Chang Liu
@chang_c_liu
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Prof. at UC Irvine developing specialized genetic systems for rapid evolution, protein engineering, and biology at large. Also at https://t.co/kZkXB08bHK
UC Irvine
Joined July 2014
RT @xiongyih: Another exciting milestone in biocatalysis with nonheme enzymes! We have developed the first enzymatic system for copper-cata….
science.org
Copper-catalyzed radical C(sp3)‒N coupling has become a major focus in synthetic catalysis over the past decade. However, achieving this reaction manifold by using enzymes has remained elusive. In...
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Our new company, K2 Therapeutics, is off to the races to develop antibody drugs that target multipass membrane proteins. We are hiring so check us out!
k2-tx.com
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Happy to see this new T7 replicon based orthogonal replication system in E. coli. Congrats to the Diercks and Schultz lab teams at Scripps Research!
science.org
Systems that perform continuous hypermutation of designated genes without compromising the integrity of the host genome can substantially accelerate the evolution of new or enhanced protein functio...
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RT @ryanayork: Biological foundation models have hit a plateau. Scaling isn't working as expected. Foundational concepts from evolutionary….
research.arcadiascience.com
Biological foundation models are, at their core, evolutionary comparisons on massive scales. As with all comparative studies, evolutionary nonindependence determines their power. We chart how this...
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We find that low copy number accelerates fixation of beneficial mutants while high copy number lets more deleterious alleles hitchhike in cells with fit alleles. High copy number also promotes a form of functional robustness through maintenance of allelic diversity.
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Happy to share this work, led by Olek Pisera, on dialing in a wide range of copy numbers for the orthogonal plasmid of OrthoRep. We used this ability to study how plasmid copy number influences evolutionary outcomes.
nature.com
Nature Ecology & Evolution - In an experimental multicopy plasmid evolution system that allows manipulation of mutation rate and copy number, low copy number promoted enrichment of beneficial...
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RT @AlissaHummer: Our work exploring the ability of and requirements for ML to predict the effects of mutations on antibody–antigen binding….
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RT @uci_bme: Thank you to everyone who attended the 25th Annual UC Systemwide Bioengineering Symposium last week at UC Irvine! https://t.co….
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RT @SternbergLab: Our latest story is now online @Nature! We discovered a phage defense system that deploys kilobase-long DNA homopolymers….
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RT @davidrliu: I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthro….
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Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to @yuichi_furuhata, a true master bioengineer, on leading this excellent work!
nature.com
Nature Communications - Genetic code expansion (GCE) enables the incorporation of new amino acids into proteins. Here, authors demonstrate the rapid OrthoRep-driven evolution of aminoacyl-tRNA...
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RT @nooryoussef03: 🚨 New in @ImmunityCP !.EVE-Vax, an AI model that anticipates future viral evolution and designs antigens to proactively….
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RT @WeiGaoLab: New in @ScienceMagazine, we present DISP—an imaging guided deep-tissue in vivo sound printing platform that allows spatiotem….
science.org
Three-dimensional printing offers promise for patient-specific implants and therapies but is often limited by the need for invasive surgical procedures. To address this, we developed an imaging-gui...
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Going forward, we’ll be using this system, ORACLE (OrthoRep Assisted Continuous Library Evolution), to find evolutionary innovations from more libraries against more additional selection pressures in service of both the basic understanding of gene evolution and applications.
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We hope the abundance of examples we provide where unexpected genes evolve new function will update views on the likeliness of originating new biomolecular functions in nature.
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. when the diversity of genes available as sources of new function is large and when the systems level complexity of cells is available to afford multiple routes to new selectable phenotypes.
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We’re excited to share new work on the continuous in vivo evolution of gene libraries towards arbitrary functions. Led by superstar Olek Pisera, our experiments show that gene evolution is highly versatile.
biorxiv.org
The emergence and evolution of new gene functions is central to biology, yet experimental tools that allow us to prospectively probe and understand this process are lacking. While systems for...
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