Tim Blower
@BlowerLab
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Senior Principal Investigator at New England Biolabs and Honorary Professor at Durham University. Views my own. He/him.
New England Biolabs, MA
Joined September 2020
RptR is a new addition to the growing collection of phage defence-associated transcriptional regulators. Congrats to @YugengZ @TangLabOxford @_MarionSchuller @IvanAhelLab and thank you, it was a pleasure to help out the study! @NEBiolabs.
academic.oup.com
Abstract. Bacteria encode a panoply of defence systems to overcome phage infection. In recent years, over 100 defence systems have been identified, with th
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Latest BREX story from the lab - turns out there is a nuclease after all! Congrats to Jenny Readshaw and the whole team, including wonderful collabs Barry Stoddard, Brett Kaiser and @DarrenSmithdx. @NAR_Open @NEBiolabs @DurBiol
academic.oup.com
Abstract. BREX (Bacteriophage Exclusion) systems, identified through shared identity with Pgl (Phage Growth Limitation) systems, are a widespread, highly d
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RT @antonia_sagona: We are delighted to host Professor Tim Blower @BlowerLab as keynote speaker to our MID symposium.@WarwickLifeSci.Date:….
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RT @GiusyM1990: For those of you who approached me at @MicrobioSoc #Microbio25 (and anyone else interested!!), this is your last chance to….
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The post will be based in Ipswich, MA, north of Boston. Non-US citizens welcome (if eligible for a J-1 visa). The focus will be on basic research leading to publications. We provide an academic research and training environment, with >20 research labs.
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The lab is now up and running at New England Biolabs @NEBiolabs! I'm looking for a postdoc to study phage defence systems. If you'd like the academic freedom to publish but the resources of industry, then take a look 🤓😃
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Super opportunity to join Giusy in Glasgow!.
🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now !
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RT @GiusyM1990: The final version of our Serratia paper is now out! Congrats to @TomCX99 and (X-less) Suraj, and a big thank you to @Blower….
cell.com
Cummins, Songra et al. identify three Serratia defense islands co-localizing anti-phage systems, virulence factors, and anti-bacterial factors. These islands provide a resource for discovering...
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RT @GiusyM1990: Over the moon to share some amazing news—I’ve been awarded an MRC Career Development Award to pursue my research at the Uni….
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RT @dghilarov: Using cryoEM we understood the structural basis of chiral DNA wrap by bacterial gyrase (and also produced the most complete/….
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RT @xibing4: Thrilled to share my latest postdoc paper published in.@NatureComms.NTase toxin targeting serine tRNA 3'-ends by CMP addition….
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RT @rafapinilla92: When experiments don’t work. build a phage costume! 🎃. Happy PHAGEOWEEN!!! 👻🧬#Teamwork
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RT @crypticprophage: Our thoughts on how toxins bound to TAs are activated: via conformation changes, not by select….
journals.asm.org
Toxin/antitoxin (TA) systems are found in almost all bacteria and archaea (1) and are currently classified into eight groups based on whether the toxin and antitoxin are proteins or RNAs and how they...
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RT @NatureComms: Researchers @blowerlab and colleagues use biochemistry, biophysics, and crystallography to characterize a mechanism of ant….
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RT @GenevauxPierre: Congratulations to @BlowerLab and @tomarrow234.Happy to be involved in this wonderful collaboration!.NTase toxins are t….
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Many congrats to lead author @tomarrow234 and all the team, including fab collaborators Dr Agnieszka Bronowska and @GenevauxPierre. Thanks to @MosmedC @acmedsci for funding.
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New MenT toxin-antitoxin paper for perusal! There are multiple routes to inhibit MenT toxins. Whilst phosphorylation was previously identified, the mechanism was unknown. We present a model wherein the antitoxin causes auto-phosphorylation of the toxin
nature.com
Nature Communications - Bacteria harness toxin-antitoxin systems to manipulate growth and evade stress. Using biochemistry, biophysics, and crystallography, the authors characterize a mechanism of...
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RT @maxewilkinson: My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? Th….
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Huge congrats to lead author Dr Sam Went and all wonderful collabs @jay_salsa @GiusyM1990 @DarrenSmithdx @NEBiolabs @NWenner. Thanks for funding go to @MosmedC @Multi_Defence @NLD_BBSRCDTP @ListerInstitute @wellcometrust @BBSRC.
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