Truncating LMNA variants lead to worse arrhythmic outcomes regardless of position, whereas missense variants in the tail domain, particularly in exons 7 to 12, are associated with better cardiac outcomes.

Most viewed this week from @JAMACardio: . Chronic cannabis smoking and THC ingestion were associated with endothelial dysfunction similar to that observed in tobacco smokers.

Most viewed this week from @JAMACardio: . Chronic cannabis smoking and THC ingestion were associated with endothelial dysfunction similar to that observed in tobacco smokers.

Preoperative cardiovascular risk did not affect outcomes related to continuing vs discontinuing RAS inhibitors before major noncardiac surgery.

Gestational diabetes mellitus predominantly represents a marker of pre-pregnancy cardiovascular health (CVH).

Gestational diabetes mellitus predominantly represents a marker of pre-pregnancy cardiovascular health (CVH), highlighting the importance of improving CVH early in the life course.

Viewpoint: Management of severe asymptomatic aortic stenosis (AS) requires personalized decision-making, weighing the risks and benefits of early intervention against careful monitoring.

The American Heart Association's PREVENT equations accurately predicted CVD, ASCVD, and heart failure events across diverse Asian and Hispanic patient populations.

Viewpoint: Maternal mortality in the US has nearly doubled, highlighting the need for improved prepregnancy cardiovascular health.

Viewpoint: Financial insecurity (FI) is a significant but under-researched factor affecting cardiometabolic health, necessitating standardized definitions, validated tools, and innovative research.

The benefit of finerenone is consistent across the spectrum of baseline risk in patients with heart failure and mildly reduced and preserved ejection fraction.

Compared with cardiovascular risk scoring, coronary CT angiography was associated with modest improvements in healthier lifestyle behaviors, acceptance of recommended preventive therapy, and risk factor modification.

Valsartan may benefit early-stage hypertrophic cardiomyopathy by improving cardiac remodeling and reducing intracellular volume.

Cuffless blood pressure devices face accuracy and regulatory challenges but hold potential for improving BP control if these issues are resolved.

Editorial: The SCOT-HEART 2 substudy shows that CCTA screening for subclinical atherosclerosis better motivates lifestyle and therapy adherence than traditional risk scores.

Coronary CT angiography was associated with modest improvements in healthier lifestyle behaviors, acceptance of recommended preventive therapy, and risk factor modification.

Among patients with obesity-related HFpEF, treatment with HU6 for 19 weeks led to modest but statistically significant weight loss without significant changes in peak volume of oxygen consumption.

EchoNet-TR is a model for screening tricuspid regurgitation from single-view TTE videos with the potential to enhance TR screening access and enable retrospective institutional database reviews.

FINEARTS-HF: Finerenone reduced the risk of total worsening HF events and cardiovascular death, and it improved symptoms.

In this JAMA Cardiology Author Interviews episode, authors Michael McDermott and Pamela Douglas discuss CT Angiography, healthy lifestyle behaviors, preventive therapy, and more with host Ann Marie Navar.