Tortora and Fudenberg derive a chemical-reaction network model explaining how cohesin regulators control loop extrusion from first principles. Experimental data uniquely support a “bursty extrusion”...

Zhu et al. present scalable approaches for leveraging genealogical graphs to study complex traits. They introduce ARG-RHE, a method for heritability estimation and gene-based association testing...

Shao et al. introduced a new approach for indel and structural variant genotyping, showing that these variants are far less error prone than SNVs, while repeat indel errors scale with repeat length....

Yang et al. present the structure and evolution and investigate the functional consequences of human chromosome 2 fusion, suggesting incomplete lineage sorting of complex regions during great ape...

Feng et al. present the first genome-scale CRISPR interference perturbation map with scRNA-seq readout across many genetic backgrounds in human pluripotent cells, pioneering population-scale CRISPR...

Helmy et al. provide a collection of high-quality mouse reference genomes. They were able to resolve some of the most complex regions among mouse genomes that are involved in immune defense. These...

Chen et al. present CellUntangler, a deep-learning model that utilizes a flexible latent space composed of multiple subspaces, allowing for the capture and filtering of biological signals in single...

Through large-scale sequencing analysis, Yu et al. found that cystic fibrosis risk variants reduce susceptibility to IBD. This finding opens the possibility of developing selective, tissue-targeted...

Leopard cats lived commensally with humans in ancient China for over 3,500 years before domestic cats were introduced via Silk Road merchants around 1,400 years ago. Ancient DNA shows that while two...

Polygenic scores can improve the power to detect gene-environment interactions, with implications for genome-wide interventions. Westerman et al. introduce a framework for comparing the performance...

Keele et al. uncover the genetic architecture of the proteome of fresh and stored red blood cells using a multi-omics analysis of 350 genetically diverse mice. Their work reveals how a hemoglobin...

Jang et al. demonstrate that protein language models expand coding-variant discovery in complex traits by improving gene-based tests and revealing transcript-level associations as well as mutations...

This study identifies a unique class of condensation-prone RNAs (smOOPs), defined by semi-extractability and enrichment in OOPS. smOOPs form denser-than-expected RNA-RNA subnetworks, display distinct...

Long-read sequencing and telomere-to-telomere (T2T) assemblies have enabled the generation of pangenomes that capture genetic diversity beyond single reference genomes. This review highlights how T2T...

Xiang et al. employ an integrative proteogenomic approach in colorectal cancer and uncover abundant tumor-specific antigens originating from non-coding regions. They demonstrate that these non-cano...

G protein-coupled receptors (GPCRs) form the largest family of cell surface receptors and remain a central focus in pharmacology and drug discovery. Despite extensive structural and pharmacological...

Unmodified class II bacteriocins promise precision antimicrobials that spare bystander microbes. Zhang and colleagues introduce IIBacFinder, a genomics-guided pipeline that detects precursor and...

Can individual cells retain a memory of past gene expression levels even after the stimulus has faded? In this issue of Cell Genomics, Domitilla Del Vecchio and colleagues describe an analog epigen...

Using single-cell genomics and advanced network analysis, Gupta et al. mapped gene networks in key brain cell types across schizophrenia, bipolar disorder, and autism. This innovative approach...

Yim et al. use single-cell transcriptomics to elucidate the molecular outcomes of Chd8 haploinsufficiency in the mouse cortex. Their results provide insight into dynamic, cell-type-biased transcrip...