Vasili Hauryliuk
@hauryliuk
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a ribosomologist in a phage-infested lab
Lund, Sverige
Joined May 2008
Evolutionary adaptation of bacterial proteomes to translation-impeding sequences | The EMBO Journal
link.springer.com
The EMBO Journal - Microbial translation arrest peptides monitor intracellular environments and feedback-regulate downstream gene expression. Previous studies have identified a class of bacterial...
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Rethinking what pLDDT really tells us about protein flexibility
cell.com
Deep-learning models have transformed structural biology by enabling reliable prediction of protein 3D structure models and providing confidence metrics such as predicted local distance difference...
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Phages are full of genes of unknown fxn that may be adaptive in specific conditions. New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out https://t.co/JrB3J0ZytA
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Check this out for the 2026 SISB (phage defense) meeting in NYC. Mark your calendar! (and note the Zoom option, if needed) https://t.co/eyaobNZmUZ
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Challenging AlphaFold in predicting proteins with large-scale allosteric transitions
nature.com
Communications Chemistry - Although many proteins function by toggling between distinct conformations, most structure predictors remain limited to a single static fold. Here, the authors test the...
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ZAK activation at the collided ribosome @Nature
https://t.co/61D8QRbQhz
nature.com
Nature - The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.
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Another jump for genome editing today by @davidrliu and colleagues, addressing the ~11% of nonsense mutations that lead to premature stop codons, affect protein synthesis, and suitable for disease agnostic intervention @Nature @NatureNV
https://t.co/7Wxy1kgznp
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tRNAs for the win!
Today in @Nature we report a new prime editing strategy that can rescue a common cause of many genetic diseases in a disease-agnostic manner. This approach converts a redundant endogenous tRNA into an optimized suppressor tRNA, enabling a single prime edit to rescue premature
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𝗛𝗼𝘄 𝗳𝗮𝗿 𝘄𝗶𝗹𝗹 𝘃𝗶𝗿𝘂𝘀𝗲𝘀 𝗴𝗼 𝘁𝗼 𝗼𝘂𝘁𝘀𝗺𝗮𝗿𝘁 𝗖𝗥𝗜𝗦𝗣𝗥? 𝗙𝗮𝗿 𝗺𝗼𝗿𝗲 𝗰𝗿𝗲𝗮𝘁𝗶𝘃𝗲𝗹𝘆 𝘁𝗵𝗮𝗻 𝘄𝗲 𝗶𝗺𝗮𝗴𝗶𝗻𝗲𝗱! Excited to share our latest work on a Type III-A based anti-CRISPR, now published in Nature Microbiology.
nature.com
Nature Microbiology - Streptococcus thermophilus phages circumvent host CRISPR defences via AcrIIIA2, which complexes with enolase, a highly abundant glycolysis enzyme, to block phage RNA binding.
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Natural and artificial variations of the standard genetic code "...synthetic biologists often seem unaware of the developments in the other camp’s field, such as different codon reassignments and genetic code variants reported to occur naturally" https://t.co/KAjiKF19pI
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Att samla fager är lite som att fiska – man vet aldrig vad man får på kroken! Svansälskande fag Kompetensportalen levererar! @lunduniversity @NDPIAprogramme
medicin.lu.se
Lunds universitet. Bakteriofager – ofta förkortade till fager – är virus som angriper bakterier. Fager är häpnadsväckande effektiva mördare – dessa små virus utplånar 20 procent av alla bakterier på...
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Congratulations to #postdoc @cryoHuaxinYu @JunLiuLab @YaleMed for insightful findings @ScienceAdvances #cryoEM #cryoET #Lambdaphage Structural basis of bacteriophage Ur-lambda infection initiation
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Microbiome delivery of CRISPR-associated transposases enables stable genomic integration of multikilobase DNA payloads in gut-associated microbes in vivo. #NBThighlight
science.org
Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce...
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Online Now: Monitoring the complexity and dynamics of mitochondrial translation https://t.co/qWm5mmFgnN
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Documents discovered in 2023 revealed more about Rosalind Franklin’s role in solving DNA’s structure https://t.co/xFInOsVms9
nature.com
Nature - Hear the biggest stories from the world of science | 26 April 2023
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Phages isolated during the 2023 edition of the Fundamentals of Basic and Applied Phage Biology @NDPIAprogramme course at Lund University are out! Phages from the 2025 edition of the Fundamentals are already sequenced and will be reported in 2026.
journals.asm.org
Bacterial anti-phage defense systems are central to microbiology and have applications in biotechnology and medicine. Phage collections are key tools for uncovering and studying these systems. By...
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A membrane-bound nuclease directly cleaves phage DNA during genome injection https://t.co/YZfmmtXhIG
biorxiv.org
From mammals to bacteria, the direct recognition and cleavage of viral nucleic acids is a potent defense strategy against viral infection, but it requires mechanisms for distinguishing self from...
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This is cool!
Adapting CRISPR-associated transposons for rapid and high-throughput reverse genetics https://t.co/bKOs6Zl8rv
#biorxiv_micrbio
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Cryo-EM Structure Illuminates How a Designed Peptide Precisely Pauses the Ribosome https://t.co/LBkyDcWhvG
#CryoEM #Ribosome #eRAP
@IBCSinica
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A mysterious retron with a not-so-non-coding RNA!🧬 Super fun collab with the Shipman lab🚀Learned a lot from their creative setups (check them out!!)💡
Been working on a really strange retron bacterial immune system, here's the preprint: https://t.co/iWP8qH1Fe7 Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
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