Lamming Lab
@LammingLab
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All views solely of Dr. Lamming and do not necessarily reflect views of my employers, funders, or societies. Retweet≠Endorsement. @LammingLab @fediscience .org
Wisconsin, USA
Joined April 2015
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I am delighted to be able to share the latest study from the
@LammingLab
, “Fasting drives the metabolic, molecular, and geroprotective effects of a calorie restricted diet in mice,” a multi-year study led by graduate student
@pak_heidi
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I am very pleased today to announce our new manuscript "The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine"
22
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May the
#rapamycin
be with you! Pleased to be able to announce our new review on "Targeting the biology of aging with
#mTOR
inhibitors" with
@MannickJoan
now available at
@NatureAging
. Free-to-read link now available at
2
45
173
I am delighted to be able to share the latest study from the
@LammingLab
, “Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice” led by postdoctoral fellow
@garacreen
10
38
172
Very happy to announce our lab’s latest publication on a novel mTORC1 selective rapalog, with great collaborators including
@sebuy
@BKennedy_aging
and Aeonian Pharmaceuticals
#mTOR
#rapamycin
13
55
169
Our new paper, "Calorie Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension" is now out! Congrats and thanks to everyone in our lab working hard to decipher how a CR diet works!
7
52
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I am extremely pleased to present our new in-depth review of dietary restriction with
@garacreen
and
@LuigiFontana22
, "Molecular mechanisms of dietary restriction promoting health and longevity"
2
38
162
A whitepaper from a NIH workshop on "Dietary Composition, Time-Restricted Feeding and Associated Metabolic Reprogramming in Healthspan and Longevity Regulation" is now out in
@Cell_Metabolism
. Thanks to all the co-authors especially
@MariaMMihaylova
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It's beyond time to rigorously test the hypothesis that
#mTOR
inhibition can safely promote healthy aging in humans. With
@maml_UWMadison
and many other clinical & translational researchers
@uw_medicine
, over the next three years we will find out!
#rapamycin
@agingdoc1
Beyond excited to announce the official NOA for our NIA funded study "Clinical Evaluation of mTOR inhibition for Geroprotection." It is an honor to be PI of this project and have the opportunity to work with an amazing cast of collaborators and trainees to test if a....
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I am delighted to be able to share the latest study from the
@LammingLab
, “Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction,” led by Glenn/
@AFARorg
supported postdoctoral fellow
@garacreen
.
8
31
130
Excited that our lab's new research on how dietary BCAAs affect healthspan and longevity is now out! Congrats to first author
@NRichar_
and all the other
@LammingLab
authors including
@pak_heidi
!
#aging
#mTOR
Tweetorial to follow!
In the launch issue of
@NatureAging
, the
@LammingLab
@uw_medicine
reveal that there are sex-specific differences in whether or not protein restricted diets lacking branched chain amino acids promote healthspan and longevity in mice. Read it here:
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5
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Delighted to share our new review, written with
@JudithSimcox
, on "The central moTOR of metabolism" in
@Dev_Cell
with all of you!
@uw_medicine
@UWBiochem
1
31
113
It is my great pleasure to announce that I will be chairing the upcoming
@NIHAging
workshop on "Dietary Composition, Time-Restricted Feeding and Associated Metabolic Reprogramming in Healthspan and Longevity Regulation". It will be held virtually 10am-3pm EST on August 22 & 23rd.
1
30
111
Delighted to share
@garacreen
's N&V, "We are more than what we eat" today in
@NatMetabolism
! A personalized approach to nutrition, aging and metabolism is critical & relevant to recent discussions w/
@mkaeberlein
@agingdoc1
@JohnSpeakman4
@DrMorganLevine
1
27
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An entirely new paradigm for the regulation of mTORC1 is coming, addressing long-standing questions about where and when mTORC1 acts on diverse substrates. Congratulations
@DemetriadesLab
!
2
25
107
As promised, a brief tweetorial on our new work "Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and life span in mice" published yesterday in the inaugural issue of
@NatureAging
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Congratulations to our lab's newest Ph.D., Dr. Heidi Pak!
