Ryan Potts
@pottslab
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VP & Head of Induced Proximity Platform, @Amgen | Scientist | Father
Thousand Oaks, CA
Joined January 2014
New print posted from the group @Amgen. We describe VIPER-TACs that leverage viral E3 ligases for disease-specific targeted protein degradation. This concept dramatically expands he druggable space to include pan-essential proteins. 🧵 #mycompany
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🎓 Recent STEM grad? Jump-start your PhD journey with Amgen’s new 2-yr paid Postbaccalaureate Research Fellowship in Thousand Oaks! Work with world-class scientists, publish your findings, and make a real impact for patients. Apply by July 15 ➡️
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RT @DanNomura: Happy to present our latest paper with @pottslab & @Amgen in @J_A_C_S by co-first authors @C_M_Zammit & Cory Nadel on the d….
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Very cool!.
Molecular surface mimicry enables CRBN to target G3BP2 for degradation #biorxiv_molbio.
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DEL is accelerating our Induced Proximity Platform—helping us discover small molecules that rewire cellular processes and bind challenging targets. A powerful example of DNA driving therapeutic innovation. #DNADay #MyCompany.
Our DNA-Encoded Library (DEL) platform 🧬 is accelerating drug discovery by rapidly identifying molecules that have the potential to become therapies. This #DNADay, discover how we’re using DNA to advance therapeutics for those in need 🔗:.
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RT @biorxiv_biochem: Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules #biorxiv_biochem.
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RT @biorxiv_molbio: Bacterial ubiquitin ligase engineered for small molecule and protein target identification #bio….
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RT @CellChemBiol: .@pottslab @Amgen demonstrate proof-of-concept of disease-specific targeted degradation by redirecting virally encoded E3….
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RT @HartungIngo: Congrats to the teams @Amgen & @PlexiumTx for an impressive piece of work. After work by Novartis now providing additional….
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We anticipate that unbiased phenotypic screening in combination with biased E3-focused small molecule libraries will continue to be a fruitful approach to molecular glue discovery. This amazing work comes from a large team at @Amgen in collaboration w/ @PlexiumTx. Congrats to all.
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SAR analysis provided the opportunity to directly test the impact of altering k-on and k-off rates, which revealed that slow k-off as far more important than fast k-on for degradation activity. 7/8
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Comprehensive mutational analysis revealed the GEMIN3 degron by which dGEM3 mediates recognition by VHL. 6/7
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We extensively characterize the properties of dGEM3 to show biochemical reconstitution of the VHL:dGEM3:GEMIN3 ternary complex and ubiquitination consistent with a molecular glue without pre-existing affinity between VHL and GEMIN3. 5/7
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Proteomics analysis reveals dGEM3 is a highly selective degrader and the direct target is the SMN complex protein GEMIN3. 4/7
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We discover dGEM3 as a VHL-based molecular glue causing significant gene expression changes. 3/7
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We use an innovative gene expression read out approach to do target-agnostic screening of a focused 26,000 VHL ligand library for molecular glue degraders. 2/7
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Check out this cover highlighting @Amgen postdoc Kyle Mangano’s work on VIPER-TACs! 🐍.
The March issue of Cell Chemical Biology is out! Click here to read it: #condensates #ferroptosis #lipids #VIPER-TACs #PRDX #ergothioneine #proximity #syntheticbio
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