SunLab
@JiSunLab
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The Sun Lab | Dept. of Biological Science @ National University of Singapore
Joined September 2019
Happy to share our new publication on KCNQ1. In this work, we reveal a cool molecular mechanism that modulates the tissue-specific function of KCNQ1 through its beta subunits, KCNE1/3, which provides different voltage and PIP2 (GPCR) sensitivity for gating
nature.com
Cell Research - Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function
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A new paper from the #MacKinnonLab in @PNASNews finds that while Kv2.1 and EAG1 are from distinct architectural classes of voltage-dependent ion channels, the way the voltage sensors gate their pores is very similar. #RockefellerScience
https://t.co/h7UIKFFGlM
pnas.org
Gating in voltage-dependent ion channels is regulated by the transmembrane voltage. This form of regulation is enabled by voltage-sensing domains (...
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Congratulations, Hongbo!!!
We’re excited to announce Hongbo Chi, PhD, as the new Chair of the St. Jude Department of Immunology. His leadership will advance our mission to find cures for catastrophic childhood diseases.
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Our researchers, in collaboration with the Medical College of Wisconsin, have discovered how chemokines and G protein-coupled receptors (GPCRs) selectively bind to control how cells move. https://t.co/nGi6Ou5Bg5
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Congratulations 🎉, @JunminPengLab
Beautiful work from @JunminPengLab and @Yanshen73854711 in @CellCellPress Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: https://t.co/nyUA2qa4G1 Explore this amazing resource here: https://t.co/Z2bCOKSzs5
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Nature research paper: VDAC2 loss elicits tumour destruction and inflammation for cancer therapy https://t.co/fVxeL9QRTY
nature.com
Nature - VDAC2 deficiency elicits uncontrolled IFNγ-induced BAK activation and mitochondrial damage for improved cancer therapy.
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Complex water networks visualized by cryogenic electron microscopy of RNA, done by @RDasLab, @kaiming_zhang, @chiulab
https://t.co/TxSppGxUPG
nature.com
Nature - Using cryogenic electron microscopy and a modelling approach, complex water networks in a ribozyme are visualized.
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Excited to share our new paper! We mapped proteomic changes in AD models, revealing shared pathways with human AD and delayed protein turnover in amyloid plaques. Read more: https://t.co/gmXsIDbUDs
@JunminPengLab @Yanshen73854711 #proteomics #MassSpec #Proteinturnover #Alzheimers
nature.com
Nature Communications - This study maps proteomic changes in Alzheimer’s mouse models, identifying shared pathways with humans, amyloid-driven protein turnover, and proteome-transcriptome...
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Congratulations 🎉 to @LabZheng for the two back-to-back stories on UM171 molecular glue. https://t.co/JTkfBsrz9X;
https://t.co/7EEJrxZMdg
nature.com
Nature - UM171 promotes corepressor degradation by acting as a molecular glue to induce KBTBD4–HDAC1/2 interactions with the help of inositol hexakisphosphate.
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Interesting work from @TheHurleyLab
New research from @TheHurleyLab & @ASAP_Research collaborators describes a structural pathway of enzyme activation (determined via cryo-EM analysis) of phosphatidylinositol-3 kinase complexes I (PI3KC3-C1) by VPS15 in autophagy https://t.co/b5TOyivGR2
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Congratulations, Chunyi!
🚀 Thrilled to announce our latest work published in @NatureComms ! NAPTUNE: An ultra-sensitive platform using APE1 to create 5'-phosphorylated DNA, which guides PfAgo for precise nucleic acid & protein detection. 🔗 https://t.co/sE73PT79aa
#Diagnostics #PfAgo #NucleicAcids
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congratulations, Christoph.
Congrats to our newest faculty member, Christoph Gorgulla @StJudeResearch, and colleagues @UofT @InSilicoMeds, for work just out @NatureBiotech — using quantum computing to design small molecules that inhibit KRAS. #OpenAccess
https://t.co/h3LtzS8Sb1
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Transport mechanism and structural pharmacology of human urate transporter URAT1 | Cell Res https://t.co/Ovl9SqYv28
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Love you ❤️ all @BabisKalodimos @TheCHLeeLab @LabHalic @JunminPengLab @kellogg_liz @TheBlanchardLab @m_madan_babu @kriwacki @TanjaMittag @Ineschen0, those I hugged and ones that I didn't get chance to say goodbye in person. 🙁
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Goodbye @StJudeResearch. It has been five great years. Unparalleled support, collaborative environment, but most importantly awesome colleagues @StJudeStructBio. Just can't express my appreciation enough to everyone that I worked with. Thank you all!!
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We are happy to announce the public release of EMhub, a web platform designed to support the operations of a scientific facility, enabling easy management of users, instruments, bookings, and project tracking. EMhub was unveiled at the #ACA2024 last week by @delarosatrevin
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Story 1: UM171 asymmetrically reprograms dimeric CRL3-KBTBD4 to degrade CoREST via HDAC1/2 with InsP6 as a second glue. Story (2): Cancer mutations of KBTBD4 found in medulloblastoma structurally, functionally, and mechanistically mimic UM171.
biorxiv.org
Cancer mutations can create neomorphic protein-protein interactions to drive aberrant function[1][1]. As a substrate receptor of the CULLIN3-RBX1 E3 ubiquitin ligase complex, KBTBD4 is recurrently...
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Our collaboration with @WillPPK on NOX5 is out. We captured NOX5 in different activation states, and used MD simulation to explore the initiation of electron transfer. An unexpected Zn finger was also identified that is critical for function.
nature.com
Nature Communications - NADPH oxidase 5 (NOX5) is activated by Ca2+ signaling, catalyzing superoxide production by transferring electrons from intracellular NADPH to extracellular oxygen. Here the...
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Congratulations, Suzanne! @pfeffersuzanne
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