Researchers developed IDR-Puncta ML, a machine learning model that predicts which intrinsically disordered protein regions can form biomolecular condensates. This resource advances understanding of condensate formation in cancer and RNA-related diseases.

The Spatial Touchstone resource provides a robust, open-source repository for the field and enables researchers to assess the quality of their own spatial transcriptomics datasets and compare results across institutions.

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@DrJasPlummer, PhD, said: “The project started because I was frustrated with the field lacking quality metrics. Other technologies have established baseline expectations using set cell lines to tell if variation is due to the sample, machine or technician.”

A collaborative project led by St. Jude has established a comprehensive framework for standardizing spatial transcriptomics. The Spatial Touchstone project integrates publicly available imaging data with newly curated datasets across six tissue types.

Using cryo-electron microscopy, researchers captured the structural changes in SV2A when drugs bind and identified a secondary binding site that can be targeted to boost drug potency.

New research reveals how anti-epilepsy drugs interact with SV2A, a protein found in nearly all neurons and the target of therapies such as levetiracetam. This breakthrough could guide the development of more effective treatments.

St. Jude scientists discovered mitoxyperilysis, a new cell death pathway triggered by inflammation and nutrient stress. This finding opens new possibilities for cancer therapies targeting damaged mitochondria and inflammatory cell death.

St. Jude researchers developed TIRTL-seq, an innovative method for comprehensive and cost-effective T-cell receptor analysis. It processes 10 million cells at 10% of previous costs, helping accelerate immunology research and improve diagnostics.

All students receive full tuition waivers and fellowships from the St. Jude Office of Data Science, so they can concentrate on their studies without financial burden. To learn more about the ABDS program or to apply before the December 1 deadline, visit:

The first year of the program is dedicated to immersive coursework, followed by a second year of hands-on work on real St. Jude biomedical research projects. With a 14 to 1 faculty-student ratio, students have access to hundreds of mentors, advisors and staff.

Biomedical research is experiencing a data revolution. The @stjudegraduate Applied Biomedical Data Sciences (ABDS) master’s program is training the next generation of scientists to turn complex data into discoveries that advance human health.

Dolores Irala, MD, Department of Cell & Molecular Biology, was featured in a symposium at @SfNtweets Neuroscience 2025, discussing advances in research. Work like hers is how St. Jude is driving progress in cures and prevention for pediatric neurologic diseases. #SfN25

“We think that this is going to be a game-changer for accelerating the high-throughput biochemical study of chromatin states and drug discovery,” said Dao. Learn more about how St. Jude researchers are using chemistry to tackle complex challenges:

Hai Dao, PhD, creates synthetic chromatin to enable rapid, high-throughput drug screening. Daniel Blair, PhD, streamlines analysis to synthesize thousands of compounds quickly. Tommaso Cupido, PhD, finds new ways to target dynamic enzymes.

Chemistry is central to drug discovery, enabling the efficient creation, analysis, and functional exploration of new molecules. At St. Jude, researchers are advancing each step to accelerate the search for new medicines.

If you are attending SfN and interested in learning more about early-career opportunities at St. Jude, visit us in Exhibit Hall B2, booth 4019, or online at https://t.co/T9mibij0SN. #SfN25

Early-career scientists from St. Jude are presenting their latest findings at the @SfNtweets Neuroscience 2025 conference in San Diego, covering topics from rare neurodevelopmental disorders to the molecular mechanisms underlying genetic mutations.

Access to specialized equipment and support empowers scientists to perform experiments at the highest caliber. This model expands opportunity, reduces barriers and drives progress toward eliminating pediatric catastrophic diseases. Learn more:

The St. Jude Shared Resources Expo highlighted 19 lab-based institutional shared resources available for researchers. By centralizing advanced technologies and expert staff, these facilities enable investigators to pursue innovative research and collaborate across disciplines.

“What really excites me about infectious disease is the medical detective work,” she said. “Thinking about our immunocompromised, oncology and transplant patients, they have unique risk factors that really play into our diagnostic approach.”