Linhan Wang
@Linhan_W
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Postdoc in Shipman lab at Gladstone, Molecular recording & Genome engineering || PhD Cell biology, Biochemistry on membrane protein degradation. Keep curious.
San Francisco, CA
Joined April 2022
Been working on a really strange retron bacterial immune system, here's the preprint: https://t.co/iWP8qH1Fe7 Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
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Check out MitoScribe, our new preprint led by @Linhan_W: https://t.co/rvNOSaMily... It's an analog molecular recorder that uses neutral base edits to the mitochondrial genome to store info about historical signaling in a cell. Single cell resolution at scale (see next post)!
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A team at Gladstone developed a technology that lets them edit the genomes of bacteria-fighting viruses, known as phages, in a streamlined and highly effective way. @seth_shipman
@katecrawdaddy
@ChloeFishman
@NatureBiotech
@UCSF
@UCSF_BTS
@czbiohub
https://t.co/Dkfk5cGMGT
gladstone.org
Scientists at Gladstone Institutes develop a streamlined and rapid way to engineer bacteria-fighting viruses known as phages
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Finally! A happy ending of my graduation work. Thanks to all the people who contributed to our work.
Online Now: TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation
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Online Now: TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation
cell.com
Wang et al. found that TMUB1 binds to p97 ATPase and facilitates p97-mediated membrane protein extraction from the endoplasmic reticulum (ER) membrane during ER-associated degradation. TMUB1 chaper...
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