluid flow, which is important in response to osmotic stress or when cells squeeze through constrictions. Great collaborative effort by @pc_hoffmann @aobarska Henry Kim and @HummerLab.
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@Beck_Laboratory
Beck Laboratory
6 months
Difference between diffusion and flow? If you drip paint into a river it locally dissolves by diffusion. It goes downstream driven by flow. We quantify flow through #nuclearpores in response to rapid nuclear size changes. @MPIbp #TEAMTOMO @MolecularCell .
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@Beck_Laboratory
Beck Laboratory
7 months
RT @Nature: Nature research paper: In situ analysis reveals the TRiC duty cycle and PDCD5 as an open-state cofactor
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@Beck_Laboratory
Beck Laboratory
7 months
… and perfect timing. Work by @HuaipengXing with @FrydmanLab out @Nature. PDCD5 binds virtually all open #TRiC, while closed TRiC forms clusters inside of cells. Congrats to all authors.
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@Beck_Laboratory
Beck Laboratory
7 months
Congrats to @HuaipengXing for defending his PhD. First PhD hat @goetheuni 😎
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@Beck_Laboratory
Beck Laboratory
7 months
Emotional leaving event for @Reiya_Tan1guch1 who is departing @MPIbp towards @riken_en. Best of Luck Reiya!
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@Beck_Laboratory
Beck Laboratory
6 years
Many congratulations to Reiya Taniguchi @018_xviii , for securing the @EMBO long-term fellowship.
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@Beck_Laboratory
Beck Laboratory
7 months
RT @HeilemannLab: We modified our STED🔬to make it more efficient ('smart') to acquire high-resolution data of small and rare objects in a 3….
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@Beck_Laboratory
Beck Laboratory
9 months
@JennySachweh Now online as a preprint Thanks to the whole team for the productive collaboration! @MandyBoermel, @svenklumpe, @Reiya_Tan1guch1, @MartaKubanska, @WilflingFlorian.
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@Beck_Laboratory
Beck Laboratory
9 months
@JennySachweh Compartment-specific chaperoning and transport of peripheral Nups through the nuclear transport system control both the (a)symmtery of NPCs and explains how the cell can convert NPC precursors into functional NPCs upon relocation into the NE.
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@Beck_Laboratory
Beck Laboratory
9 months
@JennySachweh Thus, (a)symmetry of NPCs is not determined by the structure of their core. Instead, the nucleotide state of the small GTPase Ran, a key component of the nuclear transport system, alters the binding of peripheral components in the nuclear and cytoplasmic environment.
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@Beck_Laboratory
Beck Laboratory
9 months
@JennySachweh Nuclear envelope NPCs carry two different peripheral substructures on the nuclear and cytoplasmic side. Cytoplasmic NPCs carry two cytoplasmic rings, nucleoplasmic NPCs two nuclear rings. However, all comprise a core scaffold that is symmetric across the membrane plane.
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@Beck_Laboratory
Beck Laboratory
9 months
@JennySachweh Nucleoplasmic NPCs exist in extensions of the inner nuclear membrane, and cytoplasmic NPCs in ER sheets can help the nuclear envelope grow! Using in situ cryoET, we find that such ectopic NPCs are symmetric across the membrane plane - in contrast to NPCs on the nuclear envelope.
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@Beck_Laboratory
Beck Laboratory
9 months
Did you know that nuclear pore complexes can turn up outside the nuclear envelope? Studying these, @JennySachweh, Bernhard Hampoelz and others uncover that the surrounding cellular milieu determines NPC composition via the nuclear transport system itself. #teamtomo #NPC A 🧵
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@Beck_Laboratory
Beck Laboratory
11 months
RT @EMBLEvents: 🙋🏻🔬 #EMBOinsitu is open for registrations!. From cryo-EM to multi-scale modelling - what types of biological questions can….
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@Beck_Laboratory
Beck Laboratory
1 year
RT @maxplanckpress: Ready to lead your own research team-?😎The Max Planck Society offers you the chance to head an independent Research Gro….
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@Beck_Laboratory
Beck Laboratory
1 year
RT @mpi_nat: #PhD, #DnD(?) & #postdoc positions in “theory and methods for non-equilibrium atomistic simulations of complex #biomolecules”….
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@Beck_Laboratory
Beck Laboratory
1 year
RT @Herrmann_lab: We recently discovered a priority code in presequences of mitochondrial precursors. Some are much ‚stronger‘ than others….
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@Beck_Laboratory
Beck Laboratory
1 year
RT @labs_mann: Incredibly proud of Matthias Mann for winning this year's Dr. H.P. Heineken Prize for Biochemistry and Biophysics together w….
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