Enrique Gabandé Rodríguez
@EnriqueGab
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Senior postdoctoral researcher at @MMittelbrunn's lab, Centro de Biología Molecular Severo Ochoa (CBMSO) @CBMSO_CSIC_UAM. @enriquegab.bsky.social
Comunidad de Madrid, España
Joined September 2009
Thrilled to share this. Big thanks to everyone involved, especially @gsotoheredero and @MMittelbrunn for the huge effort.
𝐈𝐧𝐭𝐫𝐢𝐠𝐮𝐞𝐝 𝐛𝐲 𝐭𝐡𝐞 𝐜𝐨𝐧𝐭𝐫𝐢𝐛𝐮𝐭𝐢𝐨𝐧 𝐨𝐟 𝐈𝐦𝐦𝐮𝐧𝐞 𝐂𝐞𝐥𝐥𝐬 𝐭𝐨 𝐚𝐠𝐢𝐧𝐠? Work led by @enriquegab & @gsotoheredero @CSIC identify the crosstalk between adaptive & innate cells as a target to promote healthy #aging #LONGEVITY
https://t.co/JDfHTsYdK8
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Congrats Alicia on the best poster prize in the PhD & Postdoc Annual Meeting @CBM_CSIC_UAM Very proud of you! Many more successes to come!
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As the saying goes, one man’s trash is another man’s treasure: the flow-cytometry doublets that are routinely excluded from analysis are in fact a rich source of tumor-reactive T cells. #immunology
#science
#tumor
#immunotherapy
https://t.co/Jlja2ejxDS
nature.com
Nature - Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.
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Alzheimer’s disease causes bone marrow myelopoiesis dysfunction https://t.co/vnZbZgHkIe LT-HSCs in WT femur versus skull👇
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We are looking for a candidate to apply for a postdoctoral contract in the Juan de la Cierva 2025 call, to join our lab at the @CBM_CSIC_UAM to work on the interplay between the ubiquitin pathway, DNA replication and the replication stress response.
Aprobada la convocatoria Juan de la Cierva 2025 (#JDC2025) para fomentar la incorporación de jóvenes doctores/as y completar su formación postdoctoral en centros de I+D. ▶️500 ayudas 💵60 M€ (+21,7 M€ que 2024) 📅Plazo: 25 nov-10/17 dic 2025 📰 https://t.co/lA3HGPYM8w
#FSE+
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Postdoctoral Position in "Molecular Mechanisms of Childhood Leukemia Development" at CBM, Madrid @CBM_CSIC_UAM
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What happens to our immune system with aging, reducing vaccine response? Our memory T cells undergo a dramatic shift resulting in dysregulated B cell antibody production @AllenInstitute @Nature
https://t.co/ihldk4Amyr
nature.com
Nature - This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes...
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Why simply ending animal testing isn’t the answer in biomedical research
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1. Online now in Nature, we present our effort to understand the mechanistic basis of congenital heart defects in children with Down Syndrome. An overview thread below... @Nature
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@biorxivpreprint Stem-like PD-1+TCF-1+ CD8+ T cells result from helpless priming and rely on CD4+ T-cell help to complete their cytotoxic effector differentiation https://t.co/Q20bfcG122 🇳🇱
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Estoy harta de la excusita de que “los colegios no pueden hacer nada” ante el bullying. Claro que pueden. Y si no lo hacen, son cómplices. Porque el acoso escolar no aparece de repente. Se ve, se huele y se tolera. El aula es un ecosistema donde todo se nota. Abro hilo y melón👇
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1.🧠 Excited to share our new paper in @NatureCellBio led by @Rabiarkhawaja : “Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome” https://t.co/q08j1GvZJz
nature.com
Nature Cell Biology - Khawaja et al. show sex-specific differences in neuronal-activity regulation by chaperone-mediated autophagy and that loss of chaperone-mediated autophagy leads to defective...
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BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 It started from my frustration with the depressing effect that the current publishing system has
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Coldplay - The Scientist #alternative
https://t.co/XhxBlvuujJ
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Ha muerto Sir John Gurdon con 92 años (1933-2025), premio nobel de medicina en 2012 junto a Shinya Yamanaka por desdubrir que es posible reprogramar células adultas y convertirlas en pluripotentes. En 1962 clonó ranas de células intestinales de renacuajos. https://t.co/VrZOrdAMrh
cam.ac.uk
Sir John was a visionary in the field of developmental biology, whose pioneering work on nuclear transfer in frogs addressed one of the most fundamental questions in biology: whether genetic
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Me han dicho que hoy ha fallecido John Gurdon, un tipo al que con 16 años le dijeron que no llegaría a nada. 👇
El señor d la foto es el biólogo John Gurdon. En 1949 un profesor escribió: «Creo q Gurdon quiere ser científico; si no puede aprender lo más simple d la Biología no conseguirá su objetivo y será una completa pérdida d tiempo tanto para él como para quienes le enseñamos» [Sigue]
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T cells to the rescue (again)!! Congratulations to the winners! Quite frankly I would have added S. Rudensky…
BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
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BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
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Inflammatory reprogramming of human brain endothelial cells compromises blood–brain barrier integrity in Alzheimer’s disease https://t.co/sttgtlXLsk
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Our new @Nature study reveals a proteotoxic shock as a key mechanism of T-cell exhaustion. TexPSR (proteotoxic stress response in T-cell exhaustion) is driven by increased protein synthesis + buildup of misfolded proteins, leading to T-cell dysfunction. 👉 https://t.co/154ORc2MnD
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