Emilio Lecona's Lab
@UbiSystemLab
Followers
81
Following
20
Media
17
Statuses
42
Account of the Chromatin, cancer and the ubiquitin system lab, based in the CBM. Focus on DNA replication dynamics, ubiquitin, SUMO and cancer.
CBM, CSIC-UAM - Madrid
Joined March 2024
There is still time, contact us if you are interested
We are looking for a candidate to apply for a postdoctoral contract in the Juan de la Cierva 2025 call, to join our lab at the @CBM_CSIC_UAM to work on the interplay between the ubiquitin pathway, DNA replication and the replication stress response.
0
2
0
Congrats Alicia on the best poster prize in the PhD & Postdoc Annual Meeting @CBM_CSIC_UAM Very proud of you! Many more successes to come!
0
3
16
We are looking for a candidate to apply for a postdoctoral contract in the Juan de la Cierva 2025 call, to join our lab at the @CBM_CSIC_UAM to work on the interplay between the ubiquitin pathway, DNA replication and the replication stress response.
Aprobada la convocatoria Juan de la Cierva 2025 (#JDC2025) para fomentar la incorporación de jóvenes doctores/as y completar su formación postdoctoral en centros de I+D. ▶️500 ayudas 💵60 M€ (+21,7 M€ que 2024) 📅Plazo: 25 nov-10/17 dic 2025 📰 https://t.co/lA3HGPYM8w
#FSE+
1
8
4
We are looking for a candidate to apply for a postdoctoral contract in the Juan de la Cierva 2025 call, to join our lab at the @CBM_CSIC_UAM to work on the interplay between the ubiquitin pathway, DNA replication and the replication stress response.
Aprobada la convocatoria Juan de la Cierva 2025 (#JDC2025) para fomentar la incorporación de jóvenes doctores/as y completar su formación postdoctoral en centros de I+D. ▶️500 ayudas 💵60 M€ (+21,7 M€ que 2024) 📅Plazo: 25 nov-10/17 dic 2025 📰 https://t.co/lA3HGPYM8w
#FSE+
1
8
4
Postdoctoral Position in "Molecular Mechanisms of Childhood Leukemia Development" at CBM, Madrid @CBM_CSIC_UAM
0
18
17
🎉👏🏅¡Enhorabuena a los galardonados con los Premios a Jóvenes Investigadores Fundación BBVA-@SEBBM_es! Consulta la lista de los premiados: 📰 https://t.co/0VjrSDjbfJ
1
10
23
Very proud of @rodrimartinr showing his work his awesome work.
Regulation of DNA replication and the replication stress response by ubiquitin and VCP/p97 por @rodrimartinr de @UbiSystemLab @CBM_CSIC_UAM #47congresoSEBBM
0
2
10
Another exciting research article from a member of the #RepliFate network! The @altmeyerlab identified the CNOT1-CCR4-NOT complex as a multi-level suppressor of the 53BP1-p53-p21 signaling axis. Check out their findings here: https://t.co/1uO6kmaOYM
0
3
4
Still looking! Please spread the word.
We are looking for a candidate to apply to a #MSCA Postdoctoral Fellowship in our lab in the @CBM_CSIC_UAM, working on the connections between DNA replication dynamics, replication stress and genomic instability in cáncer. Contact us if you are interested and please retweet.
0
9
2
We are looking for a candidate to apply to a #MSCA Postdoctoral Fellowship in our lab in the @CBM_CSIC_UAM, working on the connections between DNA replication dynamics, replication stress and genomic instability in cáncer. Contact us if you are interested and please retweet.
0
27
13
Muchas gracias por destacar nuestro trabajo en el @UbiSystemLab liderado por @rodrimartinr y en colaboración con @SaraRodriguezAc en el @JMendez_DNA lab.
Avance clave desde el @CBM_CSIC_UAM , donde trabajó Margarita Salas: descubren un mecanismo que regula cómo se copia el ADN y evita errores durante la replicación. #Ciencia #CBM #Replicacion #ADN
0
3
8
@Emlecona @CBM_CSIC_UAM @JMendez_DNA @CNIOStopCancer @SaraRodriguezAc @rodrimartinr Huge thanks to all people involved, @SMOA_CBM and flow cytometry facilities from @CNIOStopCancer and @CBM_CSIC_UAM.
1
5
14
So, to sum up: VCP/p97 ➡️ POLA/PRIM on chromatin ➡️ priming ➡️ basal RSR activation! This work was led by @Emlecona from @CBM_CSIC_UAM in collaboration with @JMendez_DNA from @CNIOStopCancer. Want to dive a little bit more in our work? Click this link! https://t.co/I9LPzRK6Js
1
2
6
And the activation of the RSR induced by VCPi is relevant, as the phosphorylation of CHK1 leads to an arrest in G2/M. More importantly, CHK1 activation is lost when we block the priming action of POLA/PRIM.
1
0
1
What are the consequences of more POLA/PRIM on chromatin? We observed that the inhibition of VCP/p97 also increased priming by POLA/PRIM, as observed in the EdU comet assay.
1
0
1
In fact, we showed that VCP/p97 and POLA/PRIM do interact. Interestingly, VCP/p97 inhibition could not induce the accumulation of POLA/PRIM on chromatin if origin firing is inhibited with CDC7i.
1
0
1
It struck our attention that the increased activation of the RSR induced when VCP/p97 is inhibited is mirrored by the accumulation of POLA/PRIM on chromatin. Could our two guests be working together?
1
0
1
First, we found that VCP/p97 is necessary for DNA replication and its inhibition leads to defects in fork progression and origin firing that result in the activation of the RSR.
1
0
1