@pak_heidi
Thanks to all her committee members including
@AndersonRozalyn
and lab members who helped make this possible!
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2
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Our article demonstrating "The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine" is now officially published and a Featured Article in the May issue of
@Cell_Metabolism
focused on diet and exercise!
2
26
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I am pleased to announce that our new Nature Protocols paper "A toolbox for the longitudinal assessment of healthspan in aging mice" - with collaborators around the world including our fearless leader
@IBellantuono
- is now available.
5
29
96
I am very pleased today to announce our new manuscript " Regulation of metabolic health by dietary histidine in mice " published in
@JPhysiol
,
6
16
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Our new paper is out today - "The Metabolic Response to a Low Amino Acid Diet is Independent of Diet-Induced Shifts in the Composition of the Gut Microbiome" Great work from many lab members including first author Heidi Pak!
1
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Looking for postdocs to undertake exciting new work in the Lamming Lab! We are a great team of researchers exploring the interaction between nutrition and aging using a team science approach. Check us out at and email me if you would like to hear more!
1
36
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Delighted to announce that our lab, co-PI
@JudithSimcox
, and our team of collaborators have received a
#UW2020
grant to establish core facilities in support of the new UW-Madison Comprehensive Diabetes Center!
@uw_medicine
We're proud to help support the
#UW2020
: WARF Discovery Initiative, which stimulates cutting-edge, highly innovative and groundbreaking research at
@UWMadison
.
#WisconsinInnovates
0
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Pleased to announce the renewal of our NIH/NIA BCAA R01, supporting our study of BCAAs in aging and age-related disease! Thanks to the efforts of everyone in the lab and our collaborators
@BaurLab
@JudithSimcox
and Irene Ong! Those interested in postdocs please DM or email.
9
3
76
Congratulations to Dr. Cara Green
@garacreen
, a postdoc in the
@LammingLab
who was awarded a 2020 Glenn Foundation for Medical Research Postdoctoral Fellowship in Aging Research!
9
5
73
Updating my giant table of rapamycin mouse studies for an upcoming review - please let me know if I have missed yours! (Figure also viewable as Table 1 here: ). Already know 2022 papers by
@AnastasiaShind
et al, Aiello et al., Tibarewal et al. and the ITP
4
23
74
Aging Science in Isolation is a GO for Wednesday and the following 5-6 weeks (at least)! Thanks to all the speakers and to
@William_Mair
for setting up the Slack and
@AgingSciTalks
! Webex and Slack links can be found at
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Finally, we show that restricting calories without fasting does not promote healthspan and longevity and mice – indeed, it leads to a shorter lifespan.
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For those wondering about the potential side-effects of low dose
#rapamycin
: 1 of 9 dogs receiving low dose rapamycin (0.025 mg/kg M-W-F) during a RCT developed severe hypertriglyceridemia after 6 months on the drug that resolved after stopping rapa:
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Looking forward to speaking about our work today at the Harvard/Paul Glenn Virtual Symposium on Aging! Hope many will be able to join us from 1-6pm Eastern/12-5pm Central time. Thanks to
@davidasinclair
for the invitation!
1
9
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Many researchers talk about how an intervention in mice “extends healthspan” but how does one measure that? Well worry no more – we introduce two new summary statistics to measure healthspan in mice, FAMY and GRAIL!
1
20
69
Congratulations to
@garacreen
who today received the first
@uw_medicine
Research Fellow Award! Thanks also to
@JoshLangMD
and
@LynnSchnappMD
and the Research Committee for recognizing the contributions of our postdocs to UW-Madison and the Department of Medicine!
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2
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Delighted that
@pak_heidi
's work on fasting in the response to CR was highlighted today in
@NatureRevEndo
1
5
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Congratulations to
@LammingLab
postdoc Dr. Cara Green
@garacreen
, a Rising Star Invited Speaker at today’s Wisconsin Human Proteomics Symposium focused on “Omics in Precision Medicine”!
