David A. Alagpulinsa, PhD
@Alagsdave
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Assistant Professor @Yale @YaleMed⏐Statistical & Molecular Genetics⏐Hematopoiesis⏐Neuroimmunology⏐Type 1 diabetes⏐Cardiometabolic disease⏐Nature, Virtue & Free⏐
New England, USA
Joined December 2012
In cognitively normal older adults at risk for Alzheimer’s dementia, physical inactivity was associated with faster tau protein buildup and cognitive decline https://t.co/5lEQV6aoT9
@WendyYau01 @HarvardAging @MGHNeurology
nature.com
Nature Medicine - In cognitively normal older adults at risk for Alzheimer’s dementia, physical inactivity was associated with faster tau protein buildup and cognitive decline.
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The growing prevalence of double diabetes T1D with added insulin resistance reminds us there is room for using adjunct therapies to improve metabolic health. @AnnalsofIM
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Postoperative Atrial Fibrillation and Risk of Development of Dementia | JACC: Advances
jacc.org
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Big news for Ghana and Africa’s research community! 🇬🇭🇪🇺 Congrats to Prof. George Meyiri Bob-Milliar of @KNUSTGH, the first Ghanaian and second African to win the prestigious @ERC_Research Synergy Grant! His team receives €10.3m for research on political parties and democracy.
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🎯Review @TheLancet The future of type 1 diabetes therapy. "New breakthroughs offer renewed hope for improving long-term management and quality of life for people living with type 1 diabetes." https://t.co/BzqIlCzuC0
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This @NatureGenet study screened for somatic mutations in healthy aged individuals, identifying expanded HSC clones accessible for lineage tracing of all major blood cell lineages. 🩸 ✅ Check it out! https://t.co/qkCjoQ63Rw
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Today’s Nature reports a study on the heritability of 34 human traits, showing that educational attainment and fluid intelligence (innate cognitive ability) have higher heritability than most other traits. https://t.co/qGV0Wit8rM
nature.com
Nature - WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 complex...
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Phenotypic pleiotropy of missense variants in human B cell confinement receptor P2RY8
cell.com
LaFlam et al. combine deep mutational scanning, structural biology, and machine learning to characterize how missense variants affect the expression and function of the immune GPCR P2RY8. Their...
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In the December issue: Life stage transitions for people with type 1 #diabetes
https://t.co/cEhkfWRo3A
#T1D
thelancet.com
Type 1 diabetes affects individuals of all ages, with different clinical priorities and support needs at different stages of life. In this Personal View, we define the two major transitions that...
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#Ghana diabetes study: 2/3 of individuals with long-term #T1D maintain C-peptide levels, challenging clinical diagnosis. Better differentiation from atypical diabetes forms needed to optimise care in limited-resource settings. #DiabetesResearch
https://t.co/ghqwWui3RU 🔓
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Spain’s own Dolores Corella (@UV_EG) will speak at @CellSymposia #CSAging2026 Don’t miss her insights into genetic epidemiology and aging. Join the program, abstract deadline June 5. https://t.co/AwxWLtPQn8
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Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts
cell.com
Mu et al. performed single-cell chromatin accessibility quantitative trait locus (caQTL) mapping in human peripheral blood mononuclear cells and found that caQTL explain roughly 50% more disease...
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Glucose Extremes and Cognitive Function: A Review of the Neurological Impacts of Hypoglycemia and Hyperglycemia in Type 1 Diabetes
diabetesjournals.org
This article explores the neurological impacts of hypoglycemia and hyperglycemia on cognitive function in type 1 Diabetes. It reviews how fluctuating gluco
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Glucose Extremes and Cognitive Function: A Review of the Neurological Impacts of Hypoglycemia and Hyperglycemia in Type 1 Diabetes
diabetesjournals.org
This article explores the neurological impacts of hypoglycemia and hyperglycemia on cognitive function in type 1 Diabetes. It reviews how fluctuating gluco
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A reminder that the abundance of 'housekeeping' proteins varies significantly across cells and tissues. GAPDH is often slandered as a 'housekeeping' protein, and its abundance varies significantly across human tissues. How do you define a 'housekeeping' protein ?
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Useful new eQTL resource for skeletal muscle from 1,002 individuals from a meta-analysis of GTEx and FUSION 👉12,283 eGenes & 18,818 signals 👉2,252 GWAS-eQTL colocalizations with 26 cardiometabolic traits across 1,342 candidate genes
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Blood stem cell clones, mistakenly known as CHIP (clonal hematopoiesis of indeterminate potential) because they are common in older adults and are a risk factor for heart disease and cancer. Today @JAMACardio a study in >410,000 @UK_biobank participants highlights the risk for
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A comprehensive view of somatic mosaicism by single-cell DNA analysis. #SingleCell #scDNAseq #SomaticMosaicism @biorxivpreprint
https://t.co/WxsoIX81Oj
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Results from the evoke trials with oral semaglutide #Alzheimersdisease are imminent. The real world data continues to arrive for GLP-1 medicines and #T2D
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