Kivanc Birsoy
@KivancBirsoy
Followers
4K
Following
1K
Media
6
Statuses
629
Associate Professor at the Rockefeller University
Manhattan, NY
Joined April 2018
How does mitochondria sense and control their glutathione levels? Our new work @ScienceMagazine by a fantastic student @YuyangLiu1996 describing a redox metabolite sensing mechanism for mitochondria. @RockefellerUniv @TheMarkFdn
science.org
Blockage of an inner mitochondrial membrane protease stabilizes a glutathione transporter, enabling autoregulatory homeostasis.
46
156
657
RT @RockefellerUniv: Applications for faculty positions at Rockefeller are now open! We are seeking exceptional, creative scientists to joi….
rockefeller.edu
0
3
0
RT @RockefellerUniv: We are deeply saddened to share that our friend and colleague Jim Hudspeth passed away on Saturday. We will remember a….
rockefeller.edu
A. James Hudspeth, a Rockefeller neuroscientist who discovered how sound waves are converted into electrical signals in the ear’s cochlea, died Saturday at his home in Manhattan. A pioneering...
0
19
0
Mitochondrial GSH is essential for metastasis due to it function in signaling and iron homeostasis. We are grateful for the support of @TheMarkFdn and @theNCI for this project. Also thanks to many collaborators @RichPossemato @Aslan_Tasdogan.
0
3
12
New work from our lab describing a role for mitochondrial glutathione in breast cancer metastasis @nicoledelgaudio @RockefellerUniv
aacrjournals.org
Abstract. Cancer cells require substantial metabolic adaptations to metastasize to distant organs, but the metabolites essential for successful colonization remain poorly defined. Here, we used a...
2
28
130
Congrats @JaviGBermudez for this well deserved honor! Looking forward to many discoveries from your lab!.
Honored to be named a 2025 Pew-Stewart Scholar for Cancer Research. Grateful for the support and excited for the science ahead!.
1
0
6
Congratulations @TimCKenny for your new position! Looking forward to many discoveries in your lab at @IcahnMountSinai !.
Thrilled to announce that I will be joining the Cardiovascular Research Institute at @IcahnMountSinai as an Assistant Professor in January! My laboratory will focus on nutrient transport and cellular metabolism in physiology and disease.
1
0
20
Congrats @JaviGBermudez lab on this fantastic discovery! So well deserved!!! This needs to be considered for future ferroptosis work in vivo.
My lab's first paper is out in @Nature. We show that lipoprotein uptake protects tumors from ferroptosis by delivering the lipid antioxidant α-tocopherol. Surprisingly, tumors use sulfated glycosaminoglycans—not canonical receptors—to capture lipoproteins.
1
3
47
RT @CellPressNews: #CSMetabolites2025: Explore the latest on Metabolites: Organellar communication in health & disease. May 11–13, 2025, in….
0
1
0
RT @CellPressNews: Join @CellSymposia #CSMetabolites2025, May 11–13, 2025, in Sitges, Spain—featuring Lulu Cambronne (@LACambronne, @UTAust….
0
4
0
RT @Cell_Metabolism: Register now for @CellSymposia #CSMetabolites2025, May 11–13, 2025, in Sitges, Spain! .Explore cutting-edge research w….
0
5
0
RT @ArtemAKhan: Excited to share our perspective on solute carrier transporters - gatekeepers of metabolism @Kivan….
0
21
0
RT @Cell_Metabolism: Last Chance! Deadline Today! Don’t miss your opportunity to submit an abstract for @CellSymposia Metabolites: Organel….
0
4
0
RT @Krista_Bledsoe: I'm excited to be co-organizing a Cell Symposia on metabolites in organellar communication with @KivancBirsoy, @Roberto….
0
15
0
RT @NatMetabolism: REVIEW | @KivancBirsoy, @abu_remaileh and colleagues (@RockefellerUniv, @Stanford) . The authors provide a broad overvie….
0
7
0
Beautiful story by @SohailTavazoie describing a genetic basis for metastasis. @RockefellerUniv.
A commonly inherited genetic variant of human PCSK9 drives breast cancer metastasis and associates with reduced patient survival. @CellCellPress PCSK9 drives pro-metastatic genes by repressing LRP1. Anti-PCSK9 antibody has breast CA metastasis suppressive effects.
1
2
19
Congrats @JaviGBermudez for this well deserved recognition!.
Grateful to receive the NIH Director’s New Innovator Award #NIHHighRisk.Congratulations to all the amazing investigators in this cohort.
1
1
19
RT @Vilcek: 💡@RockefellerUniv reports on new research published by @KivancBirsoy in @Nature, indicating how #Cancer cells use lipids to con….
rockefeller.edu
“Every time people have studied nutrient sensing, we’ve learned a lot about biology, and many drugs have been developed as a result.”
0
3
0
RT @CellSymposia: Share your research w/ organizers Kivanc Birsoy @KivancBirsoy @RockefellerUniv, Roberto Zoncu @RobertoZoncu @UCBerkeley,….
0
6
0
Great to see other groups also showing a role for glycosphingolipids in immune evasion :
nature.com
Nature Communications - Glycosphingolipids (GSLs) are abnormally expressed in cancer cells. Here, in addition to showing that inhibition of the synthesis of GSLs with eliglustat promotes anti-tumor...
0
3
28