Quinn Cowan, PhD
@Quinn_Cowan_sci
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Genome editor | Biochemistry and Molecular Biophysics PhD | Conklin lab @GladstoneInst | Previously @KomorLab @UCSanDiego 🧬🔬
La Jolla, San Diego
Joined May 2019
Excited my PhD work is out now @NatureBiotech!. We report Multiplexed Orthogonal Base Editor (MOBE) systems: tools to simultaneously install distinct point mutations. MOBEs introduce co-occurring genetic variants (polygenic disease, haplotypes)🧬. 🧵⬇️ 1/
www.nature.com
Nature Biotechnology - Multiplexed orthogonal base editing systems introduce different point mutations at two loci simultaneously.
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RT @SternbergLab: 1/10 Today in @ScienceMagazine in collaboration with @liugroup we report the development of a laboratory-evolved CRISPR-a….
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RT @TheConklinLab: The Conklin Lab is hiring! We are seeking a Research Associate I to support ongoing projects focused on DNA repair and….
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RT @NatureBiotech: Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations .
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RT @pdhsu: Today we report Evo, a generalist foundation model for biology, on the cover of @ScienceMagazine. Trained on billions of DNA nuc….
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RT @AdityaRaguram: Excited to share our new system for evolving eVLPs with improved production and protein delivery efficiencies! Grateful….
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RT @chang_c_liu: Attention gene editors! We are searching for faculty in gene editing (broadly defined) at UC Irvine: .
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RT @GallowayLabMIT: So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each cons….
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RT @BKleinstiver: *Efficient PAMless base editing in patient-derived HSPCs* 🧬🖌️. For a few years now, we've been c….
www.science.org
Versatile PAMless CRISPR base editors enable efficient and precise therapeutic correction of CGD mutations in hematopoietic stem and progenitor cells.
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RT @mike_tilapia: Our latest paper is out! In collaboration with @DrAnneCarpenter, we conducted a systematic high-content screen to underst….
www.cell.com
Pathogenic missense variation can affect protein function in many ways, but the role of protein mislocalization has not been systematically assessed. By characterizing the localization of 3,400...
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RT @GladstoneInst: Saisha loves chess and singing. She is also affected by Charcot-Marie-Tooth disease, a genetic neuropathy that causes pr….
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RT @FumiakiIto110: Check out our latest study on the DNA polymerase theta (Polθ), a precision oncology target for HDR-deficient cancers. Ou….
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RT @jcornlab: Having a hard time with #CRISPR HDR? Your cells might be fighting against you! TREX1 nuclease, high in some cells, eats up HD….
www.nature.com
Nature Biotechnology - Homologous recombination in CRISPR–Cas9 genome editing is increased by blocking an exonuclease activity.
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RT @stanleyqilab: Excited to share 'frugal' CRISPRkit, a gene editing tool for K-12 education! Developed almost entirely by high school and….
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RT @naturemethods: Research Highlight by @madhuramukho: Multiplexed Orthogonal Base Editor (MOBE) systems developed by @komorlab, @quinn_co….
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Check out this great summary of our work "MOBE: A Base Editor That Multitasks without Mix-ups" by @TheScientistLLC @aparnanathan featuring @sahakris @KomorLab 🧑‍🔬🧪@UCSDChemBiochem @UCSDPhySci
www.the-scientist.com
A new system for simultaneous genomic edits could unlock better models of complex diseases.
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Thank you @naturemethods @madhuramukho for highlighting our research: Development of Multiplexed Orthogonal Base Editor (MOBE) systems! 🧬@KomorLab @UCSDChemBiochem @UCSDPhySci
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RT @katecrawdaddy: So excited to share one of the final works from my PhD in @SethShipman’s lab with @Asim_g_Khan and @oso_de_antojos, wher….
www.biorxiv.org
The bacterial retron reverse transcriptase system has served as an intracellular factory for single-stranded DNA in many biotechnological applications. In these technologies, a natural retron...
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RT @NatureBiotech: MOBE: A base editor that multitasks without mix-ups #NBTintheNews via @TheScientistLLC
www.the-scientist.com
A new system for simultaneous genomic edits could unlock better models of complex diseases.
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