Together with Michele Pagano's lab at NYU, we are excited to share a new story on two F-box protein E3 ligases recognizing two distinct & mutually exclusive degrons encrypted in the quaternary structure of the substrate protein

Story 1: UM171 asymmetrically reprograms dimeric CRL3-KBTBD4 to degrade CoREST via HDAC1/2 with InsP6 as a second glue. Story (2): Cancer mutations of KBTBD4 found in medulloblastoma structurally, functionally, and mechanistically mimic UM171.

Together with labs of @brian_b_liau and Philip Cole and many other collaborators, we are excited to share a new molecular glue story with many surprises.

We now formally define #molecularglue after coining the term for the MoA of #auxin in 2007.

Welcome, two new postdocs Songwen and Mark joined our lab!.

Open-state structure and pore gating mechanism of the cardiac sodium channel

RT @Huigang_Shi: Finally! Many thanks to my Ph.D. supervisor Dr. Xinzheng Zhang and my labmate Ph.D. candidate Chunling Wu. Low-cooling-rat….

RT @ShabekLab: We are hiring!!! Please RT: A postdoc position is now open in our growing lab @ShabekLab (@ucdavis California) to study the….

As part of our first entry into the Twitter world, we are happy to present our first preprint!.