John Briggs
@BriggsGroup
Followers
5K
Following
39
Media
26
Statuses
131
Briggs group at MPI Biochemistry. Cryo-EM, tomography, subtomogram averaging, CLEM, coated vesicles, enveloped viruses.
Martinsried, Germany
Joined July 2016
Our work on HIV-1 matrix, led by James Stacey and Dominik Hrebik @F4ustus, is in this week's @Nature. Extended explanatory video from @MargotRiggi.
1
63
217
RT @MPI_Biochem: Our #cryoEM technology group with scientists from the MPI of Biophysics and @viennabiocenter, used #cryoET to capture retr….
0
16
0
SP2 is sufficient for matrix maturation, and without it HIV-1 fuses more slowly with target cells. Collaboration with Kräusslich and Müller labs @CiidHeidelberg, Mothes lab @YaleMicroPath, @RobDickLab and Kun Qu. Read the full paper @Nature here:
nature.com
Nature - A study reports that the structural maturation of the matrix domain of the Gag protein of HIV-1 is induced by the proteolytic release and binding of the spacer peptide SP2.
0
1
36
Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @MargotRiggi :
1
82
295
From @ZunlongKe, collaboration with @PeacockFlu @CrollTristan @Dr_Shepp @AbhayKot @influenzal @wendybarclay11.
Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants.Cryo-electron microscopy and tomography reveal spike protein structural variation in intact virions from multiple SARS-CoV2 variants.@BriggsGroup @MPI_Biochem.
0
11
38
A physical model for M1-mediated influenza A virus assembly. A combination of #cryoEM and theoretical modelling from @jpeukes and @bio_physics. Preprint here:
biorxiv.org
Influenza A virus particles assemble at the plasma membrane of infected cells. During assembly all components of the virus come together in a coordinated manner to deform the membrane into a protru...
3
17
43
RT @MPI_Biochem: We are seeking expressions of interest or nominations for a position as a Director of a Scientific Department at the Max P….
0
19
0
RT @MPI_Biochem: You are a lab technician or technical assistant interested in electron microscopy? . We are looking for you @BriggsGroup a….
0
7
0
RT @MPI_Biochem: You are a talented research scientist, postdoc or engineer in electron microscopy?.We are looking for you @BriggsGroup and….
0
9
0
RT @SimonErlendsson: Extremely happy to share our preprint on the Ultrastructural Dynamics of Dopaminergic Presynaptic Release Sites reveal….
biorxiv.org
Dopaminergic neurons are fundamental in governing motivation, movement, and many aspects of cognition. The targeted modulation of dopaminergic signaling serves as a cornerstone in developing therap...
0
8
0
RT @MPI_Biochem: ❕REMINDER: application deadline April 11. We're looking forward to your application!.
0
6
0
RT @MPI_Biochem: We are seeking outstanding researchers for group leader positions, including through the tenure track Lise Meitner Excelle….
0
19
0
A coopted retrotransposon gene forms virus-like capsids associated with paraneoplastic neurological syndrome. Thanks @JunjieXu15 @JasonSynaptic @CedricFeschotte et al for a fascinating collaboration. Structures by @SimonErlendsson. @MRC_LMB @MPI_Biochem.
2
23
103
Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants. Preprint from @ZunlongKe in collaboration with @PeacockFlu @wendybarclay11 @AbhayKot @CrollTristan and others.
biorxiv.org
The evolution of SARS-CoV-2 variants with increased fitness has been accompanied by structural changes in the spike (S) proteins that are the major target for the adaptive immune response. Single-p...
0
14
48
Come and join us!.
You are an expert in transmission #electronmicroscopy with a technical background and are interested in an exciting position that combines research and methods development?. We have a #jobfor you!.❕apply until August 24.❕ #hiring #cryoem @BriggsGroup
0
12
24
We are looking for a postdoc to work on theory and computational methods for "in situ" cryo-EM. More details here:
mpg.de
Job offers of the Max Planck Society and Institutes. You can combine the "jobtype" with either "research subjects" or "region". Confirm your choice with OK.
0
24
37
RT @MPI_Biochem: 📣 The MPG starts the MPG Free Floater Program 2023! . Take the chance to become a #MaxPlanckResearchGroupLeader with fundi….
0
16
0
RT @Sveta_Dodonova: Join my brand new lab at @EMBL Heidelberg as a research technician! Experience in molecular biology and/or microbiology….
0
35
0
Structural studies of enveloped viruses / Mechanisms of membrane trafficking vesicle assembly: 2 #Postdoc positions @MPI_Biochem combining #CryoET, biochemistry and whatever else it takes.
2
36
84