The Nogales Lab
@NogalesLab
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The Nogales Lab at UC Berkeley. #CryoEM #Transcription #Microtubules #ChromatinModification #Telomerase Twitter account managed by lab members.
Berkeley, CA
Joined January 2019
A unique honor to become a Foreign Member of the @RoyalSociety, together with my @UCberkeley colleague Stuart Russell and old friends like @Briggsgroup, @AsifaAkhtar1, Patrick Cramer @mpgpresident or @REMLehmann. Learning about great science and science history was a real treat.
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Very grateful to the Menéndez Pelayo International University @UIMP for awarding me an honorary doctorate last Tuesday, July 8th, in the incomparable setting of the Magdalena Palace (Santander). On Monday I enjoyed a conversation with those interested in my career and science.
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Our work, co-led by @AlfredoFlorez and @NicholasLue, is finally out in @NatureSMB. Shout out to coauthors P.Grob, B. Kaeser, J.Fang, and Susanne Kassube for their contributions, and thanks to the reviewers for their suggestions that led to the final work.
nature.com
Nature Structural & Molecular Biology - Florez Ariza and Lue et al. use cryo-electron microscopy to investigate how the RECQL5 helicase regulates transcription. Their structural findings...
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So proud of the smashing success of the International Course in Biophysics co-organized with my @berkeleyMCB colleague Carlos Bustamante @BustamanteLab and University of Salamanca @usal .Course ends with a Keynote from Nobel Laureate Richard Henderson🥇.
biophysal.org
First Summer International Advanced Biophysics and Structural Biology Course. Eva Nogales - Carlos Bustamante.
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Like a dream, my name next to that of @IsabelLAllende, and to be recognized my Universidad Internacional Menéndez Pelayo @UIMP. Soon after, Irene Vallejo @irenevalmore will receive the same honor. I feel proud to be linked to these truly inspiring, talented women! Thank you UIMP!
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RT @CNB_CSIC: 👏👏Nuestra enhorabuena a la biofísica Eva Nogales @NogalesLab, cátedra JAE-Chair en el #CNB_CSIC por este merecido reconocimie….
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RT @UAM_Biblioteca: Evangelina Nogales, doctora Honoris Causa, en la #BibliotecadeCienciasUAM @CienciasUAM https:/….
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Deeply touched and honored by the Universidad Autónoma de Madrid, my alma mater, (@UAM_Madrid) making me Doctor Honoris Causa. Thank you to the Department of Physical Chemistry for nominating me for this recognition. It was a memorable day for me and my family👩🎓
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Yesterday I had the pleasure to visit the Institute for Material Science in Madrid (@ICMM_com). Thank you to Dr. Pedro Serana for his invitation to talk about cryo-EM and our latest microtubule studies 🧩🔬🧬
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RT @AytoColmenar: 🎖️🔝 Evangelina Nogales es catedrática e investigadora y fue nombrada hija predilecta de #ColmenarViejo por sus enormes lo….
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Que día tan emocionante volver a mi colegio en Colmenar Viejo y recibir el calor de sus profesores y sus alumnos. Gracias por darle mi nombre a vuestra biblioteca! 🥰.
📚👩🔬 La reconocida científica colmenareña Evangelina Nogales inaugura la nueva biblioteca del que fue su colegio, el CPB Soledad Sainz. 🏫🤗 Los alumnos le dieron regalos e hicieron preguntas a Eva en una jornada increíblemente emotiva. ➕👇
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I spent a wonderful day in the Universidad de Córdoba at an interactive breakfast with faculty and students and giving a science presentation. Lovely to meet its Chancellor, Manuel Torralbo, and my friend and past collaborator Prof. Tina Domínguez-Martín.
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Excited to have participated in the Third Symposium of Physical Chemistry in the Universidad Autónoma de Madrid last week and honored that the Prizes for best student talk and best posters carried my name 🥰☺️
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It was an absolute pleasure to visit the IBiS, to meet its scientists, interact with its students, and visit beautiful Sevilla 🥰.
🟠SCIENCE |. Thank you very much to Prof. Eva Nogales for sharing her outstanding and inspiring science with us. It was an honor to host her at IBiS!
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This week our lab had a double celebration: 1) Eva’s election into the Royal Society and 2) Zhenlin’s new job in Southern University of Science and Technology, Shenzhen, China @SUSTechSZ. He will be missed but we wish him success and joy in his independent career!
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Check out our review article on the structural and functional studies of retrotransposon proteins by @AkankshaThawani together with @CollinsRNPLab.
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A huge shoutout to our former grad student @SusanneKassube (now PI) for leading our lab’s original study back in 2013 and setting the stage for this work. If you’re interested, check out our preprint for more details and stay tuned for the full paper! 7/7.
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Beyond a role in slowing down Pol II elongation, RECQL5 is known to decrease transcription stress. We propose that RECQL5 may help restart transcription from stalled Pol II by allosterically modulating Pol II’s translocation state. 6/7
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Nucleotide binding (AMPPNP or ADP) causes the RECQL5 helicase domain to undergo a conformational change, pulling on the DNA to induce Pol II to shift to a post-translocation state. Meanwhile, the IRI module seems to serve as a stable anchor for RECQL5 binding. 5/7
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