https://t.co/1NB9tQcBRx Huge congrats to our collaborative team for their success achieving "Parallel stopped-flow interrogation of diverse biological systems at the single-molecule scale" https://t.co/NeaKvWHyFO An advance in experimental throughput and sensitivity that

Researchers have revealed a hidden intermediate state at the center of Src kinase function. This fleeting state is vital for rapid cell migration and T-cell activation, opening new possibilities for targeting kinases.

We wrote two reviews on cell migration, published today in Nature Methods. They provides practical guidelines how to select a cell-migration assay and how to analyze cell-migration data Review 1: https://t.co/3qGrW9OACg Review 2: https://t.co/blDVq3e708

CellSAM uses an object detector, CellFinder, to detect cells and prompt the Segment Anything Model to generate segmentations with human-level performance across a range of bioimage data. https://t.co/9Nxru2Hj4z

A Method to Watch: Intrinsic protein disorder at scale https://t.co/OPxJbuD3xB

DNA nanodevice for analysis of force-activated protein extension and interactions. A tension-modulated #DNAorigami #nanosensor, compatible with bulk biochemical analysis in cell lysates, is used to assess the force-induced interaction of proteins. https://t.co/5jmdFDhENZ

Researchers use #AI and Reverse Vaccinology 2.0 on human blood samples to identify a potential new mpox target, and use the target in a vaccine that elicited mpox-neutralizing antibodies in mice. @ScienceTM https://t.co/xl05ZBCoIL

🚨Today in @NatureComms: We resolve an enduring enigma in T cell biology—how TCR binding to p/HLA triggers intracellular signaling. CryoEM in native environment reveals a 'jack-in-the-box' mechanism! Collab btw @RockefellerUniv @MSKCancerCenter @parkerici https://t.co/HJng8WvjOp

St. Jude researchers developed Combocat, a machine learning-powered platform that rapidly screens drug combinations at scale. In a proof-of-principle test, 9,045 drug pairs were screened, uncovering new synergistic therapies.

Parallelized single-molecule fluorescence and FRET experiments enable quantitative analysis of molecule function from multiple samples in a single experiment. @TheBlanchardLab https://t.co/dNUYpuFStZ

Online Now: Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria https://t.co/dQW1geDuw7

Using single-particle cryo-EM on native samples of the human parasite Toxoplasma gondii, we determined structures of four major components of the conoid, its cell-invasion machinery. This project builds on our continued collaboration with the David Sibley lab at WashU.

An RNA splicing system that excises DNA transposons from animal mRNAs | Nature

Extrusive and cohesive cohesin cooperate to repair double-strand breaks in DNA. Learn more in a new #SciencePerspective: https://t.co/DTKO1zFVpJ

New work describes our efforts to achieve CRISPR editing of the mitochondrial genome. https://t.co/L98rtFj5Yq The CRISPR toolbox has revolutionized the study of nuclear DNA, but the mitochondrial genome (mtDNA) has remained out of reach, mainly because there are no known ways

Single-cell proteomics enables discoveries! It illuminates the frontiers of biomedical research.

Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs https://t.co/DxC7r21pP8

New online! Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation https://t.co/EQm9ydzC4B

#preprint from @JunLiuLab #postdoc @guowangbiao and @YueJianUSTC @YaleMed #Vibriocholerae #flagellum https://t.co/jpxsjZhB1H

New online! CryoAtom improves model building for cryo-EM https://t.co/pzDNWQVBvd

Online Now: Recycling of ribosomes at stop codons drives the rate of translation and the transition from proliferation to RESt https://t.co/yaOQbY2L7u