ZhengLab
@LabZheng
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Ning Zheng Laboratory at University of Washington
Joined August 2019
Together with Michele Pagano's lab at NYU, we are excited to share a new story on two F-box protein E3 ligases recognizing two distinct & mutually exclusive degrons encrypted in the quaternary structure of the substrate protein
biorxiv.org
The transcription factor BACH1 regulates heme homeostasis and oxidative stress responses and promotes cancer metastasis upon aberrant accumulation. Its stability is controlled by two F-box protein...
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Story 1: UM171 asymmetrically reprograms dimeric CRL3-KBTBD4 to degrade CoREST via HDAC1/2 with InsP6 as a second glue. Story (2): Cancer mutations of KBTBD4 found in medulloblastoma structurally, functionally, and mechanistically mimic UM171.
biorxiv.org
Cancer mutations can create neomorphic protein-protein interactions to drive aberrant function[1][1]. As a substrate receptor of the CULLIN3-RBX1 E3 ubiquitin ligase complex, KBTBD4 is recurrently...
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Together with labs of @brian_b_liau and Philip Cole and many other collaborators, we are excited to share a new molecular glue story with many surprises.
biorxiv.org
UM171 is a potent small molecule agonist of ex vivo human hematopoietic stem cell (HSC) self-renewal[1][1], a process that is tightly controlled by epigenetic regulation. By co-opting KBTBD4, a...
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We now formally define #molecularglue after coining the term for the MoA of #auxin in 2007.
nature.com
Nature Communications - Molecular glue has been used as a broad term describing a class of protein interaction-promoting compounds. Here, the authors outline two unifying thermodynamic features to...
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Open-state structure and pore gating mechanism of the cardiac sodium channel
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Finally! Many thanks to my Ph.D. supervisor Dr. Xinzheng Zhang and my labmate Ph.D. candidate Chunling Wu. Low-cooling-rate freezing in biomolecular cryo-electron microscopy for recovery of initial frames
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We are hiring!!! Please RT: A postdoc position is now open in our growing lab @ShabekLab (@ucdavis California) to study the structure-function of hormone signaling pathway and the ubiquitin system. #structuralbiology #postdocjobs #ubiquitin #Biochemistry #plantbiology
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As part of our first entry into the Twitter world, we are happy to present our first preprint!
Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS https://t.co/fkZ9qQ3kvu
#bioRxiv
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