bioRxiv Microbiology
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Joined July 2016
Host transcriptional responses to gut microbiome variation arising from urbanism https://t.co/GwFxIMJWPc
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Gut microbiomes of urban communities are compositionally different from their rural counterparts, and are associated with immune dysregulation and gastrointestinal disease. However, it is unknown...
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A family of endonucleases that block nanotube-mediated plasmid dissemination https://t.co/zVrqFD8Uxr
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Small non-conjugative plasmids constitute a substantial portion of the bacterial mobile genome, driving the dissemination of beneficial genes, with their transfer primarily attributed to transforma...
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Topical Formulation of Repurposed FDA-Approved Compounds Inhibits Pseudomonas aeruginosa ExoU and Improves Corneal Infection Outcomes https://t.co/sCMiAWRV2v
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Microbial keratitis, infection of the cornea, cause by ExotoxinU (ExoU) strains of Pseudomonas aeruginosa have a poor clinical outcome and response to antimicrobials. ExoU, a phospholipase, is...
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A bioluminescence-based chemical screen identifies a bactericidal naphthalene scaffold targeting MmpL3 in Mycobacterium abscessus https://t.co/dCz0xnk6pO
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Mycobacterium abscessus pulmonary disease (Mabs-PD) presents a significant and growing global health threat, particularly in individuals with underlying lung conditions like cystic fibrosis and...
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Engineering auxin degradation into root-associated bacteria promotes plant growth https://t.co/EdWvlkmdme
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Overproduction of indole-3-acetic acid (IAA) by rhizosphere bacteria disrupts auxin homeostasis and induces root growth inhibition (RGI) in plants. Bacteria from the genus Variovorax mitigate this...
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Single-component self-assembling protein nanoparticles displaying stabilized prefusion-closed hemagglutinin trimers for influenza ... https://t.co/SHRMzc4Bta
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Current influenza vaccines primarily target hemagglutinin (HA), the major surface glycoprotein and principal determinant of neutralizing antibody (NAb) responses. However, antigenic drift and shift,...
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Plasmid dependent phage eliminate pathogenic bacteria and antibiotic resistance plasmids from the chicken gut microbiome https://t.co/tJe7yN6ZHi
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Conjugative plasmids are a key reservoir of antimicrobial resistance (AMR) in commensal and pathogenic bacteria within the gut microbiome. Plasmid-dependent phage (PDPs) are a promising therapeutic...
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Species-Specific gB Ectodomain Interactions and Cytoplasmic Domain Stability Regulate Herpes Simplex Virus Fusion https://t.co/sC9q1FJwHo
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Entry of herpesviruses into cells requires coordinated action of multiple viral glycoproteins, including gH/gL and gB which comprise the core fusion machinery conserved in herpesviruses. The gH/gL...
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Untangling the diversity of Trypanosomes infecting Colombian amphibians: morphometric and molecular insights https://t.co/FN8rQIJjs0
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Amphibians, though widely distributed and diverse, are increasingly threatened by environmental changes and emerging diseases. Among the lesser-known yet prevalent pathogens affecting them are...
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Lysosomal permeabilization by Group A Streptococcus releases proteins into the macrophage cytosol https://t.co/toIXIEMvzw
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The human-specific bacterial pathogen Group A Streptococcus (GAS) is a significant cause of morbidity and mortality due to its ability to cause severe invasive infection. Although macrophages are...
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Biosynthesis cost and catabolic pathway length explain frequency of amino acid utilization as carbon sources by bacteria https://t.co/rIaAgoADBd
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Heterotrophic bacteria exhibit remarkable taxonomic and metabolic diversity. Experimental phenotyping of individual strains is often impractical due to the diversity of metabolic strategies, highli...
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An N4-like Caulobacter phage requires host smooth lipopolysaccharide biosynthesis for infection https://t.co/COEIovcmfD
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Caulobacter species are Alphaproteobacteria that commonly inhabit plant-associated and aquatic microbial communities. Although Caulobacter is widespread and has long served as a model for the study...
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Coenzyme A depletion causes antibiotic tolerance in Pseudomonas aeruginosa https://t.co/5QRv2v6TCz
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The widespread use of antibiotics promotes both resistance and tolerance. While resistance enables bacterial growth in the presence of drugs, tolerance allows survival during treatment, generating...
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Wheat and barley stripe rust pan-genome facilitates discovery of the predominant North American lineage's origin in somatic hybridization https://t.co/zxgTLkL74Y
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Wheat and barley stripe rust, caused by Puccinia striiformis formae speciales tritici (Pst) and hordei (Psh) respectively is a perennial and endemic threat to those crops worldwide. Outside the...
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The mycobacterial ATP burst is a lysis artifact and serves as an assay for drug-induced cell wall damage https://t.co/SUbYF4WeIj
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Antibiotics targeting the mycobacterial cell wall are a cornerstone of tuberculosis treatment. Understanding how these drugs facilitate bacterial killing has important implications for identifying...
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Ribosomal protection as a linezolid resistance mechanism in Mycobacterium abscessus https://t.co/DPm5Ui7Yxg
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Mycobacterium abscessus has emerged as a significant pulmonary pathogen characterized by its resistance to most first-line antimycobacterial drugs. Recent investigations have highlighted the clinical...
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A genetically encoded marker for imaging membranes of Plasmodium https://t.co/Geqsy7kDEj
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Fluorescence microscopy is a powerful tool to analyze subcellular architecture, and long-term live-cell imaging permits the analysis of the dynamics of intracellular structures. Applying this...
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Exploring the Repertoire of Rhomboid Proteases in Cryptosporidium parvum Parasite: Phylogenesis, Structural motifs and Cellular ... https://t.co/Hi57OBxyn8
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Cryptosporidium parvum is an apicomplexan parasite and an important pathogen of mammals and humans, which can be infected by zoonotic transmission or directly by human-to-human contacts. This...
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SAMHD1 promotes SARS-CoV-2 infection by enhancing HNF1-dependent ACE2 expression in lung epithelial cells https://t.co/pOLunqpPIe
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Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) restricts a board spectrum of viruses through multifaceted mechanisms. It also limits spontaneous- and virus-induced innate immune...
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Lactate-responsive lysine lactylation in Campylobacter revealed by antibody-based detection of a conserved post-translational ... https://t.co/lJCWljbC87
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Lysine lactylation (Kla) links lactate metabolism to protein regulation yet remains largely unexplored in bacteria. We used a Kla specific rabbit polyclonal anti N L lactyl-lysine antibody to detect...
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