Zihai Li, MD, PhD
@Zihai
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Founding Director, Pelotonia Institute for Immuno-Oncology (@OhioStatePIIO) • Deputy Director of @OSUCCC_James for Translational Research • Views My Own
Columbus, OH
Joined July 2009
Our new @Nature study reveals a proteotoxic shock as a key mechanism of T-cell exhaustion. TexPSR (proteotoxic stress response in T-cell exhaustion) is driven by increased protein synthesis + buildup of misfolded proteins, leading to T-cell dysfunction. 👉 https://t.co/154ORc2MnD
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The difference in glycan compositions between cancer and normal tissues is known. How to target this difference therapeutically has been elusive. This study provides an asnwer by velcro-like density-dependent targeting of tumor-associated carbohydrates.
cell.com
Targeting tumor-associated carbohydrate antigens, the most abundant and widespread cancer antigens known, via “velcro-like” binding of lectins allows immunosuppression-resistant pan-cancer killing...
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What a statement!! #GoBucks!!
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NIH has launched the Replication Prize to identify scientific areas in need of #replication studies and discovery of new strategies to integrate replication into biomedical research. Learn more: https://t.co/srLTX9T65q
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🔥 Excited to spotlight new faculty member Dr. Maria Velegraki at #ASH25! Her work on Garp/LRRC32 reflects a powerful OSU collaboration across multiple departments. Catch her oral presentation: 🩸 Sat, Dec 6 • 2:15 PM — Abstract 10344 @ASH_hematology @OhioStatePIIO @osu_pharmacy
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A celebration fit for a Shoe 🚲🙆🙌 The @pelotonia community took center stage at today’s @OhioStateFB game, where the crowd showed its appreciation for another year of amazing support, with more than $29 million raised for cancer research @OhioState.
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What a loss to our field! Dr. Chu’s legacy in medical oncology lives on! A reminder of so much work ahead of us.
cancerletter.com
Edward Chu was an expert in pharmacology whose research improved therapies for colorectal cancer, leading to the identification of new treatment targets and driving scientific advances in the field. ...
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Last Friday, new NCI Director Dr. Anthony Letai met with staff for the first time. His message: • Fund gold-standard cancer research. • Inspire the next generation of scientists. • Tell our story so the public knows what their research investment makes possible. A hopeful
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Excited to share our study @CellCellPress introducing a novel class of macrophage-targeted immunocytokines (MiTEs) that engage myeloid, T and NK cells to boost anti-tumor immunity in solid tumors. Led by @MVLocquenghien, @PascaleZwicky & @CuriousKX (1/16) https://t.co/2z69HAdAEs
cell.com
MiTEs are myeloid-targeted immunocytokine prodrugs that block TREM2+ tumor-associated macrophages while activating cytotoxic lymphocytes via TME-specific IL-2 activity, eliciting strong anti-tumor...
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Engineering T cells (CAR-T) has had marked benefits for cancer and autoimmune disease. But doing that inside the patient's body (in vivo) would make that far more practical and less expensive. https://t.co/7d0LS1qrKa
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Congrats to the entire Pelotonia community for another record-breaking year of support, with more than $29 million raised for cancer research at The James.
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Guidelines for T cell nomenclature: evolving complexity with simple principles.
nature.com
Nature Reviews Immunology - This Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to...
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A groundbreaking paper by @younis_sh1 et al. @stanfordimmuno provides an answer to the long-standing question about how EBV infections are linked to lupus. A short thread to explain the key findings. (1/) https://t.co/dUpz19IjEv
science.org
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
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Enjoyed seeing Drs. Mehnert @JaniceM10, @LesinskiLab and @Zihai Li at this year annual @sitcancer meeting in DC. @WinshipAtEmory @NyuMed @OhioStatePIIO
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One case (n=1) revealed two key scientific facts: 1. direct role of β-HPV in causing skin cancer; 2. Protective roles of T lymphocytes against the virus (and the cancer).
nejm.org
Cutaneous squamous-cell carcinoma (SCC) is primarily caused by oncogenesis mediated by ultraviolet radiation, and β-human papillomavirus (β-HPV) is believed to be a mere facilitator that is dispens...
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Harvard chemist and molecular biologist David Liu invented gene editing tools that can correct and rewrite defective genes. His research could one day help hundreds of millions of people with genetic diseases, including sickle cell and muscular dystrophy. https://t.co/YgmqXkMouW
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