Jacob Lewis 🧬 📷
@Jacob_Lewis90
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Group leader @MolHorizons @UOW studying all things DNA replication | DECRA fellow & NHMRC Investigator
Wollongong, Australia
Joined April 2019
How is the separation of two DNA strands nucleated after the initiation of chromosome replication in eukaryotes? We were curious too... You can read about what we found here @Nature – a sneak peak👇 https://t.co/tu5B3DHtDC 1/4
nature.com
Nature - Cryo-electron microscopy structures of the sequential assembly of the CMG replicative helicase on a chromatinized origin of replication provide insights into the mechanism through which...
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🚀 Exciting opportunity! We’re looking for a Postdoc to join the Lewis & Spenkelink Lab @MolHorizons 🎓 Love structural biology, biochemistry & mitochondrial DNA replication? Come work with us! Start: July 2025 | Location: Coastal Wollongong 🌊 Apply:
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How do mitochondria replicate their DNA? 🧬 Excited to share that our lab, based at @MolHorizons and led together with @LMSpenkelink, has been awarded an ARC Discovery Project Grant to tackle this fundamental question! 🎉 Postdoc & PhD opportunities coming soon! #Science
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🚨 We are looking for a new cryoEM 🔬 facility manager @SussexUni This is fantastic opportunity to work with leading researchers (like us @GDSC_Sussex) who want to observe the molecules of life and better understand human disease. https://t.co/WG1pLoWaEO
newscientist.com
 After many years of connecting brilliant minds with the world’s leading science employers, New Scientist Jobs has now closed . We want to express our heartfelt thanks to every employer, recruiter,...
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#UOW early career researchers Dr Lei Deng, Dr Xiaoning Li, Dr @MMavilidi, and Dr Rupeng Yang each received close to $500,000 as part of the @arc_gov_au Discovery Early Career Researcher Award prestigious fellowship scheme. 🎉 #UOWResearch
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Interested in how MALDI-2 enables @imaging_ms of metabolites at #singlecell resolution. Then check out @J_C_Mckinnon's latest paper. @uowresearch
https://t.co/7jpjimjzrm
pubs.acs.org
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) can provide valuable insights into the metabolome of complex biological systems such as organ tissues and cells....
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We are looking for a postdoc in #computchem #machinelearning at @UOW @arc_qubic @MolHorizons #chemjobs #ozchem · 3 years, full-time · Level A: $90,795 - $106,374 + 17% Superannuation · Deadline: 01/09/2024 Apply https://t.co/33rzThNa4K to join us in the beautiful Wollongong!
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UOW researcher Prof Martina Sanderson-Smith @DrmartinaS is among a national team of scientists shortlisted for this year’s Australian Museum Eureka Prize for their ongoing work into the clinical impact of StrepA infections in children. @uowresearch @UOW
https://t.co/zhhzTESgpZ
uow.edu.au
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I am seeking an enthusiastic postdoc to join my lab in Sydney to work on Nuclear Dynamics, DNA repair and genome stability. We offer innovative science, a competitive salary, and a supportive team. If you are interested, please get in touch with me: nlamm-shalem@cmri.org.au
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Delighted to share our paper containing the majority of my PhD work uncovering the mechanism of RAD51 removal from DNA by the AAA+ protein FIGNL1! It was a cross-Atlantic collaboration with @TaiYuanYu1 who provided the cell work! Tweetorial to come!
Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin https://t.co/f5tmFGQCBD
#biorxiv_biochem
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Congratulations @CostaLabCrick
Congratulations to group leaders Snezhka Oliferenko and Alessandro Costa (@CostaLabCrick) on being elected as members of @EMBO 🥳 https://t.co/LLZzXrzIzn
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What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
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Insight into Single-Molecule Imaging Techniques for the Study of Prokaryotic Genome Maintenance A review by Lisanne Spenkelink, Stefan Mueller et al @LMSpenkelink @StefanHMue @UOW 🔓 Open access in ACS Chemical & Biomedical Imaging 👉 https://t.co/QW0nJsBJbM
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It’s finally out! Glad to have contributed to this mammoth effort by Sarah!
How does Mcm10 activate an origin of replication? Find the answer in our paper published today in @NatureSMB. Congratulations to Sarah Henrikus & our fantastic lab! 🥳🎉 https://t.co/Qk8YRIPww8 Great collaboration with Marta, Allie and John from @DiffleyLab @TheCrick
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AlphaFold3 is insane. MutS protein (green) recognizes base mismatches in DNA (gray), after which it slides off to find MutL matchmaker protein (blue), which positions and activates MutH nuclease (pink) to nick a hemimethylated GATC sequence (red) to activate removal and repair of
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🚨 Join us! We're seeking a Lecturer in Cell & Molecular Bioscience at UOW. Leverage our world-class cryo-electron microscopy facility for pioneering research in structural biology. Apply now! Any questions reach out!
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🌟 Calling all rising stars in research! UOW's Vice-Chancellor’s Postdoctoral Research Fellowship awaits! With 3 fellowships available in any discipline, this is YOUR opportunity to shine on a global stage! Get in touch! See Link below!
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Coming down from the high of Taylor-related content with the Aus part of the Eras tour now over? I've got you covered. Introducing: 🔺Tetrahedral encapsulin protein cages (@taylorszyszka's version) https://t.co/W3bhVe5LVY Encapsulins form icosahedra. How did she make pyramids?
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It was great to bring together some of the researchers at Molecular Horizons to talk about collaboration impact and mentoring at our strategic planning day last week. We look forward to the year ahead and implementing the objectives that came out of the day @uowresearch
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