Ruslan Rust
@rust_ruslan
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Asst Prof @KeckMedicineUSC @USC with interest in the brain, BBB, stem cells, AI + what can go wrong after stroke & AD. Alum @ETH_en @UZH_en Editor @ResearchHubF
Los Angeles, USA
Joined June 2019
Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer's disease | bioRxiv
biorxiv.org
The neurovascular unit is critical for brain health, and its dysfunction has been linked to Alzheimer's disease (AD). However, a cell-type-resolved understanding of how diverse vascular cells become...
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RT @jeffyfish9: If you’re a funder and you run your RFPs on @ResearchHub - we help you get. 1️⃣ Increased visibility.2️⃣ Expert matching us….
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Blazing-fast image creation – using just your voice. Try Grok Imagine.
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RT @ResearchHubF: New record on ResearchHub: Nearly 300 peer reviews completed in the past 7 days, our highest week ever. Key stats:.⏱ Avg….
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RT @Pluchinolab: Mitochondria structurally remodel near synapses to fuel the sustained energy demands of plasticity
biorxiv.org
The brain is a metabolically demanding organ as it orchestrates and stabilizes neuronal network activity through plasticity. This mechanism imposes enormous and prolonged energetic demands at...
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The Chan Zuckerberg Initiative has released precomputed TranscriptFormer embeddings for the entire CZ CELL×GENE Census covering 106M human cells and 42M mouse cells, spanning 1000+ cell types in healthy tissue and across hundreds of disease contexts:
cellxgene.cziscience.com
Find, download, and visually explore curated and standardized single cell datasets.
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Children with rare genetic diseases get CRISPR Cures center | Nature Biotechnology
nature.com
Nature Biotechnology - Children with rare genetic diseases get CRISPR Cures center
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RT @satyanadella: It’s been a few weeks since we brought GPT-5 to Microsoft 365 Copilot, and it’s quickly become part of my everyday workfl….
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RT @tangming2005: (Harvard STAT115): Introduction to Bioinformatics and Computational Biology by Shirley Liu. https….
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Interesting thoughts here: The future of reviews: Will LLMs render them obsolete?: EMBO reports:
embopress.org
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Big thank you @BioProtocol @paulkhls @RafaDeSci to select our work for the gov proposal and share it with the community!.
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Link to original pre-registration:.
researchhub.com
Effects of psilocybin and related compounds on neuroprotection...
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Why does this matter? . Stroke affects 1 in 4 people and leaves millions with permanent deficits, yet there are no neuroprotective therapies. Psilocybin is already in trials for depression and PTSD. If effective here, it could point to a new direction for stroke therapy.
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What we propose to do:.1️⃣ Screen psychedelics in mouse stroke brain slices 2️⃣ Identify which cell types and pathways are involved.3️⃣ Validate lead compounds in ischemic human brain tissue.
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But there are still tons of open questions e.g.:.❓Does it translate to humans?.❓Which brain cells are protected?.❓What is the mechanism? .❓Are there psilocybin related compounds that might be even more effective?.
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Psilocybin has shown neuroprotective effects in stroke models e.g. reducing inflammation, preserving tissue, and improving function in rodents e.g. here:
bmcneurosci.biomedcentral.com
Background Psilocybin is a psychedelic 5HT2A receptor agonist found in “magic mushrooms”. Recent studies have indicated that 5HT2A agonists, such as dimethyltryptamine, given before middle cerebral...
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The main question is: Can psilocybin protect the human brain after stroke?.
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Check out this gov proposal by @BioProtocol to support our reseach on psilocybin and stroke on @ResearchHub. This is amazing! Let me give everyone a bit of context on our proposed work 👇.
New Gov Proposal: Use $RSC from the Bio treasury to fund @ResearchHub study on Psilocybin’s Neuroprotective Role in Stroke. • Scientific Focus: Psilocybin’s modulation of neuroprotective pathways in stroke-affected human brain tissue. • Strategic Impact: Enhance dealflow
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RT @RafaDeSci: @BioProtocol governance proposal live: deploying $RSC from treasury to support @rust_ruslan latest project on @ResearchHub.….
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RT @EricTopol: Adherence to a Mediterranean diet linked to reduced dementia-related metabolites, many of which showed causal relationships….
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ApoE4 disrupts intracellular trafficking and iron homeostasis in a reproducible iPSC-based model of human brain endothelial cells: Stem Cell Reports
cell.com
Bell and colleagues develop a new protocol to differentiate brain endothelial cells from iPSC to investigate the regulation of intracellular transport across the blood-brain barrier. They find that...
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