
The Science of Parkinson's
@ScienceofPD
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Personal account of the Director of Research at @CureParkinsonsT - All views my own - Kiwi - Kia kaha - 侘寂
London, England
Joined January 2016
Looking forward to the @CureParkinsonsT Autumn Research Update meeting; It is FREE (virtual & in-person); Come along & learn what we are funding in #Parkinsons research (big theme for this meeting will be MAMS - multi-arm, multi-stage trial platforms) https://t.co/NJkyVCHpaW
cureparkinsons.org.uk
Our 2025 Autumn Research Update Meeting will take place once again at the renowned Royal Society of Medicine (RSM), Wimpole Street, London, on Monday 10
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Researchers present the core clinical features associated with survival in patients with Dementia with Lewy Bodies https://t.co/DYFFqcCUpx
neurology.org
Background and ObjectivesThis analysis used clinical data from prospectively followed participants meeting criteria for probable dementia with Lewy bodies (DLB) in the Mayo Clinic Alzheimer's Disease...
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New review article explores targeting metabotropic glutamate receptors for symptomatic & disease-modifying treatment in #Parkinsons
https://t.co/StVZtz46YK
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“CDC will have lost its ability to detect outbreaks & respond to them. It will no longer be able to track diseases, in America & around the globe. That includes infectious threats like flu, foodborne illnesses & Ebola, and chronic diseases & injuries." https://t.co/CbHgsxZq4A
time.com
The layoffs targeted leaders in departments related to respiratory diseases, chronic diseases and global health.
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Everything you ever wanted to know about mitochondria-associated membranes - a new review explores molecular organization, cellular functions, & their role in health + disease (#Parkinsons get a few mentions) https://t.co/kR8tA5wQBs
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Looking for a top of the line dash cam? Protect you from potential legal or financial troubles? I got you!
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Using an unbiased FACS-based genome-wide CRISPR/Cas9 knockout screen, researchers identify key genes & pathways specifically implicated in α-syn PFFs intracellular accumulation, including heparan sulfate proteoglycans biosynthesis & Golgi trafficking https://t.co/cseN0vAUjq
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Researchers present a novel lncRNA FAM151B-DT that regulates degradation of aggregation prone proteins; Silencing FAM151B-DT in vitro is sufficient to enhance tau & #Parkinsons-associated α-synuclein aggregation https://t.co/aTcqfwRA3W
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The age association aspect of #Parkinsons does not get enough attention. Now @Mitochondri_Al @DrouinOuellet @HeatherMortiboy & colleagues provide a consistent framework to enhance research reproducibility, investigating the nexus of ageing & PD https://t.co/RJ6typxIjX
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The U.S. Constitution has 4,400 words. It is the oldest and shortest written Constitution of any major government in the world. You can read and understand the entire U.S. Constitution in graphic novel form.
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Interesting: LRRK2 inhibitors for #Alzheimers? Researchers report LRRK2 deficiency mitigates amyloid β deposition-mediated pathology in a mouse model of AD (by reprogramming microglia) https://t.co/Qujxmhzi4B
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Last week Herantis Pharma @HerantisPharma presented positive topline data from their Phase 1b trial of small peptide molecule HER-096 (designed to mimic the activity of cerebral dopamine neurotrophic factor; CDNF) in people with #Parkinsons at MDS2025 https://t.co/vY3y5rv1uu
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The new tube map of London - called the "Expobiome map"
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Meta-metabolomics?!? Ok If that is what it takes Researchers identify 11 metabolites that are differentially abundant between #Parkinsons (n=50), prodromal PD (n=30) & control cases (n=50); β-glutamate⬆️in PD and prodromal PD https://t.co/9kUPbS90Tb
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"Civilization is the only example of super intelligence." Our CEO @davidpstout on @startupprojectt explaining why we're building millions of specialized models across devices — not one giant model in the cloud. A few highlights: – Why prompting loses money – 8B models matching
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Curiously, dopamine agonist-treated cases of restless leg syndrome (n = 3077) showed a significantly longer restricted mean survival time to #Parkinsons diagnosis, compared to controls
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New retrospective cohort study using Korean National Health Insurance Service data (2002 to 2019) finds restless leg syndrome is associated with an increased risk of developing #Parkinsons; N=9919 patients with RLS & 9919 matched controls https://t.co/eFYdEMbl5J
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FFS @ScienceofPD @moversand6 @morethanatremor Novo Nordisk shuts cell therapy unit amid restructuring -
reuters.com
Novo Nordisk has decided to discontinue its cell therapy research and development efforts, a spokesperson for the Danish drugmaker told Reuters on Friday.
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New research from @AkcimenFulya @sarabandres1 & colleagues (basically everyone) presents a comprehensive genetic catalog of both known & novel coding & splicing variants potentially linked to #Parkinsons etiology in 710 African cases (& 11k controls) https://t.co/0Vu4oz5s5u
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The Wire tracks every move in college sports—are you keeping up?
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Check out our new paper on the genetics of Parkinson’s disease in African and African-admixed populations, now published in Brain. https://t.co/NZGnbT11R6
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Oh look! Speaking of combos A new funding opportunity to explore rationally designed combination therapies in #Parkinsons How interesting! https://t.co/OMchyix5Jx
cureparkinsons.org.uk
Cure Parkinson’s is excited to announce that we are now accepting expressions of interest for our new combination therapy funding call. In August, Cure
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Combination therapies! #Alzheimers is doing it, why isn't #Parkinsons? Human transcriptomic & drug repurposing analyses identify letrozole & irinotecan for AD; Medical records=⬇️lower AD risk in people exposed to letrozole or irinotecan; Rescues AD models https://t.co/JAHgv5hKl3
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BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
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🎙️ Investor Spotlight: Why Calidi Biotherapeutics $CLDI Is a Company to Watch Eric Poma, PhD, CEO of @CalidiBio, breaks down the company’s innovative approach to fighting cancer using proprietary stem cell-based platforms to deliver powerful oncolytic viruses. Why It Matters
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