The Lancet Diabetes & Endocrinology
@TheLancetEndo
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Your leading source of international, cutting-edge research, review, and opinion in clinical diabetes and endocrinology. IF=41·8.
London
Joined November 2013
The December Issue of @TheLancetEndo is now online, featuring familial hypercholesterolaemia, chronic kidney disease, type 2 diabetes, cyclic Cushing’s syndrome, primary aldosteronism, type 1 diabetes, menopause, obesity, iodine deficiency, & much more https://t.co/1LW4xvaLB1
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Our 4 paper Series on #PrecisionMedicine provides a framework for its integration in cardiometabolic disease, discusses the heterogeneity of #diabetes and #obesity, and explores the implications for its adoption in #LMICs. To find out more visit
thelancet.com
Obesity and diabetes are multifaceted and complex conditions, resulting from a combination of intrinsic and extrinsic factors. However, current approaches to prevention, screening and treatment still...
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Although heterozygous #familial #hypercholesterolaemia represents one of the most common monogenic conditions in the general population, homozygous familial hypercholesterolaemia is much rarer, occurring in between 1/160 000 & 1/450 000 individuals https://t.co/MP5vATtZp0
#ASCVD
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People with type 2 #diabetes are likely to be more susceptible to adverse health effects from PM2·5, which further amplifies #pollution-related #cardiovascular risk https://t.co/EKFS234XVV
#T2D #AirPollution #CVD
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For much of the 20th century, the diagnosis of adrenal tumours, defined as enlarged or atypical-appearing adrenal lesions that can be benign or malignant, relied on clinical suspicion of large palpable masses, hormonal manifestations, or autopsy findings https://t.co/mwjeqzstQ9.
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Adrenal tumours have become a common incidental finding in the radiological evaluation of patients. Estimates suggest that 1–10% of the general population currently harbours an adrenal tumour,...
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Eloralintide, a selective amylin receptor agonist for the treatment of obesity: a 48-week phase 2, multicentre, double-blind, randomised, placebo-controlled trial https://t.co/H1Kb3FKp3j
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Although very infrequent, cases of #hypothalamic #obesity are a challenging, often intractable medical condition, that can also help to elucidate mechanisms of obesity and eventually identify therapeutic targets https://t.co/3Be0ZzDvWp
#hyperphagia
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Male #hypogonadism caused by an intrinsic & often irreversible HPT pathology is called organic (also termed classical) hypogonadism. Organic hypogonadism has a straightforward, established diagnostic & treatment pathway https://t.co/k5ZVLahhjz
#testosterone #MensHealth
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The YOMEGA study is the first RCT providing long-term data comparing #weightloss, metabolic outcomes, and #safety with one anastomosis gastric bypass versus standard Roux-en-Y gastric bypass. Read the 5 years follow-up data here:
thelancet.com
OAGB was not inferior to RYGB regarding percentage excess BMI loss at 5 years with similar metabolic outcomes. The high rate of clinical gastro-oesophageal reflux disease after OAGB raises questions...
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The rise of ultra-processed foods is damaging public health, fuelling chronic diseases worldwide, and deepening health inequalities. Urgent, coordinated global action is needed to address the UPF challenge. Find out more in an Editorial ➡️ https://t.co/6hBuTB5XCv
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#Tirzepatide added to basal insulin improved glycaemic control and was generally well tolerated, providing evidence to support its potential therapeutic use in patients with type 2 #diabetes in China https://t.co/A2CPLlS5l3
#T2D
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The findings support arguments for widespread early use of #SGLT2 inhibitors to reduce the global burden of #kidney disease, to simplify current guidance on whom to treat, and to discourage routine remeasurement of eGFR after initiation https://t.co/e1njA9ojwQ
#CKD
#OpenAccess
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SGLT2 inhibition reduces risk of acute and chronic kidney outcomes irrespective of the size of the acute dip in eGFR. Kidney benefits are evident irrespective of diabetes status, heart failure...
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There is a major research gap as to the optimal management strategy for type 2 diabetes in adolescents and young adults, given that current models of care appear to not work as well in this age group. For more: https://t.co/KikG2M0rKu
#diabetes
thelancet.com
Type 2 diabetes diagnosed in childhood or early adulthood is termed early-onset type 2 diabetes. Cases of early-onset type 2 diabetes are increasing rapidly globally, alongside rising obesity....
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Linked Comment by Kevin S Fay & Debbie L Cohen: Primary #aldosteronism and plasma #renin targets https://t.co/LVChXtXIlq
#CVD
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Over the past two decades there have been tremendous advancements in the understanding of both the prevalence and the clinical significance of primary aldosteronism. Where previously only the most...
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The association between unsuppressed #renin following medical therapy for primary #aldosteronism and reduced risk of #cardiovascular events and all-cause mortality suggests that renin normalisation might serve as a therapeutic target https://t.co/y0iWBTIhKf
#CVD
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The association between unsuppressed renin following medical therapy for primary aldosteronism and reduced risk of cardiovascular events and all-cause mortality suggests that renin normalisation...
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Linked Comment by Dan Alexandru Niculescu: The road towards standardisation in cyclic #Cushing's syndrome https://t.co/4uD0k7x2ew
#pituitary
thelancet.com
Endogenous Cushing's syndrome is a severe, potentially lethal, endocrine condition. It is well known for its pleomorphic clinical manifestations that often overlap with those of frequent endocrine...
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Even in specialised centres, cyclic #Cushing's syndrome (cCS) diagnosis and management remain challenging with high rates of spontaneous adrenal insufficiency, inappropriate surgeries, and poor outcomes https://t.co/0ZfSwOraBZ
#pituitary
thelancet.com
Even in specialised centres, cCS diagnosis and management remain challenging with high rates of spontaneous adrenal insufficiency, inappropriate surgeries, and poor outcomes. Ectopic cCS showed the...
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Our January 2026 issue is out now: https://t.co/bK6A0hWWqa Content includes #MASH, #IBD, #PBC, #PSC, #ageing, #diet + more! #GITwitter #MedTwitter #LiverTwitter
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New—Social learning theories and metabolic health: the centenary of Bandura's birth https://t.co/BPgBn6d6P0
#FREE to read
thelancet.com
100 years ago, on Dec 4, 1925, Albert Bandura was born in a small rural Canadian town with limited educational resources. Encouraged by parents who valued education, he developed a remarkable...
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Lene Ringholm comments on: Does continuous glucose monitoring deliver in #gestational #diabetes? https://t.co/cnSMfb9KqG
#CGM #GDM #pregnancy #WomensHealth
thelancet.com
Women with gestational diabetes continue to have adverse pregnancy outcomes that are often related to hyperglycaemia. Maternal glucose is the major determinant of increased birthweight and there are...
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