Scott C Blanchard
@TheBlanchardLab
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Member, Endowed Chair; Department of Structural Biology, St. Jude Children's Research Hospital @StjudeResearch @StJudeStructBio @TheBlanchardLab
Memphis, TN
Joined January 2018
I am deeply honored to receive the 2025 Kazuhiko Kinosita Award in Single-Molecule Biophysics from the Biophysical Society. Our achievements build on the foundations laid by many great scientists, including all past recipients of this award. I would like to extend my sincere
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New online! Structural basis for agonist and heat activation of nociceptor TRPM3 https://t.co/0MpXxR4jm0
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Two back-to-back stories on mitosis led by my incredible postdoc @KrunoVuk at @institutrb, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @NatureComms
https://t.co/oUwguXWRUN
https://t.co/bCnHSvthbQ
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End-to-end automation of repeat-target cryo-EM structure determination in CryoSPARC https://t.co/ghOr7vMsV7
#biorxiv_biophys
biorxiv.org
Single particle cryo-EM is a valuable and growing technique for life science and drug discovery. Currently, obtaining state-of-the-art results from cryo-EM data analysis requires a human in the loop...
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Excited to share our more recent preprint, on the role of tRNA modifications in stress granule assembly and melanoma metastasis! Congratulations to Riley Hughes and thank you to all the amazing co-authors and collaborators!
biorxiv.org
Metastasis is the leading cause of cancer related deaths, however therapies specifically targeting metastasis are lacking and remain a dire therapeutic need in the clinic. Metastasis is a highly...
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Absolutely gorgeous! This is the kind of biological beauty responsible for setting the energy resistance (éR) level in your mitochondria, enabling the transformation of food into the energy that powers your energetic self. ERP: https://t.co/3wr5GFoXe2
https://t.co/vsDGw7SLwX
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Short explanation of the physics Nobel Prize 2025 In classical mechanics you can know where a particle is and its momentum at the same time. In Quantum mechanics you can't. All information is in the wavefunction. Even if a particle is trapped, part of the wavefunction.. 🧵1/7
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Absolutely true and beautifully said. The original video she mentions is from @ScottAdamsSays, but her sincerity and passion make this version far more persuasive than that master persuader. Focus on the desired outcome, not the work required, and you can move mountains.
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📢📢A new preprint from David Baker labs is here👇👇 What if a single AI model could design RNA sequences and predict protein-DNA binding better than specialized tools?@biorxivpreprint @UWproteindesign "RNA sequence design and protein–DNA specificity prediction with NA-MPNN"
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Our 2nd @J_A_C_S paper today! Using structure-guided design to create a covalent ligand targeting the FMN riboswitch. The compound is an inverse agonist linked to changes in RNA folding. Grateful for Chungen and Rob Batey’s group collaboration. 🔗
pubs.acs.org
Small molecule ligands targeting structured RNA elements hold promise for modulating RNA function, serving as chemical probes and potential therapeutics. In this study, the characterization of...
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Key DNA repair enzyme PARP1 promotes transcriptional restart after DNA damage through PARylating and stabilizing AFF1 by preventing its ubiquitylation by the E3 ligase Siah1 https://t.co/6OF7ixcVQ8
nature.com
Nature Chemical Biology - Zhu, Fu, Zhu, Li and colleagues found that the key DNA repair enzyme poly(ADP-ribose) polymerase 1 promotes transcriptional restart after DNA damage through PARylating and...
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New paper from @cjder23 @derlabunc in @scisignal Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer https://t.co/zOfK0rsyRP "almost one-third of ERK-regulated genes were also regulated by MYC in PDAC cells"
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A compelling illustration of the difference between mRNA abundance, ribosome density and protein abundance.
A cancer therapy targeting the interaction between metabolism & protein synthesis. Dietary restriction of arginine and proline depletes polyamines, which in turn causes ribosome stalling at codons with A in the third position. This shifts the balances towards cell ...
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Nature research paper: Design of facilitated dissociation enables timing of cytokine signalling https://t.co/vcf9TV4uT5
nature.com
Nature - A fresh approach to protein design that incorporates excited intermediate states enables precise control over the lifetime of protein interactions, with potential applications in...
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Excited to share the newly published work from the lab, which offers insights into the specificity and evolution of a recently discovered family of aminoacyl-tRNA deacylases.
academic.oup.com
Abstract. Aminoacyl-tRNA deacylases safeguard the accurate translation of the genetic code by hydrolyzing incorrectly synthesized aminoacyl-tRNAs. Canavany
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Unannotated translation products are widespread in model E. coli https://t.co/5KH2uNdhBU
#biorxiv_micrbio
biorxiv.org
Genomes contain orders of magnitude more open reading frames (ORFs) than known protein coding genes, and recent work suggests there may be unannotated proteins present in even the best studied...
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We sought to make proteins both potent and FAST. We used #proteindesign to design precise control over protein interaction lifetimes, enabling us to construct rapid-response circuits, biosensors, and switchable cytokines. Now published @Nature! Links to paper and tutorial below.
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New Article! Selecting aminoacyl-tRNA synthetase/tRNA pairs for efficient genetic encoding of noncanonical amino acids into proteins https://t.co/kUK4SbXqwJ
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New online! A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR https://t.co/8SKD5WRQXd
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Interested in a career in biomedical research or research information technology? Don’t miss the St. Jude Virtual Research Career, Education & Training Fair on September 25! Connect with faculty, trainees, and recruiters, and discover new opportunities to advance your career.
St. Jude is hosting the Virtual Research Career, Education & Training Fair on Thursday, September 25, from 10 AM – 3 PM CT. This free event is geared towards students, trainees and professionals in biomedical research and research information technology.
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We've released La-Proteina fully open source! New blog and source code available on our digital biology research site and github.
🧬La-Proteina🧬 The first generative model demonstrating accurate co-design of fully atomistic protein structures (sequence + side-chains + backbone) at scale, up to 800 residues, with state-of-the-art atomistic motif scaffolding performance - has just made its code open-source!
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