This overlap highlights the importance of comprehensive genetic analysis and careful interpretation to inform diagnosis and care for individuals with motor neuron diseases, supporting more personalized clinical approaches.

Researchers identified 423 unique ultrarare genetic variants in a diverse cohort of ALS and HSP patients, revealing significant overlap in disease-linked genes previously thought to be distinct.

Watch the full video to learn more about GEMINI and the long-term vision of the program to help children around the world.

GEMINI is a program of the St. Jude Pediatric Translational Neuroscience Initiative, linking genomics and therapeutic development. This model enables rapid translation from discovery to treatment, with the goal of expanding beyond neurological diseases to reach more children.

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Many pediatric neurological diseases are rare and complex, affecting only a small number of children. GEMINI was created at St. Jude to meet this challenge by identifying genetic mutations and developing targeted therapies, advancing from discovery to clinical trial.

The Global Child Health MS Program and Global Scholars Projects at @stjudegraduate equip clinicians and administrators to address complex challenges in pediatric health through advanced research and experiential learning. Learn more:

Events such as SIOP foster global collaboration and unite experts in childhood cancer care. At SIOP, Global Scholars showcase how diverse perspective and international partnerships drive progress in research, treatment and advocacy.

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Julie Laveglia, EdD, MA, assistant dean for the Global Child Health MS Program, was at @WorldSIOP 2025 in Amsterdam connecting with students, Global Scholars and prospective applicants.

Targeting these metabolic pathways altered regulatory T cell function and enhanced anti-tumor immunity in preclinical models. This work highlights new therapeutic avenues for autoimmune, inflammatory diseases and cancer.

By generating single-cell gene expression data, St. Jude scientists discovered how metabolism regulates regulatory T cell activation during inflammation. Mitochondria and lysosome-associated pathways work together to control these immune “brakes.”

The Guide is accessible on any device and retains data even if internet connectivity is disrupted. Learn more about the ARIA Guide and access resources:

Designed for use in diverse healthcare settings, ARIA supports clinicians with practical recommendations tailored to local resources. Nearly 700 providers from over 80 countries have contributed to ARIA, ensuring its guidance reflects real-world needs.

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The ARIA Guide, developed through collaboration between St. Jude Global, @WorldSIOP and leading organizations, provides resource-adapted, evidence-based guidelines for childhood cancer care. #SIOPCongress #StJudeGlobal

The National Academy of Medicine brings together leaders to address critical issues in health, science and policy, inspiring action and informing decisions for a healthier future. Rogers and Taylor are the 13th and 14th St. Jude faculty to join the National Academies.

Rogers is recognized for discoveries in medical mycology and antifungal pharmacology. Taylor is honored for breakthroughs in neuroscience and leadership in advancing research at St. Jude.

P. David Rogers, PharmD, PhD, and J. Paul Taylor, MD, PhD, have been elected to the National Academy of Medicine, one of the highest honors in health and medicine. https://t.co/3ydPRAOctG

“We were impressed with how streamlined their process is in getting you approved for purchasing and installing the system. And it’s pretty amazing that you no longer have to pay the utility company for your electricity because the system provides all the electric power you need

Kleist’s work in the Center of Excellence for Data Driven Discovery focuses on molecular-scale events, including influenza virus proteins and the chemokine receptor system. His research is advancing strategies to combat infectious diseases and improve cell therapies.

Andrew Kleist, MD, PhD, has been named a 2025 STAT Wunderkind. The designation recognizes early-career scientists making breakthrough discoveries in health and medicine. https://t.co/d4DryqpMAB

“These structures provide a new model for how Hsp40 and Hsp70 function together and how their malfunction can lead to disease,” said Babis Kalodimos, PhD. The findings offer a foundation for therapeutic strategies targeting chaperone dysfunction.

Researchers used advanced imaging to map the complex in multiple states. The glycine/phenylalanine-rich region of Hsp40 was shown to facilitate client protein handoff to Hsp70 and regulate release, clarifying its role in disease.

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