
Beck Laboratory
@Beck_Laboratory
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#MolecularSociology @MPIbp @becklab.bsky.social
MPI of Biophysics, Frankfurt
Joined August 2017
RT @mpgpresident: Künftig könnten sich mehr Forschende aus den USA bei uns bewerben – doch der Grund ist besorgniserregend. #Forschung gerä….
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We propose that the dilation state of #nuclearpores modulates its permeability and consequently fluid flow, which is important in response to osmotic stress or when cells squeeze through constrictions. Great collaborative effort by @pc_hoffmann @aobarska Henry Kim and @HummerLab.
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Difference between diffusion and flow? If you drip paint into a river it locally dissolves by diffusion. It goes downstream driven by flow. We quantify flow through #nuclearpores in response to rapid nuclear size changes. @MPIbp #TEAMTOMO @MolecularCell .
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RT @Nature: Nature research paper: In situ analysis reveals the TRiC duty cycle and PDCD5 as an open-state cofactor
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… and perfect timing. Work by @HuaipengXing with @FrydmanLab out @Nature. PDCD5 binds virtually all open #TRiC, while closed TRiC forms clusters inside of cells. Congrats to all authors.
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Emotional leaving event for @Reiya_Tan1guch1 who is departing @MPIbp towards @riken_en. Best of Luck Reiya!
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RT @HeilemannLab: We modified our STED🔬to make it more efficient ('smart') to acquire high-resolution data of small and rare objects in a 3….
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@JennySachweh Now online as a preprint Thanks to the whole team for the productive collaboration! @MandyBoermel, @svenklumpe, @Reiya_Tan1guch1, @MartaKubanska, @WilflingFlorian.
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@JennySachweh Compartment-specific chaperoning and transport of peripheral Nups through the nuclear transport system control both the (a)symmtery of NPCs and explains how the cell can convert NPC precursors into functional NPCs upon relocation into the NE.
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@JennySachweh Thus, (a)symmetry of NPCs is not determined by the structure of their core. Instead, the nucleotide state of the small GTPase Ran, a key component of the nuclear transport system, alters the binding of peripheral components in the nuclear and cytoplasmic environment.
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@JennySachweh Nuclear envelope NPCs carry two different peripheral substructures on the nuclear and cytoplasmic side. Cytoplasmic NPCs carry two cytoplasmic rings, nucleoplasmic NPCs two nuclear rings. However, all comprise a core scaffold that is symmetric across the membrane plane.
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@JennySachweh Nucleoplasmic NPCs exist in extensions of the inner nuclear membrane, and cytoplasmic NPCs in ER sheets can help the nuclear envelope grow! Using in situ cryoET, we find that such ectopic NPCs are symmetric across the membrane plane - in contrast to NPCs on the nuclear envelope.
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Did you know that nuclear pore complexes can turn up outside the nuclear envelope? Studying these, @JennySachweh, Bernhard Hampoelz and others uncover that the surrounding cellular milieu determines NPC composition via the nuclear transport system itself. #teamtomo #NPC A 🧵
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RT @EMBLEvents: 🙋🏻🔬 #EMBOinsitu is open for registrations!. From cryo-EM to multi-scale modelling - what types of biological questions can….
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RT @maxplanckpress: Ready to lead your own research team-?😎The Max Planck Society offers you the chance to head an independent Research Gro….
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RT @mpi_nat: #PhD, #DnD(?) & #postdoc positions in “theory and methods for non-equilibrium atomistic simulations of complex #biomolecules”….
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RT @Herrmann_lab: We recently discovered a priority code in presequences of mitochondrial precursors. Some are much ‚stronger‘ than others….
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RT @labs_mann: Incredibly proud of Matthias Mann for winning this year's Dr. H.P. Heineken Prize for Biochemistry and Biophysics together w….
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