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Joined May 2019
RT @artemnemudryi: First preprint from the Nemudryi Lab!. In this work, we link antiviral immunity in bacteria and humans by showing that h….
biorxiv.org
Human Schlafen proteins restrict viral replication by cleaving tRNA, thereby suppressing protein synthesis. Although the ribonuclease domain of Schlafen proteins is conserved across all domains of...
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RT @pacyc1841: Prophages block cell surface receptors to preserve their viral progeny | Nature
nature.com
Nature - Zip promotes the accumulation of free phages in bacterial lysogen communities, safeguarding phage progeny.
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RT @EricTopol: Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism".—the 1st hu….
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RT @MCB_UJ: 📣 New in @embojournal : .Our researchers lead by @GlattSebastian , together with @IIMCB_Warsaw, @durham_uni & @synchroSOLEIL r….
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RT @HarvardMicro: Joel Tan @JoelMJTan discovers a DNA molecular tripwire that guards against viral infection. New research from the Kranzus….
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RT @rafapinilla92: Excited to share our last collab paper, now out in print @ScienceMagazine!🎉. We reveal how dITP synthesis activates a SI….
science.org
Signaling from pathogen sensing to effector activation is a fundamental principle of cellular immunity. Whereas cyclic (oligo)nucleotides have emerged as key signaling molecules, the existence of...
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RT @biorxiv_micrbio: Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity #bior….
biorxiv.org
7-deazapurines are nucleobase analogs essential for nucleic acid modifications in nearly all cellular life. Here, we discover a role for 7-deazapurines in protein modification within type IV CBASS...
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RT @LabWaggoner: Darn, they stole my rapper alias.'Jumbo phage killer' immune system targets early infection of nucleus-forming phages.http….
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RT @MartinPacesa: Novel phage-derived Cas12 system discovered that interacts with E.coli Thioredoxin and regulates its activity. https://t….
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RT @JeremyFarrar: A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors
science.org
In 2024, several human infections with highly pathogenic clade 2.3.4.4b bovine influenza H5N1 viruses in the United States raised concerns about their capability for bovine-to-human or even human-t...
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RT @cellhostmicrobe: Salmonella RemAIN(s).@SophieHelaine reveals prophage-encoded anti-phage defense element, RemAIN, that blocks lytic cyc….
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RT @BaharogluZeynep: GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome
biorxiv.org
The bacterial chaperonin GroEL/ES promotes protein folding post-translation by transiently encapsulating substrate proteins within a central chamber. GroEL also binds translating ribosomes in vivo ,...
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RT @hauryliuk: We cracked the tRNA specificity of FaRel2 toxSAS. A fun collaboration with the @SuzukiRNALab, Garcia-Pino @gem__atkinson and….
science.org
The toxSAS FaRel2 inspects four base pairs of the tRNA acceptor stem to specifically select tRNAGly and tRNAThr.
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Thrilled to share my latest postdoc paper published in.@NatureComms.NTase toxin targeting serine tRNA 3'-ends by CMP addition in M. tuberculosis H37Rv. Thanks to all the co-authors,.@GenevauxPierre.@BlowerLab.@ONeyrolles.
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RT @biorxiv_micrbio: Phage CRISPR-like regulatory RNAs silence bacterial adaptive and innate immunity #biorxiv_mic….
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RT @BlowerLab: New MenT toxin-antitoxin paper for perusal! There are multiple routes to inhibit MenT toxins. Whilst phosphorylation was pre….
nature.com
Nature Communications - Bacteria harness toxin-antitoxin systems to manipulate growth and evade stress. Using biochemistry, biophysics, and crystallography, the authors characterize a mechanism of...
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RT @biorxivpreprint: Full-length tRNAs lacking a functional CCA tail are selectively sorted into the lumen of extracellular vesicles https….
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RT @crypticprophage: Instead of using a toxin/antitoxin to respond to macrophage H2O2 stress, S. enterica uses prop….
science.org
Phage viruses shape the evolution and virulence of their bacterial hosts. The Salmonella enterica genome encodes several stress-inducible prophages. The Gifsy-1 prophage terminase protein, whose...
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