Thrilled to share my primary PhD work: a Transcription Factor Atlas for understanding gene regulation and cell engineering @CellCellPress. We created a comprehensive TF ORF library and applied it to profile resulting expression changes. A thread 1/X

Our GDE preprint now accepted to #NeurIPS2025! 🎉 We show how to lift any encoder-decoder to learn representations of distributions not just datapoints—unlocking multiscale modeling across domains: from cell populations to DNA methylation to viral evolution. Try GDEs for a

I'm thrilled to share our work from @JswLab ( https://t.co/CMzQznSXPN). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two mechanistically distinct strategies for mitochondrially localized translation.

Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors

Excited to announce that this work is now live as a first release article @ScienceMagazine So grateful for this fantatic team and to see this work in wild!

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress: Cell

Why do some genetic mutations devastate specific tissues while sparing others? We explore this question in GGC repeat disorders, revealing a mechanism linking protein aggregation to tRNA splicing failure in the brain. 🧵 on our new paper in Science: 🔗

Just published in Nature (June 2025), Andersen et al. (@EAChiocca, Reardon, @QuintanaLabHMS) developed a novel viral barcode interaction-tracing (RABID-seq) platform, uncovering previously unknown immunosuppressive interactions between astrocytes and glioblastoma (GBM) cells.

Repeat-element RNAs integrate a neuronal growth circuit: Cell

PAPER ALERT! Excited to share my PhD work in the lab of @larsplus @CRGenomica. We screened minimalistic synthetic enhancers throughout myeloid differentiation. We uncovered widespread dual activator-repressor functions for individual TFs and TF pairs https://t.co/D3XlH99RH7 (1/n)

Stem cell therapy for Parkinson’s disease has entered a new era. Two @Nature studies demonstrate that pluripotent stem cell–derived dopamine neurons can survive, restore function, and potentially change the treatment paradigm for this neurodegenerative disease.

Inserting large, scarless DNA sequences is a major hurdle for gene therapy. We explored if site-specific retrotransposons, natural genome editors found across the tree of life, could be engineered for this task. Excited to share STITCHR in @Nature with @jgooten!

This is the most important paper in the circadian field in over a decade. A completely new clock component that is evolutionarily conserved. @Eric_E_Zhang @susanksgolden @ @SRBR_Outreach https://t.co/Gh8fUhDeP7

What protects individuals from developing blood cancers? Thrilled to share my work in @bloodgenes lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇(1/n) https://t.co/PNaCHa4D4k

The massive changes in US research brought about by the new administration of President Donald Trump are causing many scientists in the country to rethink their lives and careers https://t.co/cWGoHyeewI

The latest from @GladstoneInst of Cardiovascular Research and @ucsf: Isha Jain's lab, with an outstanding discovery of a small molecule that mimics hypoxia, to treat neurodegenerative diseases. The amazing Sylar Blume, RA in Isha's lab, is first author!

Thrilled to be launching @terrainbiosci today! Revolutionizing RNA medicines with our AI-powered design & manufacturing platform Helping biotechs get better mRNA candidates to patients, faster 🧬 #biotech #RNAmedicine w/ @jgooten @pdhsu Chetan and many others (awesome team!)

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis

Big #RegenerativeMedicine advance! New study demonstrates the use of iPSC-heart muscle to treat a patient with heart failure. The patches successfully engrafted, contributing to heart repair. Patient survived 3 months before receiving a heart transplant

Super excited to share our new study from the @JD_Buenrostro Lab in @Nature! We developed a computational method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning. Paper:

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time