2
7
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Great time and great science at
#ardd2022
- and great to see these guys again
@timrpeterson
@PekkaKatajisto
! Thanks to
@ScheibyeKnudsen
and
@biogerontology
for the opportunity!
3
3
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Great summary of our lab's research on dietary protein and branched-chain amino acids now live: Thanks to former grad students Dr. Nicole Richardson
@NRichar_
and Dr. Deyang Yu for leading these projects!
@uw_medicine
@uwsmph
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9
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Coming to you live starting Wed. 3/17 at 1PM EST/12CST/10PST - Aging Science in Isolation! Full schedule of WebEx talks with link, and link to Slack (questions via Slack channel after talk) at
@AFARorg
@NathanShockCtrs
@geronsociety
@americanaging
6
28
61
Proud to announce our new paper "Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence"! Congratulations to
@spencerhaws
(Denu lab) who led the work, and Deyang Yu who led our labs contrib!
3
10
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@nursekelsey
Lot of stories going around about negative PCR results but Covid symptoms (and in UK a covid positive lateral flow test):
3
6
55
With the winter break almost upon us here at
@UWMadison
, it's time for the 2021
@LammingLab
year in review! Some of our accomplishments and successes are described in the thread below.
4
1
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Our new review article, "The regulation of healthspan and lifespan by dietary amino acids" authored by grad student
@RejiBabygirija
is now available! Thanks to
@senmorteco
for the invitation to write on this important subject!
#BCAAs
#methionine
#mTOR
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Proud to announce our new paper, "Hypothalamic mTORC2 is essential for metabolic health and longevity" with the Baur lab and
@KarthikeyaniC
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Wednesday, I was honored to receive the
@uw_medicine
Puestow Research Award. Thanks to all my colleagues, collaborators, postdocs, fellows, and students who help make our research possible!
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Proud to announce that our paper on "Regulation of metabolic health by dietary histidine in mice" is now officially in print - and selected as the "Editor's Choice" in this month's issue of
@JPhysiol
! Led by former grad student Dr. Victoria Flores with help from great collabs!
3
4
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Congratulations to
@garacreen
for winning the 2022 Orentreich Foundation Award for her presentation at
#AGE2022
! Picture does not necessarily represent the actual award.
1
4
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Very glad to announce that
@michaelamRD
and
@NRichar_
's terrific review, "Protein restriction and branched-chain amino acid restriction promote geroprotective shifts in metabolism" is now available in
@AgingCell
!
1
10
51
Thanks to all the hard work from everyone in the
@LammingLab
, we've got that NOA feeling - our R21 was funded!
3
1
50
Looking forward to tomorrow, and my first in-person talk in 594 days!
Don't miss the Nutrition and Aging symposium on July 20th, sponsored by
@Healthspan_OFAS
! Register now in person or virtually at:
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1
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Now offically published in eLife, graduate student
@michaelamRD
's excellent work on how "Resistance exercise protects mice from protein-induced fat accretion"
5
8
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Terrific time at
#AGE2022
- great to see so many friends and colleagues again, and looking forward to OKC next year!
@iCCup_Spec
@mariahcalubag
@garacreen
@michaelamRD
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It's 2020, so it must be time for a new mechanism of action for
#metformin
"We conclude that metformin is capable of causing lysosomal damage, a process that activates AMPK."
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49
Yesterday was not just our annual lab retreat (held jointly with
@JudithSimcox
lab this year), but the Lamming Decennial & Simcox Quinquennial Celebration! It is so hard to believe 10 years have gone by since that frigid polar vortex day I arrived at UW-Madison to open my lab.
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Looking forward to an in-person visit today
@NUFeinbergMed
! Looking forward to sharing our research and meeting with great scientists, including
@uw_medicine
alumnus
@mike_schaid
!
6
2
48
Today, I would like to talk about coffee, likely one of the most powerful geroprotective interventions out there, and some things I only recently learned about my own coffee consumption.
7
7
48
Thank you and Impetus Grants!
@JudithSimcox
and I looking forward to getting this project underway!
Monday morning in Fall 2021 = More Impetus Grants!
