Jess Davidson
@_JessDavidson
Followers
228
Following
1K
Media
34
Statuses
225
ultra runner + adventurer + metabolism nerd + first gen pursuing a PhD at UW Madison (she/her)
Joined April 2021
Excited to share our latest story on the regulation of lysosomal BMP lipids! Co-led with Raghav Jain, we show that PLA2G15 is a BMP hydrolase that regulates lipid levels under the transcriptional control of TFEB. @JudithSimcox @UWBiochem @HHMINEWS.
New! Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV
3
9
27
RT @JudithSimcox: Officially tenured. Thank you to all the mentors who guided me, and to the trainees who made this possible with your idea….
0
12
0
RT @JudithSimcox: Great work by Mugagga, @LainyVonBank and @_JessDavidson from the Simcox Lab! SCD1 is known to regulate the production of….
0
5
0
RT @EdreesRashan: As promised, a 🧵 on our recent article now out in @NatureSMB! Co-led with @AbbyBartlett_ @Pagliarini_Lab @JudithSimcox, w….
nature.com
Nature Structural & Molecular Biology - Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and...
0
22
0
30 mile ride to celebrate 30 weeks of pregnancy 💪🏼 pretty stoked with how this cell culture experiment is going so far!
0
0
6
RT @UWMadGSEd: Congratulations to Dr. Andrea Hunger on receiving the WISL Award for Communicating PhD Research to the Public! Dr. Hunger's….
0
2
0
RT @WeiWei_Stanford: My lab is recruiting a postdoc fellow to characterize new biochemical pathways that control taurine and glucose metabo….
0
125
0
5/ There are still many unanswered questions on PLA2G15 post-translational regulation and stereoisomer specificity for BMPs to be explored in the future. But this is a huge step forward for the field and I’m thrilled to be a part of such impactful, collaborative research.
0
0
0
4/ This is exciting, as PLA2G15 was identified as a BMP lipid hydrolase not only by us but also in recent work from our collaborators in the @abu_remaileh lab who further characterized PLA2G15 as a potential therapeutic target in NPC disease.
1
0
0
3/ We identified PLA2G15 as a target of TFEB; TFEB directly binds and suppresses transcription of Pla2g15 during cold exposure. Through knockdown, knockout, and rescue models in cells and mice, we determined that PLA2G15 degrades BMP lipids.
1
0
0
2/ As part of the metabolic adaptation to cold exposure, lysosomal lipid processing is altered and BMP lipid levels are increased in the liver. We found that this response is transcriptionally controlled by TFEB. Knockdown of TFEB leads to cold intolerance in mice.
1
0
0
1/ Localized to the lysosome, BMP lipids are known to mediate lipid and protein degradation. While they are critical to lysosomal function, there are still many unanswered questions regarding BMP lipid regulation.
1
0
0
Stoked for the opportunity to share some of my translational research with the Biochemistry community at the University of Utah next week!.
We will be welcoming nine talented Graduate Student Rising Stars to share their research with us on Monday May 19th, starting at 9:30am in HSEB 1730. The symposium will be followed by the Pace Keynote talk by Dr. Toto Olivera at 4pm!
0
4
11
RT @uwmadisonipib: Please join us on May 19 for Andrea Hunger's Ph.D. thesis defense! Hunger's research in the @JudithSimcox Lab examined t….
ipib.wisc.edu
Hunger’s research in the Simcox Lab examined the regulation of a lipid that controls cell death and insulin signaling.
0
5
0
RT @uwmadisonipib: Join us for Gina Wade's Ph.D. thesis defense on May 2! @JustWadeAMinute's research in the @JudithSimcox Lab examined the….
ipib.wisc.edu
Wade’s research in the Simcox Lab examined the role lipids play in regulating body temperature during cold exposure.
0
7
0
RT @WeiWei_Stanford: I'm beyond thrilled to announce that I will be joining the Biochemistry Department at the University of Wisconsin–Madi….
0
21
0
RT @dylan_duerre: Excited to share that work from my PhD thesis is now available in @NatMetabolism! Here, we uncover a link between heme pr….
nature.com
Nature Metabolism - Inhibition of haem synthesis is shown to lead to the accumulation of branched-chain amino acids in the brown adipose tissue of mice, which reduces UCP1 levels and impairs...
0
20
0
“I love the flexibility of working in science”, she whispers to herself as she rolls into lab on a weekend morning for the umpteenth time to do cell culture and check a mass spec run.
1
1
13
RT @scicommlab: Happy Native American Heritage Month! Celebrate and share with @JudithSimcox's inspiring journey:
sciencecommunicationlab.org
Biochemist Judith Simcox recounts her journey from battling cancer to rediscovering her passion for science, and becoming a mentor at the University of Wisconsin–Madison.
0
9
0