AbdulAbdul
@Abdul_Squared
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@TriIMDPhD @junyue_cao lab @RockefellerUniv @WeillCornell (views are my own) Previously @broadinstitute @RutgersU-B.A
New York, NY
Joined March 2020
Excited to share my first work in @junyue_cao lab describing next generation, imaging free spatial transcriptomics-“IRISeq”. With IRISeq, we are able to perform scalable spatial transcriptomics analysis for various tissue sizes and adjustable resolutions..
Thrilled to introduce IRISeq, a scalable, cost-effective and imaging-free spatial genomic technique for mapping mammalian brain aging, developed by incredible Abdul @Abdul_Squared and Weirong from our lab at @RockefellerUniv! https://t.co/rvafkbYecP
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APOE E4 Alzheimer's Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex
biorxiv.org
The entorhinal cortex (ERC) is implicated in early progression of Alzheimer’s disease (AD). Here we investigated the impact of established biological risk factors for AD, including APOE genotype (E2...
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This guy’s Twitter account is a goldmine, I have to say. Oh yeah, those MD/PhDs are really cashing in! Maybe private practice orthopedic surgeons and cardiologists should consider this lucrative career path.
The physician–scientist track (MD/PhD) in academic medical centers has become one of the great illusions of modern science - a path that promises to unite medicine and science but rarely fulfills either goal. Training stretches on for years as one person is expected to learn two
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Congratulations to GSK PhD student Tiffany Merlinsky in the lab of @SantoshVardhana for defending her thesis entitled "Cysteine Availability Limits CD8+ T Cell Priming in Severe COVID-19"
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The Lipid Brain Atlas is out now! If you think lipids are boring and membranes are all the same, prepare to be surprised. Led by Luca Fusar Bassini with Gioele La Manno's lab, we mapped membrane lipids in the mouse brain at high resolution. https://t.co/q3AeqGsIS1
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Big, beautiful trees!! SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life. https://t.co/pciw5yME0x
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Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis. @Cell_Metabolism @RockefellerUniv
cell.com
Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as a key mediator of mitochondrial...
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🎉 After five years of dedicated PhD research, Xiao Su’s work is published! Resilience and perseverance prevail 💪 Mutations of the schizophrenia risk gene SETD1A dysregulate synaptic function in human neurons. Mol Psychiatry (2025). https://t.co/mYQdv7gYpB
@ChinjRutgers @RWJMS
nature.com
Molecular Psychiatry - Mutations of schizophrenia risk gene SETD1A dysregulate synaptic function in human neurons
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Two flagship papers from the International Brain Laboratory, now out in @Nature: 🧠 Brain-wide map of neural activity during complex behaviour → https://t.co/cVmZNqBlzZ 🧠 Brain-wide representations of prior information in mouse decision-making → https://t.co/Pd4bZQcECd +
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A model for propagation of RNA structural memory through biomolecular condensates:
nature.com
Nature Cell Biology - We hypothesize that stress-induced RNA structural changes, stabilized by RNA-binding proteins in biomolecular condensates, propagate via conformational catalysis in a...
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Our spatiotemporal atlas of brain aging under caloric restriction is out: https://t.co/15iBbqGLuX. Thanks to all authors, reviewers, and the great support from @RockefellerUniv, Brain Research Foundation (@TheBRF), and the Center for Integrated Cellular Analysis (@cegs_ica)!
Excited to share our first anti-aging intervention study, led by brilliant Zehao @Tommyz626, Alex @alexepstein_bio, and Chloe @chloe__schaefer from our lab at @RockefellerUniv! With a cost-effective spatiotemporal analysis pipeline, we identified the aging-associated cell
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Really sorry to lose one of the best scientists I met. A. James Hudspeth, neuroscientist who unlocked secrets of hearing, has died - News
rockefeller.edu
A. James Hudspeth, a Rockefeller neuroscientist who discovered how sound waves are converted into electrical signals in the ear’s cochlea, died Saturday at his home in Manhattan. A pioneering...
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Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging @NatureNeuro
https://t.co/LzC5p73oCg
nature.com
Nature Neuroscience - How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective...
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The brain-immune axis at work. Just photos of people with infections (using VR, avatars) activates the immune system (vs controls) https://t.co/SgVkTl8LbZ
https://t.co/T0umU5bLAk
nature.com
Nature Neuroscience - Serino et al. show that seeing an infectious avatar approach the body in virtual reality triggers an immune response, indicating that the brain prepares the body to fight...
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Excited to share that scPRS is now out @NatureBiotech! We developed a new single-cell-resolved #PRS using deep learning. https://t.co/6aX1QLzyDq
nature.com
Nature Biotechnology - A graph neural network framework enables individualized genetic risk prediction at the single-cell level.
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In an interview with @Elmedicoint, Rockefeller's Svetlana Mojsov reflects on how her discovery of GLP-1 has helped millions manage diabetes and obesity, and on the importance of mentorship, collaboration and translation in science: https://t.co/Wh0XLfgdxi
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On-demand microglia deliver the therapeutic payload in Alzheimer’s disease. @CellStemCell
https://t.co/EHR7DiPirg
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Congrats @LeWang74810712 on this amazing work!
Studies in mice of CNS GLP-1R circuits reveals that state-dependent synaptic regulation by GLP-1 in PVNGLP-1R→DVC descending circuits is important for energy homeostasis @NatMetabolism
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