Zihai Li, MD, PhD
@Zihai
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Founding Director, Pelotonia Institute for Immuno-Oncology (@OhioStatePIIO) • Deputy Director of @OSUCCC_James for Translational Research • Views My Own
Columbus, OH
Joined July 2009
Our new @Nature study reveals a proteotoxic shock as a key mechanism of T-cell exhaustion. TexPSR (proteotoxic stress response in T-cell exhaustion) is driven by increased protein synthesis + buildup of misfolded proteins, leading to T-cell dysfunction. 👉 https://t.co/154ORc2MnD
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In vivo chimeric antigen receptor (CAR)-T cell therapy !
nature.com
Nature Reviews Drug Discovery - In vivo chimeric antigen receptor (CAR)-T cell engineering uses targeted delivery systems to generate CAR-T cells directly in patients, bypassing ex vivo...
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Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! https://t.co/J5HekY1Pc0
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Yes I have been trying to tell one story for the last 30 years. #Immunotherapy
Every single cancer researcher I know refers to the latest exciting findings in their lab as a “story”. I guess all of us scientists are storytellers at heart.
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Love it! Tumor Tregs may be more vulnerable.
nature.com
Nature Immunology - Rudensky and colleagues demonstrate a context-dependent differential requirement for Foxp3 for Treg cell transcriptional and functional programs.
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Many thanks to @NatRevImmunol and Dr. Alexandra Flemming for highlighting our recent work on #TexPSR in driving T cell exhaustion. @OhioStatePIIO
https://t.co/VwCgs5DXZc
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- Immigrates to US at 15 dirt-poor - Undergrad at Hudson Valley Community College & SUNY Albany - PhD at University of Illinois Urbana-Champaign - NSF postdoc at Harvard ... Nobel Prize! A testament to the US education and research system and the US would be poorer without it!
This year’s chemistry laureate Omar Yaghi was born in Amman, Jordan, in 1965 to parents who were refugees from Palestine. When we spoke to him he shared his story: “I grew up in a very humble home, we were a dozen of us in one room, sharing it with the cattle that we used to
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“Positive selection during spermatogenesis drives a 2–3-fold increased risk of known disease-causing mutations, which results in 3–5% of sperm from middle-aged to older individuals with a pathogenic mutation across the exome” https://t.co/tIsKc79Tnz
nature.com
Nature - A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.
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New #JITC article: T cell subsets of urine-derived lymphocytes (UDLs) serve as an indicator of TILs and reflect immunological sex differences in bladder cancer https://t.co/q54ekHXQBr
@Zihai @CarsonLabOSU @djmcconkey
@OhioStatePIIO
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Sexual selection drives sex difference in adult life expectancy across mammals and birds
science.org
Sexual size dimorphism and mating system contribute to male and female life-span differences across wild and zoo populations.
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Dr. Mary Brunkown, one of the three newly minted #Nobel_laureates did not chase funding, # of pubs or fame, but made a landmark discovery of Foxp3 (a master regulator of regulatory T cells in governing immune system’s self tolerance).
nature.com
Nature Genetics - Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
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Wonderful and comprehensive review on antibody therapeutics by Chan et al. @Genentech in @NatRevImmunol. A must-read for anyone in immunology and oncology. 🔗 https://t.co/ikbZ9bc85w
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Nice review here in @NatRevClinOncol The tumour microenvironment in #PancreaticCancer — new clinical challenges, but more opportunities https://t.co/xClZIjZHfe By Lei Zheng @mayscancer @KimmelCancerCtr
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The skyline glows scarlet and gray. 🌟 Honored to stand with our @OhioState and @OSUCCC_James teams as the Block O lights the way. #BuckeyeSpirit
The Buckeye spirit lit up the sky tonight as The James team joined our @OhioState health care colleagues to celebrate the lighting of the Block O at the top of the new University Hospital tower.
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#ScienceSaturday ❓ Why do T cells sometimes fail to fight cancer? ➡️ A new study in Nature shows that when T cells are exposed to cancer or long-term infections, they can enter a state called exhaustion, where they lose their ability to eliminate harmful cells. ➡️ The
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What an amazing talk by @szusmani on how we cure what used to be an incurable cancer - multiple #myeloma. #NYOF @CAHON_hemonc
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This is the work of @SizunJ - what a talent!! I am just one of his many fans.
🚨New publication featuring #PIIO Founding Director @zihai & PIIO Center for #AI & #Bioinformatics in #ImmunoOncology (CATION) Leader, @QinMaBMBL, maps a multi-scale #SingleCell & #spatial atlas of CRS, uncovering #immune–epithelial interactions & cell fate links to #polyp
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