Zeynep Baharoglu
@BaharogluZeynep
Followers
1K
Following
1K
Media
24
Statuses
1K
Scientist - Group leader at Institut Pasteur Paris - Bacterial stress responses, sub-MIC antibiotics, AMR, RNA modifications
Paris France
Joined October 2021
⬇️⬇️🐾🦋
find me there => @zeynepbaharoglu.bsky.social 🦠💫 I'll continue posting about bacteria, stress, RNAs, antibiotics, ...
0
0
1
🧬Fresh RNA modifications newsletter out now: viral tRNA hijacking, hidden rRNA mods, dynamic Ψ, antibiotic resistance & more. 👉 https://t.co/4ie8oRSHxR
#Epitranscriptome 🦠 #RNAmodification #ribosome
0
0
1
So excited our antibiotic potentiation story is out @ScienceAdvances 🤩 Led by the extraordinary @ManonLang_ with Stéphane Renard,@amazeld +amazing collaborators @ImmunoBladder Imane El Meouche🦠 We believe it can make a difference in #AMR infections! 🔗
science.org
Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.
2
10
33
Comprehensive nucleoside analysis of archaeal RNA modification profiles reveals an m7G in the conserved P loop of 23S rRNA
cell.com
Tsai et al. describe comprehensive nucleoside profiles of archaeal RNAs and identify temperature-responsive modifications using LC-MS/MS. They establish a workflow for RNA-modifying enzyme discovery...
0
1
6
Deep mutational scanning of an S. pneumoniae FMN riboswitch reveals robustness during mouse infection but diverging adaptive landscapes in response to targeting antibiotics 🦠💫 from Michelle Meyer lab
biorxiv.org
RNA-based control of gene expression is common across all domains of life, yet shows extraordinary variety in terms of environmental cues recognized, mechanisms of action, required protein factors,...
0
0
5
Happy to be at the Microbes and RNA meeting at Strasbourg for inspiring talks and discussions. #RNA2025 @MeetingRna
1
0
6
🌟📢 The September 1st issue of RNA Modifications Digest is here 🧬 From frameshift-preventing tRNA mods to aa-tRNA-seq breakthroughs and hidden damage by Tgt, and check also the preprints. 🦠💫 #microsku #rnasky
https://t.co/xMyCqKEYPX
1
2
11
🌟📢 The September 1st issue of RNA Modifications Digest is here 🧬 From frameshift-preventing tRNA mods to aa-tRNA-seq breakthroughs and hidden damage by Tgt, and check also the preprints. 🦠💫
0
0
1
Vibrio cholerae motility is associated with inter-animal transmission https://t.co/OG9MRPW31m 🦠
nature.com
Nature Communications - Determinants of Vibrio cholerae transmission are incompletely understood. Here, the authors use an infant mouse model to show that events in the intestine govern...
0
0
0
Mechanism of 30S subunit recognition and modification by the conserved bacterial ribosomal RNA methyltransferase RsmI 🦠
biorxiv.org
Ribosomal RNA (rRNA) modifications are important for ribosome function and can influence bacterial susceptibility to ribosome-targeting antibiotics. The universally conserved 16S rRNA nucleotide...
0
0
1
The tRNA dihydrouridine synthase DusA has a distinct mechanism in optimizing tRNAs for translation https://t.co/VapL0EjkzN 🦠 DusA enhances charging for some tRNAs with direct impact of D20 in translation. Not a broad chaperone role. From @UteKothe lab with @KoutmouLab 💫👏
biorxiv.org
Dihydrouridine (D) is one of the most highly conserved RNA modifications across all domains of life. D20 within the tRNA D loop is particularly conserved and is formed by DusA in Escherichia coli....
0
0
1
Vibrio cholerae motility is associated with inter-animal transmission
nature.com
Nature Communications - Determinants of Vibrio cholerae transmission are incompletely understood. Here, the authors use an infant mouse model to show that events in the intestine govern...
0
0
3
Robust antibiotic sensitization of pathogenic Pseudomonas aeruginosa via negative hysteresis in the cell envelope. with Cpx, beta-lactams and aminoglycosides
biorxiv.org
Antibiotic combination in time and space is a key strategy to combat antimicrobial resistance. The success of such treatment designs requires their robust efficacy across treatment conditions and a...
0
0
3
Check out our latest research on stress-induced small proteins @scisignal Congratulations to @vsangeev @premal_shah and all the co-authors 🎉
What are the roles of small proteins in #Ecoli? Using ribosome profiling, a team studies small proteins induced by magnesium starvation and show that one named YoaI activates a two-component system linked to osmotic stress response. @ScarletSam
https://t.co/vNalCQf5Oa
0
5
10
A single E. coli cell, placed on a dish, will become 70 billion cells in just 12 hours. That’s exponential growth. But a new preprint shows that it's possible to engineer E. coli to grow linearly instead, where only one daughter cell continues dividing and the other stops.
21
169
912
Artificially modulating tRNA availability boost translation - Chemically synthesized tRNAs with multiple modifications, exhibit ~4-fold higher decoding efficacy than unmodified tRNAs 💫
nature.com
Nature Communications - The Covid-19 vaccinations showed the potential for mRNA vaccines; however, the technology still has low translation capacity. Here, the authors report on a method of...
0
4
30
Adaptive genetics reveals constraints on protein structure/function by evolving E. coli under constant nutrient limitation
bmcbiol.biomedcentral.com
Background Evolution of microbes under laboratory selection produces genetically diverse populations, owing to the continuous input of mutations and to competition among lineages. Whole-genome...
0
2
5
Machine learning in understanding environmental variability of vibriosis in coastal waters 🦠 #microsky #vibrio temperature, salinity, and phytoplankton: important environmental parameters for vibrio proliferation
journals.asm.org
Vibrio spp. are ecologically significant bacteria, and their incidence and proliferation are strongly influenced by environmental factors. In recent years, Vibrio spp. infections have been reported...
0
0
0
Climate change and Vibrio: Environmental determinants for predictive risk assessment | PNAS
pnas.org
Climate change significantly impacts the incidence and abundance of microorganisms, including those essential for environmental cycles and those pa...
0
0
1
An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting 🦠 m1G (TrmD) at position 37 modulates tRNA conformation on ribosome and suppresses +1 FS induced by tRNA-Pro (four base pair codon-anticodon) https://t.co/NRrxZFSb8p 💫
nature.com
Nature Communications - tRNAs contain many chemical modifications that regulate their function. Integrating smFRET and cryo-EM approaches, this work demonstrates that m1G37 in tRNAProL stabilizes...
1
0
15
Analysis of stress-induced small proteins in Escherichia coli reveals that YoaI mediates cross-talk between distinct signaling systems 🦠 from @ScarletSam Yadavalli lab. Ribo-seq study of Mg2+ starvation induced 17 small proteins 💫 https://t.co/hPb9KB0jWC
biorxiv.org
Bacterial small proteins (≤ 50 amino acids) are an emerging class of regulators that modulate the activity of signaling networks that enable bacterial adaptation to stress. The Escherichia coli...
0
0
7