Grant Stewart
@GS_Lab_Bham
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The Stewart lab has a long-standing interest in studying rare human diseases associated with defective DNA repair and/or abnormal DNA replication.
Birmingham, England
Joined March 2020
Proud to present our work identifying a role for DIAPH1 and gamma-actin in regulating DSB repair and how defects in this pathway give rise to human disease. Big thanks to everyone involved, especially Beth Woodward, Sudipta Lahiri and Anoop Chauhan.
nature.com
Nature Communications - DNA double strand break repair pathways ensure genome stability and prevent disease. Here the authors show that the actin nucleating factor DIAPH1 and γ-actin promote...
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Great paper by the Vaziri lab about the role of RNF25 regulating the DDR independently of its E3 ligase activity!.
nature.com
Nature Communications - DNA replication stress is a driver of genome instability. Here, the authors identify a role of the E3 ligase RNF25 in promoting replication stress tolerance....
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RT @altmeyerlab: New work from the lab: Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling @CellReports. Congratul….
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RT @Zhang_Suyang: A transcription balance required for genome stability 🧬⚖️. Our work on RNA Pol II transcription speed control by the DNA….
nature.com
Nature Structural & Molecular Biology - Using cryo-electron microscopy and biochemistry, Zhang et al. reveal that the DNA helicase RECQL5 and the transcription-coupled DNA repair complex...
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RT @PgGarcialab: Delighted to announce that our paper showing the generation of iPSc from a MDS patient & how CEBPA drives disease progress….
nature.com
Nature Communications - In Myeloiddysplastic syndromes, CEBPA mutations are linked to disease progression and AML. Here, the authors use somatic reprogramming and genome editing to generate...
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RT @MolecularCell: Online Now: The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in hu….
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RT @MolecularCell: Online Now: The DNA replication checkpoint limits Okazaki fragment accumulation to protect and restart stalled forks htt….
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RT @nussenza: Cytarabine has been the mainstay for AML treatment. This chemotherapy can lead to problems with movement and balance. Here we….
nature.com
Nature - Certain antimetabolites used to treat cancer are more neurotoxic than others, and it is now shown that this is due to their greater tendency to generate DNA double-stranded breaks, whereas...
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RT @DrAndyBlackford: We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response me….
candidate.hr-manager.net
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Awesome paper from @SPJacksonGroup and @FrogWalterLab about USP37 and TRAIP regulating the replication response to topoisomerase inhibitors. Glad to be a part of it.
nature.com
Nature Communications - The replicative helicase CMG is targeted for removal or proteolysis by the E3 ubiquitin ligase TRAIP. This study describes how the de-ubiquitylating enzyme USP37 protects...
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RT @IvanAhelLab: Our new paper describing the RNF114 protein as a reader of dual hydrid modification composed of ADP-ribose and ubiquitin (….
biorxiv.org
Crosstalk between the post-translational modification processes ubiquitination and ADP-ribosylation occurs in DNA-damage and immune-responses, in addition the physical linkage of ADP-ribose and...
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Great collaborative study just out in Nature Communications about RNF168 regulation by PIN1.
nature.com
Nature Communications - The ubiquitin ligase, RNF168, promotes DNA break repair but must be regulated to prevent run-away ubiquitin signaling. Here, the authors identify a three-step...
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RT @CortesLab: Finally out! Congrats! @AndHR11 @SJimenoGonzalez @pmmargar @JoseT86910859 J. Lieberman and G. Millán.Hope we contribute to t….
cell.com
Herrero-Ruiz et al. analyze the function of DNA topoisomerase II in transcriptional regulation. The results reveal that TOP2A activity favors promoter-proximal pausing of RNA polymerase II and...
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Whilst it is not related to DNA repair or replication, an interesting study I was peripherally involved in is out now @JExpMed. Dominant mutations in ITPR3 cause combined immunodeficiency in humans. Congrats to Alexandra Kreins, the lead PI of this study.
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RT @RebeccaMJones4: PhD position available in the Jones lab! @MIBTP_BBSRC programme. Understanding how DNA replicat….
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RT @pedroorteg: 🧬 I'm happy to announce that our latest study, "ATR safeguards replication forks against APOBEC3B-induced toxic PARP1 trapp….
biorxiv.org
ATR is the master safeguard of genomic integrity during DNA replication. Acute inhibition of ATR with ATR inhibitor (ATRi) triggers a surge in origin firing, leading to increased levels of single-s...
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RT @luijsterburglab: New paper with @KokicGoran and @SvejstrupLab in Cell Press! We show that STK19 facilitates the clearance of lesion-sta….
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RT @CellReports: SRSF2 safeguards efficient transcription of DNA damage and repair genes
cell.com
Wagner et al. report that SRSF2 deficiency causes DNA damage and cell-cycle arrest due to inefficient transcriptional activation of bi-directional DNA replication and repair genes. Heterozygous SRSF2...
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