Hurley Lab
@TheHurleyLab
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The Hurley Lab @UCBerkeley @berkeleyMCB #autophagy #StructuralBiology #CryoEM #Membranes #xraycrystallography #OpticalTweezers. Tweets by @AutophaZeke or Jim
Berkeley, CA
Joined July 2019
RT @RobertoZoncu: Structural-functional dissection of arginine sensing by CASTOR1 and its interaction with GATOR2 to regulate mTORC1 signal….
researchsquare.com
Mechanistic target of rapamycin complex 1 (mTORC1) is a nutrient-responsive master regulator of metabolism. Amino acids control the recruitment and activation of mTORC1 at the lysosome via the...
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Proud of new work from the lab by Zhicheng (Chen) Cui @Chen3dem using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/ @G__Napolitano, A. Esposito, and A. Ballabio.
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RT @mito911_: 📣New @biorxivpreprint by Leo (Wai Kit) Lam Runa Lindblom @LazarouLab @mito911_ and collaborators. Check it out!.➡️ https://t.c….
biorxiv.org
Defects in neuronal mitophagy have been linked to neurodegenerative diseases including Parkinson’s disease. However, despite the importance of mitophagy in neuronal homeostasis, the mechanistic basis...
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RT @berkeleyMCB: We're Hiring! Assistant Professor of Biochemistry, Biophysics, and Structural Biology in MCB. Learn more and apply online:….
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RT @AutophagyPapers: Reconstitution of BNIP3/NIX-mediated autophagy reveals two pathways and hierarchical flexibility of the initiation mac….
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Thought you should know, the cryo-EM structure was solved by @MinghaoChen10 and preprinted on Jun. 1, 2023 and the cryo-EM coordinates of the same complex were released on Jun. 23, 2023 .
rcsb.org
Structure of human ULK1 complex core (2:1:1 stoichiometry)
Our new preprint has been published. This is my first work from the @NodannL . We have elucidated the mechanism of ULK complex formation through in vivo and in vitro experiments based on AlphaFold-predicted structure.
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RT @miratul_neuro: **MEETING ALERT** @BiochemSoc @ASAP_Research 20th Anniversary meeting on #PINK1 mutations in #Parkinsons. Fantastic line….
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Congratulations to all of you.
📣New article by @EliasAdriaensse @ThanhNguyen_TNN @martens_sascha @LazarouLab @mito911_ on fine regulation of #mitophagy initiation by NAP1 and SINTBAD now published in @NatureSMB !.With the amazing support of @ASAP_Research @MichaelJFoxOrg .
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Watch for a tweetorial from @kevinrosem in our lab- coming soon.
Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes | PNAS
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RT @KnVelsrud: Welcome to the EMBO Workshop Autophagy across scales at Sorrento, Italy, Sept 23-27. Remember to sign up!.@WAutophagy @CanC….
meetings.embo.org
Autophagy, a cornerstone of cellular quality control, has seen remarkable breakthroughs since the discovery of Autophagy-related genes in the 1990s. Recent advancements reveal a mechanistically plaus…
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Attention new or recent grads: we are hiring for a tech position to support a new ALS drug discovery project.
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Yay us! Go Bears!.
Congratulations to the 7 @UCBerkeley scientists elected today to the American Academy of Arts and Sciences
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Lucky to see baby giant pandas wrestling on visit to Chengdu hosted by Hurley lab alumnus Shiqian Qi.
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Hurley lab #Eclipse2024 watching in Berkeley. Partial was good enough to bring lots of smiles and oohs and ahhs.
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RT @rushika_perera: Such an honor to serve as vice-chair for an incredible meeting led by @patricia_boya and @TheHurleyLab .Looking forward….
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RT @PIHanson: Excited to share the fantastic program for this year's Lysosomes & Endocytosis Gordon Conference. Great speakers, fast-moving….
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🚨Now in print!🚨Sankalp Shukla @Sankalp Shukla_ in collaboration with @PIHanson lab and @HummerLab probes the mechanistic and cellular implications of direct membrane binding by the ESCRT and ERES associated Ca2+- sensor ALG- 2 protein. Read it: @PNASNews.
pnas.org
Apoptosis linked Gene-2 (ALG-2) is a multifunctional intracellular Ca2+ sensor and the archetypal member of the penta-EF hand protein family. ALG-2...
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