Tim Blower
@BlowerLab
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Senior Scientist at New England Biolabs and Honorary Professor at Durham University. Views my own. He/him.
New England Biolabs, MA
Joined September 2020
Latest BREX story from the lab - turns out there is a nuclease after all! Congrats to Jenny Readshaw and the whole team, including wonderful collabs Barry Stoddard, Brett Kaiser and @DarrenSmithdx. @NAR_Open @NEBiolabs @DurBiol
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RT @antonia_sagona: We are delighted to host Professor Tim Blower @BlowerLab as keynote speaker to our MID symposium.@WarwickLifeSci.Date:….
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RT @GiusyM1990: For those of you who approached me at @MicrobioSoc #Microbio25 (and anyone else interested!!), this is your last chance to….
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The post will be based in Ipswich, MA, north of Boston. Non-US citizens welcome (if eligible for a J-1 visa). The focus will be on basic research leading to publications. We provide an academic research and training environment, with >20 research labs.
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The lab is now up and running at New England Biolabs @NEBiolabs! I'm looking for a postdoc to study phage defence systems. If you'd like the academic freedom to publish but the resources of industry, then take a look 🤓😃
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Super opportunity to join Giusy in Glasgow!.
🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now !
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RT @GiusyM1990: The final version of our Serratia paper is now out! Congrats to @TomCX99 and (X-less) Suraj, and a big thank you to @Blower….
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RT @GiusyM1990: Over the moon to share some amazing news—I’ve been awarded an MRC Career Development Award to pursue my research at the Uni….
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RT @dghilarov: Using cryoEM we understood the structural basis of chiral DNA wrap by bacterial gyrase (and also produced the most complete/….
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RT @xibing4: Thrilled to share my latest postdoc paper published in.@NatureComms.NTase toxin targeting serine tRNA 3'-ends by CMP addition….
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RT @rafapinilla92: When experiments don’t work. build a phage costume! 🎃. Happy PHAGEOWEEN!!! 👻🧬#Teamwork
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RT @crypticprophage: Our thoughts on how toxins bound to TAs are activated: via conformation changes, not by select….
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RT @NatureComms: Researchers @blowerlab and colleagues use biochemistry, biophysics, and crystallography to characterize a mechanism of ant….
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RT @GenevauxPierre: Congratulations to @BlowerLab and @tomarrow234.Happy to be involved in this wonderful collaboration!.NTase toxins are t….
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Many congrats to lead author @tomarrow234 and all the team, including fab collaborators Dr Agnieszka Bronowska and @GenevauxPierre. Thanks to @MosmedC @acmedsci for funding.
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New MenT toxin-antitoxin paper for perusal! There are multiple routes to inhibit MenT toxins. Whilst phosphorylation was previously identified, the mechanism was unknown. We present a model wherein the antitoxin causes auto-phosphorylation of the toxin
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RT @maxewilkinson: My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? Th….
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Huge congrats to lead author Dr Sam Went and all wonderful collabs @jay_salsa @GiusyM1990 @DarrenSmithdx @NEBiolabs @NWenner. Thanks for funding go to @MosmedC @Multi_Defence @NLD_BBSRCDTP @ListerInstitute @wellcometrust @BBSRC.
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Our analysis of the PglX methyltransferase from BREX phage defence is now out! We were able to rationally engineer DNA sequence recognition to target new phages, meaning PglX is the specificity factor for BREX methylation and defence.
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