Aligning Science Across Parkinson’s
@ASAP_Research
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Global initiative accelerating #ParkinsonDisease research. Join us on LinkedIn and Bluesky.
Washington, D.C.
Joined June 2020
After careful consideration, ASAP will no longer be posting on this platform. We encourage you to follow us on LinkedIn: or on Bluesky:
linkedin.com
Aligning Science Across Parkinson’s | ASAP | 3,924 followers on LinkedIn. ASAP is a global research initiative accelerating the pace of discovery for #ParkinsonsDisease. | ASAP is a global research...
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GP2 is collaborating with individuals worldwide to learn more about the genetic architecture of #ParkinsonsDisease. Want to learn more? Click on the link below to view progress and explore the latest GP2 updates.
gp2.org
Global Parkinson’s Genetics Program (GP2) is an ambitious five-year program to understand the genetic architecture of Parkinson’s disease.
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@CraggASAP @PD_Progression PD is associated with the accumulation of aggregates. Team Schapira's latest work focuses on mechanisms for reducing the amount of protein aggregates found in cells.
biorxiv.org
Parkinson disease is a neurodegenerative disorder characterised by impairment of motor function, and is associated with a progressive accumulation of insoluble aggregates of misfolded alpha-synucle...
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@CraggASAP In their latest pre-print Team Hardy @PD_Progression seeks to determine the genetic risk factors associated with the progression of dementia in some LBD patients.
medrxiv.org
Up to 80% of Parkinson’s disease patients develop dementia, but time to dementia varies widely from motor symptom onset. Dementia with Lewy bodies presents with clinical features similar to Parkins...
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@CraggASAP Reactive oxygen species (ROS) and ATP energy levels impact aging and neurodegenerative disorders, such as PD. Interested in learning more about how ROS and ATP are regulated? Check out this Team Edwards preprint to learn more!
biorxiv.org
Respiratory chain dysfunction can decrease ATP and increase reactive oxygen species (ROS) levels. Despite the importance of these metabolic parameters to a wide range of cellular functions and...
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Team Cragg @craggASAP describes their new platform designed to model neuronal circuits https://www.biorxiv.org/content/10.1101/2023.10.14.562004v1?utm_source=twitter&utm_medium=twitter&utm_campaign&utm_content=ap_qtcoub909e.
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Team De Camilli examines the impact of altering PGK1, an enzyme involved in the production of ATP, on axon metabolism and dopaminergic degeneration.
biorxiv.org
Phosphoglycerate kinase 1 (PGK1), the first ATP producing glycolytic enzyme, has emerged as a therapeutic target for Parkinson’s Disease (PD), since a potential enhancer of its activity was reported...
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Team Schlossmacher & Team Biederer partnered together to map the expression of alpha-synuclein in the mouse brain, spinal cord, retina, and gut.
biorxiv.org
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide and presents pathologically with Lewy pathology and dopaminergic neuron loss. Lewy pathology contains aggregated...
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Team Biederer mapped the pathology of tau in a mouse model and utilized computational modeling to determine how LRRK2 inhibitors might impact the progression of tau pathology.
biorxiv.org
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). These mutations elevate LRRK2 kinase activity, making LRRK2 kinase inhibitors an...
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ASAP introduces 7 new #PDresearch preprints to explore this month from October!. Read the thread below for highlights. Head to the ASAP bioRxviv channel to dive deeper into the latest #PD knowledge.
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We hope to see you at the next installation of the LRRK2 series TODAY Nov. 30th at 10:00 am (PST) with Matthew LaVoie. It is not too late to register using the link below.
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Discover November's Protocol Particular's Episode "Assessing Cellular Uptake of Fluorescently-Labeled Polyamines with Mujahid Azfar, MSc", a member of Team Vangheluwe and graduate student at KU Leuven. Episode available to watch on our YouTube channel!
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Queen Mary University of London (@QMUL) is NOW HIRING for two positions!. 🟢 GP2 Training Network Administrator.🟢 GP2 Training Network Coordinator. APPLY NOW! Deadline: December 18th. See more:
gp2.org
Discover career opportunities across multiple disciplines at GP2, specializing in accelerating Parkinson’s research and innovation.
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This month we are celebrating @noatgnuhp, Rosamund Shastry, and Raja Mirujogi from Team Alessi as our November Open Science Champions. They recently published a YouTube video series providing instructions for using their newly developed mass-spec tools.
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We're thankful for our network of researchers, participating cohorts, implementing partners, and volunteers who have contributed towards accelerating discoveries in #ParkinsonsDisease 👏
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📚ASAP's Year In Review is coming soon! Which accomplishments are you most excited to read about?.
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📣 Three new #PD datasets are available on AMP PD. New sets include SN Brain Data, Untargeted Proteomics Data, and targeted Proteomics Data. Terra notebooks & workspaces are also included in this release for these new datasets. View more:
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@EliasAdriaensse @martens_sascha @LazarouLab @ThanhNguyen_TNN Team Hurley @AutophaZeke @TheHurleyLab uncovers the high-resolution structure of a protein complex involved in initiating the cell recycling process known as autophagy in one of their recent pre-prints.
biorxiv.org
The class III phosphatidylinositol (PI) 3-kinase complexes I and II (PI3KC3-C1 and -C2) are central to the initiation of macroautophagy and endosomal maturation, respectively. Through three-dimensi...
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Members of Team Hurley, @eliasadriaensse @martens_sascha @LazarouLab @ThanhNguyen_TNN identify a mechanism that regulates the detection of damaged mitochondria
biorxiv.org
Mitophagy preserves overall mitochondrial fitness by selectively targeting damaged mitochondria for degradation. The regulatory mechanisms that prevent PINK1/Parkin-dependent mitophagy and other...
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Team Desjardins discusses how mitochondrial DNA enters into the cytosol to trigger cell death in one of their recent pre-prints.
biorxiv.org
Inflammation is an age-related factor that underlies numerous human disorders. A key driver of inflammation is the release of mitochondrial DNA (mtDNA), which binds and activates cytosolic sensors....
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