Costa Lab
@CostaLabCrick
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Biochemists & cryo-EM scientists studying chromosome replication @TheCrick
The Francis Crick Institute
Joined October 2022
I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication. 8 years of funding at the Crick Institute. Looking for a postdoc in molecular mechanism, cryo-EM and in situ structure?. Contact me now! 3 postdoc positions advertised soon.
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How does ATP hydrolysis by MCM enable replicative helicase loading onto DNA? . Find the answer in our latest article.. Congratulations to Agata Butryn, who spearheaded the entire project, Contributions from @GreiweJulia in the early days. 🎉❄️🔬🧬.
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Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳 . Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors!
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RT @BleichertLab: Our study on how the human MCM2-7 helicase is loaded onto replication origins 🧬 is now online @Nature! 🎉. Our findings re….
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RT @groth_anja: Great kickoff for the EMBO EMBL Replication symposium with amazing structural and functional insights into initiation, elon….
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RT @EMBLEvents: ⏰ Deadline approaching for #EESReplication ⏰. Submit your abstract by 13 August and find out about the latest breakthroughs….
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RT @TheCrick: Congratulations to group leaders Snezhka Oliferenko and Alessandro Costa (@CostaLabCrick) on being elected as members of @EMB….
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RT @TDDeego: Abstract and early bird deadline for the 2024 UK DNA Replication Meeting is this week. Don't miss out - its going to be a fant….
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How does Mcm10 activate an origin of replication? . Find the answer in our paper published today in @NatureSMB. Congratulations to Sarah Henrikus & our fantastic lab! 🥳🎉. Great collaboration with Marta, Allie and John from @DiffleyLab @TheCrick
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RT @IvanAhelLab: TWO postdoc positions available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for som….
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Human origin licensing reconstituted with purified proteins. Great collaboration with Florian Weissmann & John @DiffleyLab. A cryo-EM tour de force from our @GreiweJulia.
MCM Double Hexamer Loading Visualised with Human Proteins #bioRxiv.
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RT @TCR_Miller: I am happy to announce that we've recently posted our new manuscript, titled: ‘Cell Cycle Regulation has Shaped Budding Yea….
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RT @Jacob_Lewis90: 🌟 Big News! 🌟 the Lewis lab is open for business @MolHorizons. A new chapter of discovery and learning awaits. Thrilled….
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Our study on the cover of Molecular Cell 🥳. Thanks @AgaGambus and @GS_Lab_Bham for a great collaboration. Structure by Milos Cvetkovic❄️, @PaoloPassaretti🧬, Agata Butryn👩🔬. Artwork by @petermindek and the team.
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DONSON paper out! Congratulations Milos Cvetkovic and @PaoloPassaretti! Great collaboration with @AgaGambus's group. Thanks @GS_Lab_Bham for contributing. The structural mechanism of dimeric DONSON in replicative helicase activation: @MolecularCell
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RT @FASEBorg: The deadline for abstract submissions has been extended to this Sunday (5/21). Share cutting-edge research on RNA and DNA hel….
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Interested in Structure, Mechanism and Chromosome Biology?. Then you should join our lab at the Crick as a PhD student! . Applications close on 22 March 2023. You might get a hat like Julia's, who successfully defended her thesis last week! 🥳❄️🔬🧬
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Congratulations to our PhD student Julia Greiwe for receiving the Crick Science Achievement Award. As part of the celebrations, Julia gave a great talk at the Crick Autumn Science Meeting last week. She described the mechanisms MCM helicase loading and phosphorylation by DDK.
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