Today we're congratulating:
🪙
@LammingLab
,
@uwsmph
🪙
@mattpiperlab
,
@MonashUni
🪙
@sarahjayne189
,
@ETH_en
for awards to produce high-dimensional data to understand the interface of
#metabolism
and
#longevity
interventions.
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Delighted to be able to hood
@pak_heidi
and Victoria Flores today and escort them at commencement! Thanks to
@DawnDavisLab
and
@JudithSimcox
for helping to make this day special for everyone!
3
3
48
Thanks to the NIH National Institute on Aging, the
@LammingLab
and our collaborators are now funded to study Alzheimer's disease from a geroscience perspective during the next five years!
5
0
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Spurred in part by this poll by
@davidasinclair
, I am pleased to announce a preprint in which we define two new summary statistics, FAMY and GRAIL, enabling the quantification of healthspan in mice:
1
5
49
Postdoctoral and technician positions in the Lamming lab are available for researchers interested in studying how what, when, and how much we eat regulates healthy aging using mouse models. Check us out and then email or DM!
1
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Just in time for the holidays, our new article in J Physiol, "Restoration of metabolic health by decreased consumption of branched-chain amino acids".
2
23
47
Free to read link for our new study:
Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice
@garacreen
@JudithSimcox
@LammingLab
@Cell_Metabolism
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Very excited to be invited by
@ScheibyeKnudsen
,
@biogerontology
, Daniela Bakula, and the other organizers of this incredible conference to present at the 9th Aging Research & Drug Discovery Meeting 2022
#ARDD2022
this summer!
@ARDD_Meeting
2
2
47
Delighted to share with you a new review preprint on my thoughts about
#Rapamycin
, Rapalogs and
#mTOR
inhibition for possible use as as geroprotectors.
0
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1
4
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Reading about the latest in calorie restriction this evening, I discovered that a very well known aging researcher may be known under another name - and much chronologically older than he appears! Happy belated 124th birthday,
@davidasinclair
! (Not PS, google "Clive McCay").
9
1
46
Check out "mTOR gets greasy: lysosomal sensing of cholesterol"! A pleasure to write this perspective (with
@LironBarPeled
) on
@RobertoZoncu
,
@LaplanteMathieu
and colleagues recent discoveries:
5
4
47
A first for me: our story on isoleucine restriction and lifespan made the front page of
@Reddit
! Kudos to the
@UWMadScience
team for their engaging story about
@garacreen
's paper.
3
4
46
Hi all -
@DrMorganLevine
@LeonidG77901288
and I (
@LammingLab
) will taking on "Is aging a disease" today. I will be taking the affirmative (a minority position polling at aging conferences would suggest), and I think
@DrMorganLevine
and
@LeonidG77901288
will be taking the negative
14
3
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Excited to report "Resistance exercise protects mice from protein-induced fat accretion" is out today as a Reviewed Preprint in
@eLife
! Paper led by grad student
@michaelamRD
!
7
10
45
@jpsenescence
@RapaNews
@altos_labs
I don’t see why altos labs would get the credit for work done by researchers at Genentech and the Salk just because one of the corresponding authors (but neither of the first authors) now works there?
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Shamelessly riffing off this idea, who wants to participate in a new “Aging In Isolation” seminar series? DM me!
@DrEmilyGoldberg
@davidjglassMD
@davidasinclair
@colinselman1
@labmccormick
@AndersonRozalyn
@MariaMMihaylova
@sadagurski
@MattYousefzadeh
@mkaeberlein
@BrunetLab
7
9
43
With the winter break almost upon us, it's time for the 2020
@LammingLab
year in review! Some of our accomplishments and successes are described in the thread below.
3
2
42
Meet Dr. Yu, the first graduated Ph.D. student of the Lamming Lab!
4
0
43
Tomorrow at
@AgingSciTalks
please join us at 1pm EST for
@RobertoZoncu
presenting on “Molecular mechanisms of lysosomal mTORC1 signaling”!
0
14
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@arjunrajlab
Ask the editor to re-consider your original submission for back to back publication?
