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St. Jude Research

@StJudeResearch

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St. Jude Children’s Research Hospital: a leader in research & treatment of pediatric cancer & childhood diseases. #BestHospitals #StJudeResearch #MoreInMemphis

Memphis, Tenn.
Joined November 2011
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@StJudeResearch
St. Jude Research
2 days
St. Jude and @IAEAorg partner to address global disparities in childhood cancer care. The initiative will expand access to pediatric radiotherapy in low- and middle-income countries, strengthen health systems and improve survival rates and quality of life.
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@StJudeResearch
St. Jude Research
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"AI and data science are tools that belong in everyone’s toolbox and will strengthen discoveries across disciplines,” he said. “Empowering our workforce with the skills to navigate rapidly emerging technologies is key.".
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@StJudeResearch
St. Jude Research
2 days
Renato Umeton, PhD, is driving the use of AI and data science to accelerate discoveries at St. Jude. His work bridges research, clinical care and operations to advance pediatric medicine. Discover his vision for AI’s role in biomedical breakthroughs.
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@StJudeResearch
St. Jude Research
2 days
“We found that it wasn’t ‘this or that.’ It was ‘this and that,’” said Aseem Ansari, PhD. The study shows transcription can occur via both mechanisms, but phase separation doesn’t always enhance activity—and can even reduce it.
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@StJudeResearch
St. Jude Research
2 days
“While there is a lot of debate in the literature regarding which model is correct, we noticed that these two models haven’t been compared head-to-head, which is exactly what we did in this study,” said @TanjaMittag, PhD.
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@StJudeResearch
St. Jude Research
2 days
New research reconciles two competing models of transcription organization: phase-separated droplets versus small, soluble protein complexes. Findings reveal these mechanisms are intertwined, offering nuance and caution for interpreting transcription.
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@StJudeResearch
St. Jude Research
5 days
Through multi-departmental collaboration, researchers are uncovering mechanisms and actionable targets to improve immuno-oncology approaches. The Center of Excellence for Pediatric Immuno-oncology unites experts across disciplines to accelerate discoveries from bench to bedside.
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@StJudeResearch
St. Jude Research
5 days
As Cancer Immunotherapy Month comes to a close, we reflect on the discovery-based research that is advancing how the immune system can be harnessed to target and destroy cancer cells.
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@StJudeResearch
St. Jude Research
8 days
Akshay Sharma, MBBS, MSc, said, “This is the closest physiological evidence we have that gene therapy could protect patients at risk of stroke.”.
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@StJudeResearch
St. Jude Research
8 days
Elevated blood flow speed in the brain is a key stroke risk factor for some sickle cell patients. Gene therapy normalized blood flow in three trial participants, with effects lasting 2+ years.
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@StJudeResearch
St. Jude Research
8 days
New research shows gene therapy improves brain blood flow in sickle cell disease patients, reducing stroke risk. Findings suggest patients historically excluded from trials should now be considered.
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@StJudeResearch
St. Jude Research
8 days
@CMullighan, MBBS, MD, said, "With the genomic data we are generating on every patient, we now have a much more nuanced understanding of subtypes prone to developing drug resistance or failing therapy.".
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@StJudeResearch
St. Jude Research
8 days
St. Jude researchers, along with the University Health Network, reveal that treatment outcomes in pediatric B-ALL are impacted by the stage at which B cells become leukemic. The findings could improve risk stratification and therapy design.
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@StJudeResearch
St. Jude Research
8 days
“We have over 100,000 predictions, which is over 46 million water molecules,” said Marcus Fischer, PhD. “Our results show that drug designers unknowingly avoid tightly bound waters, so actually knowing which ones to avoid could guide the process.”
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@StJudeResearch
St. Jude Research
8 days
Water molecules are critical to protein structure and function but are often overlooked in drug discovery due to unreliable data. A new tool, ColdBrew, predicts water molecule presence in protein structures, even at higher temperatures, offering insights into drug-binding sites.
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@StJudeResearch
St. Jude Research
9 days
Through the Pediatric Translational Neuroscience Initiative, McKinnon’s discoveries are being translated into therapies for ataxia-telangiectasia and other diseases. Combining molecular research with clinical expertise, they aim to restore function and improve patients' lives.
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@StJudeResearch
St. Jude Research
9 days
His lab studies proteins such as APE1 and PNKP, which are critical for DNA repair. Loss of APE1 leads to severe apoptosis during brain development, while PNKP mutations cause neuropathy and neurodegeneration. These findings offer models for understanding disease mechanisms.
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@StJudeResearch
St. Jude Research
9 days
Genomic instability drives neurological disease but is also a path to new treatments. At St. Jude, Peter McKinnon, PhD, is uncovering how instability in DNA repair leads to neurodegeneration, apoptosis and even cancer.
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@StJudeResearch
St. Jude Research
10 days
80% of patients in COG’s clinical trial had mutations where prognostic significance varied by ancestry. The results of the study, part of the St. Jude led Chromatin Collaborative, stress the need for equitable implementation of genomic biomarkers to improve pediatric cancer care.
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@StJudeResearch
St. Jude Research
10 days
Investigators at St. Jude, @CHOP_Research, @DanaFarber, and @COGorg reveal that the same gene mutations in T-cell acute lymphoblastic leukemia had different prognostic impacts depending on genetic ancestry.
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