Chang Liu
@chang_c_liu
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Prof. at UC Irvine developing specialized genetic systems for rapid evolution, protein engineering, and biology at large. Also at https://t.co/kZkXB08bHK
UC Irvine
Joined July 2014
Important paper from Jason Chin's and Julian Sale's labs realizing key operations needed for building synthetic human genomes. My repeated reaction reading this paper was "um, I didn't know you could just do that."
science.org
The synthesis of human genomes and other gigabase-scale genomes will require new strategies. Here, we realized key steps in our pipeline for building synthetic human chromosomes. We established: (i)...
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How can we make serum marker tests more sensitive? We show that editing markers in vivo to reduce their half-life can provide more sensitive measurement of gene expression dynamics. Congrats to @Shinouraein and the rest of the team. New study out in PNAS: https://t.co/ZqQib9MG9f
pnas.org
Gene expression in the brain is typically evaluated using invasive biopsy or postmortem histology. Serum markers provide an alternative way to moni...
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Impressive work from the Zhang group at Tsinghua University describing automated OrthoRep-driven protein evolution, which they used to evolve various new proteins, including an effective capping-enzyme-T7-RNAP fusions for production of capped mRNAs.
nature.com
Nature Chemical Engineering - This study reports on an industrial-grade, large-scale, all-in-one integrated and automated laboratory (iAutoEvoLab), combined with a genetic circuit-controlled,...
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📢 Our Dept. of Systems Biology @Columbia has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate. Apply: https://t.co/hQPKFkLB3c Suggested deadline: Dec 15, 2025. @ColumbiaSysBio
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Our Center for Human Genetics & Genomics at NYU is recruiting new faculty investigators:
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Tonight’s episode of @60Minutes will include a segment on the impact of federally funded science and recent cuts to science funding. Our lab’s development of base editing and prime editing and their clinical applications will be among the work described in the episode.
paramountpressexpress.com
Airs 7:00-8:00 PM, ET/ PT on the CBS Television Network and Paramount+ THE FAMILY FARM – American farmers have faced months of uncertainty after China s
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💡 Excited to introduce Kosmos, an AI scientist system for data-driven discovery! Kosmos is a multi-agent system designed around a central “world model” to coordinate information across hundreds of scientific agent instances. Given an open-ended objective and dataset, Kosmos can
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ODesign: A World Model for Biomolecular Interaction Design | Odin Zhang et al. - "ODesign allows scientists to specify epitopes on arbitrary targets and generate diverse classes of binding partners with fine-grained control. Across entity-, token-, and atom-level benchmarks in
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Announcing our new protein design server https://t.co/uu4co1sHhq: • End-to-end protein design for everyone! • Analyze your generated library interactively and on 3D structures • Export codon-optimized DNA sequences for experimental testing. Developed in collaboration
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OpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇
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I am delighted to share this work, led by Miguel Alcantar and done in collaboration with Amgen, on the OrthoRep-driven evolution of computationally designed minibinders. Here, we focus not only on getting to high affinity, but also on mapping sequence-affinity landscapes of
biorxiv.org
Computational protein design enables the generation of binders that target specific epitopes on proteins. However, current approaches often require substantial screening from which hits require...
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BoltzGen is a wonderful achievement offering general binder design for complex and new targets beyond the usual suspects. We are very excited to use this as the starting point in upcoming protein engineering experiments and are happy to have contributed in a small way to the
Excited to release BoltzGen which brings SOTA folding performance to binder design! The best part of this project has been collaborating with many leading biologists who tested BoltzGen at an unprecedented scale, showing success on many novel targets and pushing its limits! 🧵..
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Ut southwestern is recruiting! 3-milly start-up for tenure-track or tenured positions in O’Donnell Brain institute. Basic and translational neuroscientists both. If I can call myself a neuroscientist, so can you! Please consider reposting :) #DPRITisComing
The OBI Scholars Program is recruiting early career scientists of ANY discipline whose research includes mechanistic studies that advance understanding of CNS disease & aging. Scholars receive a generous ~$3M recruitment package and lab space. Learn more: https://t.co/XfBJXBhdVV
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Amazing work! Congrats to the whole team.
Many of the most complex and useful functions in biology emerge at the scale of whole genomes. Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵
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A friendly reminder that the Central Dogma is NOT "DNA -> RNA -> protein." All that Francis Crick *actually* said was: “Once information has got into a protein it can’t get out again.” This negative statement — namely, that some transfers of information seem to be impossible —
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I'm very sad to learn of Prof. Andrew D. Hanson's passing. Andrew was a pioneering plant (synthetic) biologist and was full of insight, clarity of thought, and vision. He was also exceptionally kind and wise. I will cherish the interactions and collaborations we've had together.
blogs.ifas.ufl.edu
Honoring Dr. Andrew D. Hanson, Eminent Scholar and UF Hort Sci Professor, whose visionary research and mentorship shaped plant biology.
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The search is still open and we are actively reviewing applicants
Multiple faculty positions open in RNA science at UF Scripps (Asst/Assoc/Full Prof) in Jupiter, FL—part of a major investment in RNA research. Apply: https://t.co/mFL3eyzlI9 Center info: https://t.co/ZA0nXRpbuD Please retweet!
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RT @xiongyih: Another exciting milestone in biocatalysis with nonheme enzymes! We have developed the first enzymatic system for copper-cata…
science.org
Copper-catalyzed radical C(sp3)‒N coupling has become a major focus in synthetic catalysis over the past decade. However, achieving this reaction manifold by using enzymes has remained elusive. In...
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