RCT: Among patients with obstructive prosthetic heart valve thrombosis, tenecteplase achieved higher complete thrombolytic success (97.5%) than alteplase (81.5%) and a shorter hospital stay. https://t.co/5XoQ6k29v2

In this secondary analysis of the AZALEA-TIMI 71 RCT, abelacimab consistently reduced the risk of bleeding relative to rivaroxaban irrespective of kidney function. https://t.co/m8rsnyQct6

Why guess when you can know?

Editorial: The DANFLU-2 trial demonstrated that high-dose influenza vaccines have minor clinical advantages over standard-dose ones, highlighting the need for a health system focused on evidence rather than financial incentives. https://t.co/fdenJseLi6

On December 1 at 10 AM ET, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new @WHO guideline concerning #GLP-1 therapy and adults with #obesity. Register for the webinar: https://t.co/jYscwVTsaY

Among older adults, high-dose influenza vaccine modestly reduced cardiorespiratory and cardiovascular hospitalizations compared to standard-dose vaccine, finds this secondary analysis of the DANFLU-2 randomized clinical trial. https://t.co/d1PkUHkYUz

Among patients with severe symptomatic aortic stenosis at low to intermediate surgical risk, transcatheter aortic valve implantation was associated with a lower 1-year risk of all-cause death or any stroke. https://t.co/U4kAts6gtI

💬 Viewpoint: RCTs in tricuspid regurgitation indicate that transcatheter therapies can enhance quality of life and reduce certain clinical events compared to medical therapy. https://t.co/bXdqud9zhZ

On December 1 at 10 AM ET, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new WHO guideline concerning #GLP-1 therapy and adults with #obesity. Register for the webinar: https://t.co/WmfDVBXtXN

💬 Viewpoint: The TRILUMINATE Pivotal trial demonstrated improvement with transcatheter tricuspid repair, but effects on mortality and heart failure hospitalization were unclear or confounded by high crossover rates and open-label design. https://t.co/Uc2sy5XaKG

Severe tricuspid regurgitation (TR) remains associated with poor prognosis and presents diagnostic and treatment challenges. 📌 This Review summarizes the anatomy, clinical manifestations, and diagnostic and management strategies of TR. https://t.co/DxVBDK5hin

Editorial: By utilizing the @WHO’s STEPS framework to evaluate CV health across multiple countries, the study by Agboyibor et al highlights the potential for standardized global data to improve noncommunicable disease prevention. https://t.co/ArYE7eO57u

In @WHOAFRO, older age, female sex, lower levels of education, and heavy alcohol consumption were linked to a decreased likelihood of achieving ideal or intermediate cardiovascular health. https://t.co/eIXE9d8ecb

Editorial: Microaxial flow pump therapy may be most beneficial for myocardial infarction patients with cardiogenic shock experiencing severe hypotension despite vasopressor use. https://t.co/H5Z4vrFqMP

This post hoc analysis of the DanGer Shock RCT suggests that microaxial flow pump treatment may improve survival in patients with STEMI-related cardiogenic shock and profound systolic hypotension. https://t.co/Sq3pKzGrgq

Editorial: Schuermans et al's study links clonal hematopoiesis (CHIP) to acute inflammatory heart conditions, suggesting that CHIP mutations could serve as key biomarkers for predisposition to chronic and acute cardiac diseases. https://t.co/0ogLcoZWwl

Among middle-aged adults, clonal hematopoiesis of indeterminate potential (CHIP) was linked to an increased risk of developing myocarditis and pericarditis. https://t.co/IyJ2JqYnVX

Editor's Note: Herraiz-Adillo et al report that stage 2 hypertension and even modestly increased systolic blood pressure in young adulthood are independently associated with severe coronary stenosis in midlife. https://t.co/4R3GCE7ryZ

In this population-based cohort study, higher BP levels in adolescence were associated with a dose-dependent higher risk for atherosclerosis in middle age, particularly for severe coronary atherosclerosis. https://t.co/34ccM4F8tJ

Patients with peripartum, alcohol-induced, and cancer therapy–related cardiomyopathies had enriched monogenic variants and high polygenic risk scores for dilated cardiomyopathy, indicating shared genetic susceptibility. https://t.co/7njeeNxO4Y

In older patients with myocardial infarction and multivessel disease, physiology-guided complete revascularization achieved a sustained reduction in adverse outcomes compared to culprit-only treatment over a 3-year follow-up period. https://t.co/kZUI2Dl9G4