The Science of Parkinson's
@ScienceofPD
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Personal account of the Director of Research at @CureParkinsonsT - All views my own - Kiwi - Kia kaha - 侘寂
London, England
Joined January 2016
Strange study design (no placebo control?), but researchers report 6 month supplementation with short-chain fatty acids & a prebiotic modulate intestinal & peripheral immunity and provides encouraging clinical outcomes in 72 people with #Parkinsons
https://t.co/VqBUMMgfIn
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Could serum p-tau217 signal early cognitive trouble in REM sleep behavior disorder? Phosphorylated tau is a brain protein that becomes elevated when nerve cells are stressed or degenerating. Shijun Yan and colleagues describe in a new paper in Annals of Neurology how serum p
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Watch my overview of the most significant global developments in Parkinson’s disease research emerging in 2025, highlighting advances that are reshaping the landscape of diagnosis, disease modification, and future therapeutic strategies. https://t.co/SyPQDTQFij
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New research underscores the critical role of white matter integrity as a potential indicator for tracking longitudinal cognitive deterioration in #Parkinsons
https://t.co/Zoo03BuKUC
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New research reports that the intrinsic excitability & functional corticostriatal connectivity of spiny projection neurons in dyskinetic mice oscillate between levodopa-induced dyskinesia on- & off-states in a cell- & state-specific manner https://t.co/Iku6csLM7F
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New review summarizes autopsy-confirmed data on the clinical expression of Lewy body disorders & the boundaries between #Parkinsons dementia, dementia with Lewy bodies & mixed-pathology #Alzheimers, informing interpretation of emerging bio tests for aSYN https://t.co/SZfmlZyw6c
link.springer.com
Journal of Neural Transmission - Lewy body disorders (LBD) are a spectrum of neurodegenerative diseases characterized by the presence of misfolded neuronal alpha-synuclein (aSYN) pathology in the...
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Using WES data from 3,602 #Parkinsons patients 145K individuals from the @uk_biobank, researchers identify protein-truncating variants in 9 genes that were signif. more frequent in PD cases ATP5F1C, COMMD9, OPA1, RGMB, SNX13, MGST2, NMBR, RCBTB1, & JAG1) https://t.co/ak6e8IHHS1
nature.com
npj Parkinson's Disease - Whole-exome sequencing and burden analysis identify six novel candidate risk genes and expand the genetic landscape of Parkinson’s disease
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New commentary from @MichaelOkun @basbloem & @RayDorseyMD proposes a new construct called the "#Parkinsons Universe" that reframes care as a coordinated & person-centered system - positioning the person with disease as the sun https://t.co/NzleyVIIrg
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Using GWAS data from 5229 #Parkinsons patients & 5480 controls, 2610 dementia with Lewy bodies patients & 1920 controls, & 1055 REM sleep behaviour disorder patients & 3667 controls, @ZivGanOret al find no support for genetic interactions betwn APOE & SNCA https://t.co/S5haftpXn1
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Weekend reading: New review article on the characteristics & mechanisms of cognitive impairment in #Parkinsons - from @LitvanIrene & colleagues; Lots of bases covered! https://t.co/NvKltWm6kC
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"Contrary to the dominant gain-of-toxic-function hypothesis, these observations support an alternative loss-of-function framework, whereby⬆️kinase activity may be a compensatory cellular strategy to counteract the loss or alteration of the homeostatic & neurodev. functions"
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Is the #Parkinsons associated G2019S LRRK2 variant protective or pathological? New discussion explores LRRK2's kinase activity & the neurodevelopmental origins https://t.co/tp1u4Z9FCk
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ALDH2 protects against dopaminergic neuronal cell ferroptosis by enhancing the enzyme activity of PRDX6 in a mouse model of #Parkinsons Hey @MicrobiomDigest - which one of these things is not like the other? https://t.co/fcvOP2fCAd
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New research reports HDAC6 inhibition (via the HDAC6 inhibitor ACY-738 or knockdown) reduces seeded Tau & α-synuclein pathologies in primary neuron cultures & wild-type mice https://t.co/zEO4Kn4fze
jneurosci.org
A previous compound screen identified two molecules with histone deacetylase 6 (HDAC6) inhibitory activity that reduced Alzheimer’s disease (AD)-like tau inclusions in a primary rat cortical neuron...
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The liraglutide-treated patients performed ADAS-Exec better (vs placebo; 0.15; 95% CI: 0.03−0.28; unadjusted P = 0.01), but no sig diff in ADCS-ADL (−0.58; 95% CI: −3.13 to 1.97; unadjusted P = 0.65) or CDR-SoB (−0.06; 95% CI: −0.57 to 0.44; unadjusted P = 0.81) scores
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Busy week for GLP-1 agonists in #Alzheimers A Phase 2 clinical trial by @DrPaulEdison @Clive_Ballard & colleagues investigating daily Liraglutide in 204 non-diabetic mild to moderate AD patients over 52 weeks finds no diff in cerebral glucose metabolism https://t.co/HudNahdjed
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New study reports that Foslevodopa/foscarbidopa was found to be associated with significantly greater improvements in motor function & sleep vs orally administered levodopa/carbidopa in younger patients earlier within advanced #Parkinsons
https://t.co/SoUecBptLf
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Real-time monitoring of levodopa pharmacokinetics Using a spindle-shaped carbon nanotube fiber electrochemical sensor functionalized with a nanoscale molecularly imprinted polymer on single electroactive ...I also have no idea what that means! https://t.co/3caa5SD4SQ
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Quantification of cerebrospinal fluid α-synuclein seeds by endpoint dilution seed amplification assay in #Parkinsons may serve as a potential surrogate marker of Lewy body pathological burden https://t.co/qNXxMNH1jm
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Using complexes obtained through PINK1 pulldown, researchers determine the cryo-EM structures of the human Hsp90-Cdc37-PINK1 complex at 2.84 Å, Hsp90-FKBP51-PINK1 at approximately 6 Å, & Hsp90- PINK1 at 2.98 Å https://t.co/sOfA5GKNz3
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