The Science of Parkinson's
@ScienceofPD
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Personal account of the Director of Research at @CureParkinsonsT - All views my own - Kiwi - Kia kaha - 侘寂
London, England
Joined January 2016
RT @CureParkinsonsT: We are seeking to progress research involving combination therapies as a potential method for Parkinson’s progression.….
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Told ya!. "@CureParkinsonsT will be opening a £2 million funding call in October 2025 to encourage the testing of combination therapies for #Parkinsons". Preclinical & clinical projects. DM me if you have any questions .
cureparkinsons.org.uk
As part of our research strategy, Cure Parkinson’s is seeking to progress research involving combination therapies as a potential method for targeting
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New research from @Basak94Bishal & @ErikaHolzbaur reports the identification of a Mitophagic Stress Response ("MitoSR" - mmm, catchy!) activated by mitochondrial damage in neurons & operating in parallel to canonical Pink1/Parkin-dependent mitophagy.
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LAG3 again!.Researchers develop 2 immunoglobulin-like domains "derived from α-syn receptors, the D1 domain of lymphocyte-activation gene 3 & the V domain of advanced glycation end-products (vRAGE)" that blocks cell surface binding of α-syn fibrils.
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More preclinical data supporting the repurposing of montelukast for #Parkinsons; The leukotriene receptor antagonist improved motor function &⬇️the brain uptake of [18F]GSK ("indicating resynchronization of regional microglial activity") in A53T male mice.
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Researchers report that expression of human A53T alpha-synuclein without endogenous rat alpha-synuclein fails to elicit #Parkinsons-related phenotypes in a novel humanized rat model.
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Bioinformatics analysis across GEO datasets identifies biomarkers (NDRG1, DLD, & CIRBP) & mechanisms of action associated with endoplasmic reticulum stress & ferroptosis in #Parkinsons.
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Dopamine neuron-specific conditional knockout of mitochondrial transcription factor A (TFAM) in mice=progressive motor deficits, α-synuclein accumulation, dysregulated inter-organelle communication, & neuronal loss in the substantia nigra pars compacta.
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"No correlation between pS129 α-syn & synSAA outcome, indicating that soluble pS129 α-syn in CSF & plasma does not reflect presence of synucleinopathy. Interestingly, pS129 α-syn & other α-syn forms were signif.⬆️in #Alzheimers" vs #Parkinsons & controls.
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New research from @Angelika_Za @rimonaweil & colleagues finds impaired glymphatic clearance (measured using diffusion tensor image analysis along the perivascular space) is linked to poor cognitive outcomes in #Parkinsons.
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RT @Angelika_Za: Great to see this published We found that DTI-ALPS (a proposed indirect proxy for glymphatic clea….
movementdisorders.onlinelibrary.wiley.com
Background Impaired glymphatic clearance may contribute to pathological accumulations in Parkinson's (PD), but how it interacts with other processes causing dementia remains unclear. Diffusion...
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New research from @SamuelStupp & colleagues presents a bioactive supramolecular nanostructure containing a peptide designed based on glial cell-derived neurotrophic factor (GDNF); In vitro & in vivo data support utility in cell therapy for #Parkinsons.
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Researchers report that early Locus Coeruleus noradrenergic axon loss coincides with impaired olfaction in an #Alzheimers mouse model; They also find similar results in postmortem & TSPO-PET analyses in prodromal AD patients olfactory bulb .
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New research reports that an iPad-based eye movement assessment system meets or exceeds the benchmarks set by a clinical-grade eye tracker (EyeLink 1000 Plus), supporting its use as a scalable & cost-effective tool for screening & monitoring #Parkinsons.
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New research finds that membrane packing defects are necessary for N-terminally acetylated-αSynuclein binding & that defect-rich membranes are sufficient for NTA-αSyn binding regardless of membrane charge.
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Interestingly, "PPARGC1A (PGC-1α), GPX4, NFE2L2 (NRF2), & SIRT3 decreased with increasing disease burden, while only SIRT1 expression increased, reflecting oxidative stress & mitochondrial dysregulation. Overall, the PD monocyte transcripts correlated with PD disease burden".
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Prof Stanley Appel (92 years old & still researching!) & @MethodistHosp colleagues report peripheral monocyte transcriptional signatures from 62 people with #Parkinsons; After H&Y stratification, inflam. transcripts (IL-6, IL-1β, etc) were⬆️in PD monocytes.
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Using data from 167 studies, a new systematic review of risk factors & predictors for Lewy body dementia reports factors like older age, ♂️, APOEe4, GBA, changes in cognition, mood, behavior, sleep, gait/posture, speech, parkinsonism, & smell loss.
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An exploratory mixed methods feasibility study deems a modified, low dairy ketogenic diet feasible and acceptable for people with #Parkinsons (small study, 12 people, 12 weeks; Needs to be replicated).
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