Ivan Ahel Lab
@IvanAhelLab
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Joined November 2017
The application deadline has been extended for a postdoc position in our lab until August 22. Please enquire/apply if you are interested in ADP-ribosylation, ubiquitination, genome stability or immunity.
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A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!.
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RT @YugengZ: Really thrilled to see our paper out now in @NAR_Open: a new transcriptional repressor, RptR, that regulates type I restrictio….
academic.oup.com
Abstract. Bacteria encode a panoply of defence systems to overcome phage infection. In recent years, over 100 defence systems have been identified, with th
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We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required.
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Our new paper describing the RNF114 protein as a reader of dual hydrid modification composed of ADP-ribose and ubiquitin (ADPr-Ub) we discovered a few years ago (collaboration with the lab of Gerbrand van der Heden van Noort).
biorxiv.org
Crosstalk between the post-translational modification processes ubiquitination and ADP-ribosylation occurs in DNA-damage and immune-responses, in addition the physical linkage of ADP-ribose and...
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A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
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RT @SamantLab: Call me a #ubiquitin geek, but this is genuinely one of the most exciting findings in recent years. Only came across Ub—ADPr….
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RT @dannybejan: I'm excited to share the final version of this story published in @embojournal Check it out!.
embopress.org
imageimageCertain E3 ligases have been found to ubiquitylate hydroxyl groups on free NAD+ and ADP-ribose in vitro, but the in vivo occurrence of this dual post-translational modification has remained...
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Our discovery of reversing enzymes for RNA ADP-ribosylation reveals a possible defence protein module against toxic attack.
pubmed.ncbi.nlm.nih.gov
Nucleic acid ADP-ribosylation and its associated enzymes involved in catalysis and hydrolysis are widespread among all kingdoms of life. Yet, its roles in mammalian and bacterial physiology including...
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Potential PhD students interested to work in our laboratory are welcome to apply through the ILESLA programme.
Two weeks to go until the application deadline for ILESLA. If you or anyone you know would benefit from full funding to carry out a PhD in Life and/or Environmental Science please visit/refer to their website where you can see open day videos and guidance.
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RT @ConstantinouL: We are pleased to inform you that the meeting “From Genome Instability to Cancer: A tribute to Angelos Constantinou” tha….
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Our laboratory is looking for a postdoc with expertise in protein biochemistry and structural biology to work on novel pathways regulated by ADP-ribosylation of nucleic acids. Please RT.
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Our new paper in collaboration with Luca Palazzo laboratory:.
Our findings indicate that this synthetic lethal interaction is notably strengthened when paired with alkylating genotoxins. (3).
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RT @MSuskiewicz: Our team in Orléans (France) is looking for a new postdoc, to work closely with a research associate, Ibtissam Talhaoui, o….
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Our new paper describing how tyrosine-linked ADP-ribosylation signalling is reversed. Big thanks to our collaborators @JgmRack, @LeidenADPr and @Lab_Matic.
jbc.org
ADP-ribosylation is an ancient posttranslational modification with exceptional versatility in terms of breadth of modification targets including at least seven different amino acid side chains,...
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RT @JgmRack: Here is the first paper out of my lab 🥳.A deep dive into a new class of macrodomains specific to bacterial and fungal pathogen….
jbc.org
Dynamic ADP-ribosylation signaling is a crucial pathway that controls fundamental cellular processes, in particular, the response to cellular stresses such as DNA damage, reactive oxygen species, and...
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If you are interested in the regulation of interplay between ADP-ribosylation and lipoylation, check our collaborative paper. Congratulations to all authors, especially to our former postdoc Johannes for his first paper as an independent group leader!.
jbc.org
Dynamic ADP-ribosylation signaling is a crucial pathway that controls fundamental cellular processes, in particular, the response to cellular stresses such as DNA damage, reactive oxygen species, and...
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RT @Dunn_School: New job opportunity 📢. Associate professor, immunity/inflammation/infection (defined broadly) especially welcome . Come a….
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Our new paper demonstrating reversible ubiquitylation of DNA and RNA:.
embopress.org
imageimageNucleic acids are a novel type of ubiquitylation substrate. Nucleic acids are ubiquitylated by DELTEX ubiquitin E3 ligase DTX3L, targeting the 3′-terminal adenosine nucleotides at their 3′...
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