Künftig könnten sich mehr Forschende aus den USA bei uns bewerben – doch der Grund ist besorgniserregend. #Forschung gerät unter politischen Druck . #Wissenschaft braucht Freiheit & #Evidenz. Mehr dazu:

Dear All, Please find us at Bluesky. @becklab.bsky.social Martin

We propose that the dilation state of #nuclearpores modulates its permeability and consequently fluid flow, which is important in response to osmotic stress or when cells squeeze through constrictions. Great collaborative effort by @pc_hoffmann @aobarska Henry Kim and @HummerLab

Difference between diffusion and flow? If you drip paint into a river it locally dissolves by diffusion. It goes downstream driven by flow. We quantify flow through #nuclearpores in response to rapid nuclear size changes. @MPIbp #TEAMTOMO @MolecularCell https://t.co/ccsTZiwtlQ

Nature research paper: In situ analysis reveals the TRiC duty cycle and PDCD5 as an open-state cofactor

… and perfect timing. Work by @HuaipengXing with @FrydmanLab out @Nature. PDCD5 binds virtually all open #TRiC, while closed TRiC forms clusters inside of cells. Congrats to all authors. https://t.co/5OX60e04zp

Congrats to @HuaipengXing for defending his PhD. First PhD hat @goetheuni 😎

Emotional leaving event for @Reiya_Tan1guch1 who is departing @MPIbp towards @riken_en. Best of Luck Reiya!

We modified our STED🔬to make it more efficient ('smart') to acquire high-resolution data of small and rare objects in a 3D cell volume. This enabled collecting a large amount of data in a fully automated fashion. With that, we visualized the ultra-structure a nuclear body👇🏻(1/3)

@JennySachweh Now online as a preprint https://t.co/uCPjcQrq6O. Thanks to the whole team for the productive collaboration! @MandyBoermel, @svenklumpe, @Reiya_Tan1guch1, @MartaKubanska, @WilflingFlorian

@JennySachweh Compartment-specific chaperoning and transport of peripheral Nups through the nuclear transport system control both the (a)symmtery of NPCs and explains how the cell can convert NPC precursors into functional NPCs upon relocation into the NE.

@JennySachweh Thus, (a)symmetry of NPCs is not determined by the structure of their core. Instead, the nucleotide state of the small GTPase Ran, a key component of the nuclear transport system, alters the binding of peripheral components in the nuclear and cytoplasmic environment.

@JennySachweh Nuclear envelope NPCs carry two different peripheral substructures on the nuclear and cytoplasmic side. Cytoplasmic NPCs carry two cytoplasmic rings, nucleoplasmic NPCs two nuclear rings. However, all comprise a core scaffold that is symmetric across the membrane plane.

@JennySachweh Nucleoplasmic NPCs exist in extensions of the inner nuclear membrane, and cytoplasmic NPCs in ER sheets can help the nuclear envelope grow! Using in situ cryoET, we find that such ectopic NPCs are symmetric across the membrane plane - in contrast to NPCs on the nuclear envelope.

Did you know that nuclear pore complexes can turn up outside the nuclear envelope? Studying these, @JennySachweh, Bernhard Hampoelz and others uncover that the surrounding cellular milieu determines NPC composition via the nuclear transport system itself. #teamtomo #NPC A 🧵

🙋🏻🔬 #EMBOinsitu is open for registrations! From cryo-EM to multi-scale modelling - what types of biological questions can be addressed using in situ structural biology? 📜 Submit abstract by 12 Nov 📅 4 – 7 Feb 2025 📍 EMBL Heidelberg and Virtual ➡️  https://t.co/zO2QG19gpX

Ready to lead your own research team-?😎The Max Planck Society offers you the chance to head an independent Research Group at a participating Max Planck Institute of your choice - the next open topic call starts on Sep 9, 2024. Stay tuned for updates!🌟 https://t.co/FJME2GLVVc

#PhD, #DnD(?) & #postdoc positions in “theory and methods for non-equilibrium atomistic simulations of complex #biomolecules” – Interested in theoretical and computational #biophysics? Check out the #JobAlert & apply here ⬇️: Shares welcome! #hiring #job https://t.co/ZJF97wtVnJ

We recently discovered a priority code in presequences of mitochondrial precursors. Some are much ‚stronger‘ than others because they specifically recruit Hsp90 cochaperones and make use of Tom70. Very unexpected, at least for us. You can read the preprint https://t.co/rvRDPTC6Gc

Incredibly proud of Matthias Mann for winning this year's Dr. H.P. Heineken Prize for Biochemistry and Biophysics together with Ruedi Aebersold! Their pioneering work has transformed protein research and is reshaping the future of biomedicine! #proteomics https://t.co/vDPWkqDH8k