2
0
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With the end of the year upon us, it's time for the 2023
@LammingLab
year in review! Some of our accomplishments and successes are described in the thread below.
3
7
42
I see the time has come to once again discuss the potential use of
#rapamycin
for diseases of aging. There is as usual a lot of enthusiasm, but I will once again note that we don't know that this compound can be used safely.
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9
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For anyone who, like me, missed it when it first came out: Leucine supplementation does not extend the lifespan of mice.
3
1
42
Our manuscript "Regulation of metabolic health by dietary histidine in mice" is now formatted and freely available in HTML and PDF formats. Get your copy today!
@JPhysiol
1
8
41
Interested in doing a postdoc in the Lamming Lab? Potential openings for a T32-eligible candidate Sept 2020 and Spring 2021. Email or DM if interested!
0
27
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Really cool new paper "The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency" at
@Cell_Metabolism
! An entirely new way in which mTOR senses AA deficiency Thanks
@pak_heidi
for pointing out this one.
0
8
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Cool new biomarker for aging in humans and mice:
0
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“These data show that rapamycin may have a negative impact on the skeleton of adult mice that should not be overlooked in the clinical context of its usage as a therapy to retard aging and reduce the incidence of age-related pathologies.” Interesting
Rapamycin impairs bone accrual in young adult mice independent of Nrf2
4
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5
42
Still remember the conference where
@biogerontology
@mkaeberlein
and I were the only ones in the room who voted that aging is a disease. Glad to see there have been some converts in the last five years!
3
1
39
Looking for a job? Consider joining our team as we study how to modulate nutrient-sensitive signaling pathways to promote healthy aging. The job posting: and our website:
1
26
39
Hey aging biologists let’s start a thread for our handles on the new service. I’ll go first: lamminglaboratory
Pass it on
@agingdoc1
@BBParis1984
@davidasinclair
@BittoAlessandro
@JohnSpeakman4
@eatlikeanimals
@MirreSimons
@TheMAIRLab
@BKennedy_aging
21
12
39
Glad to see people still talking about
@pak_heidi
's research into how calorie restriction promotes healthy aging: original article:
0
4
40
Interested in joining an incredible team of aging researchers in the
@LammingLab
at
@uw_medicine
? A postdoctoral position is available on our institutional NIA T32 Training Grant! Learn more about our lab at:
0
33
39
Congratulations to
@mariahcalubag
for winning a Poster Pitch Award award for her presentation at
#AGE2022
!
0
4
39
Starting this Monday 6/1, the original US-based
@AgingSciTalks
(1pm ET/12pm CT/10am PT)) will be switching to twice-weekly talks on Tuesdays and Thursdays only! Hope you will still be able to join us as labs reboot! Links as always
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This
@AgingSciTalks
-inspired special issue of Translational Med Aging, guest-edited by
@LammingLab
and Dr. Christy Carter, is now online! Pieces by us,
@William_Mair
@The1HannahSmith
@DrDorotaSK
@JavierApfeld
and many more!
4
9
40
Joint
@LammingLab
@JudithSimcox
lab retreat is underway! Great presentations by
@iCCup_Spec
@mariahcalubag
@LainyVonBank
this morning!
3
4
39
Congratulation to lab member
@garacreen
, who received a UW-Madison Comprehensive Diabetes Center Core Services Pilot Award! Congrats as well to the other awardees, including
@timwrhoads
@EnginLaboratory
and
@HornbergerLab
!
0
6
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mTORC2 inhibition as potentially therapeutic in the brain! Similar to prostate findings by
@guertin_lab
and
@DMSabatini
in 2009 where PTEN induced defects also rescued by Rictor knockdown
“Using molecular genetics we unexpectedly found that genetic deletion of mTORC2 (not mTORC1) activity prolonged lifespan, suppressed seizures, rescued ASD-like behaviors and long-term memory, and normalized metabolic changes in CNS of mice lacking Pten”
0
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An unexpected and very nice Christmas present from John Furber - this photo of myself and Dr. Kelvin Davies, from November when I received the 2018 GSA Nathan Shock New Investigator Award. Thanks John!
0
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