Tristram Ryan
@tristramryan
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Postdoctoral Research Fellow in @Lo_Zanzi lab, @harvardmed @BostonChildrens; Formerly PhD @laoneill111 lab @tcddublin; Sepsis survivor
Joined April 2019
Are you interested in #immunometabolism but not sure where to start?. Introducing our new book “Metabolites as Signals in Immunity and Inflammation”, co-edited with Zbigniew Zasłona (@molecure_sa) and @laoneill111 (@tcddublin), available now. (1/n)
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RT @kjena21: "A simple observation has now become a complete story" — a story about "Life after Death". Thrilled to share our latest work i….
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RT @Lo_Zanzi: #InterferonPower! Thrilled for our latest work @CellCellPress! With @dfrboehmer, we dug into tons of papers & created what we….
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An absolute tour de force on all things interferon. Beautiful new review out now from @dfrboehmer and @Lo_Zanzi.
Immensely honored and excited to share our new review on all things Interferons out now in @CellCellPress. Grateful to the brilliant & inspiring @Lo_Zanzi for the chance to contribute!.Check it out: #InterferonPower @harvardmed @BostonChildrens.
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RT @VinnieViruses: Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mech….
nature.com
Nature - N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal...
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RT @XuZhouLab: Beyond excited to share our #NewPaper in @CellCellPress! Inflamed environments acidify intracellular pH. BRD4 senses this vi….
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RT @Lo_Zanzi: #EpigeneticPower! Our #NewPaper @ImmunityCP shows that endogenous oxidized lipids decide whether host survives or dies during….
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RT @SanchoLab: 💥 A gut microbe metabolite that drives #atherosclerosis?.Yes—Imidazole propionate (ImP) triggers vascular inflammation witho….
nature.com
Nature - Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the...
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We hope you find our new book informative and inspiring for your #immunometabolism studies!. (End).
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Fiachra Humphries @UMass, Jonathan Powell @calico, Emily Day @WesternU, @Lo_Zanzi @BostonChildrens @harvardmed, Doug Green @StJude, @AlexHooftman @EPFL, @Palmer_IMet_lab @Tulane, @AnaDomingosLab @UniofOxford, and contributions from myself, Zbigniew Zasłona and @laoneill111. (4/n).
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With many thanks to all authors for their generous and detailed contributions, and all the team @ElsevierConnect for their support in publishing the book. Our book includes chapters from the labs of Alice Prince @Columbia, @SunnyShinLab and @metaBailism @PennMicro,. (3/n).
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In this new book, we and leaders in the field summarize the recent history of the ever-growing field of immunometabolism, the current state of the field, and future directions including the generation of new therapies harnessing and targeting immunometabolism. (2/n).
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RT @RyanLab_MBU: Methylglyoxal is an antibacterial effector produced by macrophages during infection #immunometabolism..
cell.com
Infected macrophages that transition to aerobic glycolysis produce the reactive aldehyde methylglyoxal. In this study, Anaya-Sanchez et al. use both host and bacterial genetics to show that methylg...
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RT @RyanLab_MBU: Integrated analysis of transcriptional and metabolic responses to mitochondrial stress #mitochondria..
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RT @Lo_Zanzi: #TheMoreTheMerrier! @KPekayvaz Nicolai, Stark &co show @ImmunityCP that non-classical monocytes help to resolve thrombi by re….
cell.com
The immune landscape of human and murine thrombosis remains unclear. Pekayvaz et al. map the immune landscape of thrombosis and describe prominent thrombolytic functions of immune cells, a pattern...
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RT @Lo_Zanzi: #EpigeneticPower! @ivashkivlab Mishra &co show @NatImmunol that anti-inflammatory IL-10 epigenetically silence IRF1 & IRF5 ge….
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RT @thomas_renne: Factor XII drives thrombosis but is dispensable for hemostasis, making it an anticoagulant drug target. We show that fact….
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RT @rogerjspreston: Not sure how useful this site is for recruitment these days, but we are looking to recruit a new postdoc asap to a fund….
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Trained immunity imprints memory to subsequent infections, but it comes with the caveat of lowering the threshold for blood clots 🩸 by upregulating procoagulant tissue factor. Congrats to @AislingRehill, @rogerjspreston, and co on this important discovery. @ScienceAdvances.
Pleased to share our latest paper in @ScienceAdvances on myeloid cell ‘trained hypercoagulability’! 🚀 Project led by @AislingRehill - huge thanks to our collaborators & funders @IrishCtrVascBio @RCSI_Irl @tcddublin @Researchirel @hrbireland @CHIatCrumlin!
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RT @Lo_Zanzi: #EveryCellIsAnImmuneCell! @JieYang437 @RoychoudhuriLab &co show @Nature that platelet-derived thromboxane A2 suppresses T cel….
nature.com
Nature - Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.
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