Inês Chen
@Ineschen0
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Director of Scientific & Strategic Operations Department of Structural Biology St. Jude Children's Research Hospital @StJudeStructBio Opinions my own.
Joined December 2020
Congrats @DanielS20127197, Brenda and all coauthors!
Out @MolecularCell from Schulman group @StJudeResearch & @MPI_Biochem: E3 Ub ligase CRL2-KHLDC2 uses a kinetic mechanism and auto-inhibitory self-assembly to avoid targeting non-substrate proteins with degron-like sequence. https://t.co/IFlQjMJaFr
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Work from @LabHalic with @StefanCanzar now @NAR_Open. Using genome-wide approaches to dissect the pathways that lead to #heterochromatin silencing, they unveil a new mechanism — decreased transcription efficiency, in a pathway that requires CCR4–NOT. https://t.co/nRR4ybxcQS
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Very excited to see everyone next week!
We look forward to welcoming our guest speakers in person at St. Jude next Monday for the Symposium! #structuralbiology #crystallography #NMR #cryoEM #cryoET #MDSims #HybridMethods #MachineLearning #ComputationalStructuralBiology #IntegrativeStructuralBiology
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Congrats to Maximiliane Wieland @ERundlet @MikaelScience and all coauthors!
Work from @TheBlanchardLab and @WilsonLab2 combines #smFRET and #cryoEM to reveal the mechanism of action of antimicrobial peptide argyrin: ArgB binds EF-G on ribosome and inhibits conformational changes required for translocation and EF-G dissociation. https://t.co/er1HgfIqhK
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Our new manuscript on LRRK2 activation with @zhu_hanwen Francesca and Dario @ASAP @LRRK2_central. We reveal a novel LRRK2 kinase activation mechanism via spatial regulation and protein non-symmetric tetramerization (dimer of asymmetric dimers). See animation (credit @NormanLuo5)
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New work from @TheBlanchardLab and the Javitch group reveals new insights into beta-arrestin activation and interaction with GPCR, using the power of #smFRET, now out @CellCellPress, congratulations! Check out the work here: https://t.co/90hyisFrbv
cell.com
Receptor-mediated β-arrestin activation requires relief of autoinhibition mediated by the respective C-terminal tails of the β2-adrenergic receptor and β-arrestin1. These processes depend not only on...
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Congrats Anne, @BorcherdsWade and all coauthors!
Now out @NatureChemistry: work from @TanjaMittag lab in collaboration with @PappulabWashU deciphers the rules in the stickers-and-spacers model that govern phase separation by prion-like low-complexity domains. https://t.co/SSDtPnVE2t
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Congrats to @Kriwacki and @CMullighan labs!
Out in @CD_AACR: by integrating biophysics, cellular imaging and transcriptomics, Kriwacki, Mullighan & colleagues demonstrate the role of LLPS in leukemogenesis by NUP98 fusion oncoproteins and identify the specific molecular interactions involved. https://t.co/w7GQVRXZeR
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pretty cool story, using MAS ssNMR and MD sims!
Hi-res ssNMR illuminates structures of antifungal AmB “sponges” consisting of asymmetric head-to-tail homodimers staggered in a clathrate-like lattice with large void volumes similar to the size of sterols. @TarasPogorelov @nmrfam @Illinois_Alma @UWMadison
https://t.co/B8oaGwGEXj
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Whoa, the entire Uniprot... 🤯
Today with @emblebi we’re expanding the #AlphaFold Protein Structure Database to cover UniProtKB/Swiss-Prot (of @uniprot). This includes key proteins of interest that have been manually curated by experts & will more than double the database size to >800k! https://t.co/vtBGmTClG8
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And with nice News & Views on both papers by David Drew!
nature.com
Nature - Human sodium-coupled glucose transporters seen in detail.
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More sodium-solute symporters @Nature, now from Lei Chen @PKU1898: #cryoEM structure of human SGLT2 in complex with auxiliary membrane protein MAP17 and inhibitor empagliflozin (used to treat type 2 diabetes). https://t.co/gqNKqd0NcK
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From Feng lab @StanfordMed and @LabSkiniotis: #cryoEM of 2 human Na+/solute symporters — SGLT1 (Na+/glucose, apo) and SMCT1 (Na+/monocarboxylates, with substrate) — provide a trove of functional insights on these important transporters. Out in @nature
https://t.co/PvwJhhRBmW
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Amazing work, congrats!! Worth highlighting: the structure of the TDP-43 filament core is very different from those of filaments formed in vitro.
Happy to share the first publication from our group 🥳 We used cryo-EM to determine the structure of TDP-43 filaments from individuals who had ALS with FTD. Full article online @Nature 👉 https://t.co/4Ul8wWoDWm & thread below 👇
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Looking back at an exciting year: In this month’s editorial, we highlight some of our favorite research of 2021, including Covid-19 treatments, Nobel prizes, AlphaFold and more. Check it out here: https://t.co/9dUQziAtF2
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Nature is looking for an editor with expertise in biochemistry, molecular biology and/or structural biology. Check it out, it closes on Dec 15! https://t.co/wRbfGDlvSd
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An Analysis presents the results of a community evaluation of existing software for large-scale mass spectrometry-based glycopeptide data analysis. @KawaharaSRebeca @mtandersen_lab @hupo_org #glycotime OA paper: https://t.co/KU6zscVd8V
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👏 congrats!
We used #cryoEM to identify the proteins that form mammalian doublet microtubules in bovine respiratory cilia and contribute to the motility of cilia @miao_gui @jacobranderso @JosephineBotsch
https://t.co/MAg4t10Y2Y
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Join us! St. Jude is recruiting multiple research faculty at the full, associate, and assistant levels in a major expansion of our basic and translational research programs. #cancerresearch #facultyjobs @stjuderesearch
https://t.co/L6ztYatukQ
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