Xu Zhou (周旭)
@XuZhouLab
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AP @BostonChildrens @harvardmed AM @broadinstitute inflammation, tissue biology, quant.&systems immunology #1stGen #ImmigrantScientists @xuzhoulab.bsky.social
Boston, MA
Joined January 2012
Beyond excited to share our #NewPaper in @CellCellPress! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH
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Many STEM faculty in the country must have felt the same, regardless of whether their funding was terminated. The fact that one’s research funding can be terminated like that without any wrongdoing or lack of productivity from the lab means it could happen to anyone despite any
Harvard researcher Joan Brugge says her work has the potential to prevent breast cancer, but she was notified last spring that her federal funding was terminated. “It was just like a gut punch. My knees buckled, and I had to sit down,” she says.
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Who wants to discuss innate immunity and host defense? Join us in Banff to share your exciting research. https://t.co/0jzZ49WrJG
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#ToPrimeOrNotToPrime, this is the question! Excited to share our new review @TrendsImmuno with Oceane in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! Free link 👇👇👇 https://t.co/iIIPA9lJZn
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Required reading for cell biologists to get a sense of basic statistical principles! https://t.co/tDuww7HCGB
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check out this new work from @Lo_Zanzi on oxPAPC driven NRF2-dependent inflammasome activation!!
#InflammasomePower! How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With Oceane &co we show that chronic oxPAPC signaling drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans!
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We are hiring faculty in Computational Biology (multiple positions) @StJudeResearch. Competitive packages with robust personnel, computing, engineering, and omics-lab/wet-lab support. https://t.co/gFGwlKAYHo
#Hiring #ComputationalBiology #Omics #AI #FacultyJobs
talent.stjude.org
faculty is hiring a Faculty Position - Department of Computational Biology in Memphis, Tennessee. Review all of the job details and apply today!
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Breaking: MIT becomes the first university to reject the Administration’s academic compact - affirming that no agreement should undermine academic freedom or force universities to compromise merit-based science funding.
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Glad that our paper is officially out @CellCellPress. BRD4 condensate functions as a pH sensor to tune inflammatory response in macrophage. https://t.co/Z6GhhU7hQD earlier post: https://t.co/p8sim9ayaq and could-have-been cover by my student&artist Cathleen Krabak @harvardmed
Beyond excited to share our #NewPaper in @CellCellPress! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH
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🚨Excited to see our recent @CellCellPress paper featured in a @lifemetabolism2 preview! Huge thanks to Christoopher Glass @UCSDGlassLab for the thoughtful highlight. 🔗 https://t.co/2gY6vV67DF
#inflammation #macrophage #chromatin #pH #biomolecularcondensates
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Many congrats to all winners and in particular to our own Scott Snapper @BostonChildrens @harvardmed
Please join us in congratulating our 2025 Sherman Prize recipients @MichaelKappel12, Scott Snapper, MD, and @oridamas. @UNC_SOM @UMiamiHealth @umiamimedicine @BostonChildrens @BrighamWomens @harvardmed #gastroenterology #crohns #colitis #IBD
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Coming early 2026: Conference on Gene Expression & Signaling in the Immune System A world-class lineup of interesting and interested scientists will convene at the historic Cold Spring Harbor Lab to discuss all things immunology.
meetings.cshl.edu
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
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Excited to share the first paper from my lab in @Nature ! We repurposed the widely used research tool, proximity labeling, to demonstrate its therapeutic potential in antigen amplification for immunotherapy using mouse tumor models and patient samples. https://t.co/LISBT6GzXB
nature.com
Nature - Red light- or ultrasound-controlled proximity labelling is engineered to stimulate clustering-induced receptor activation and downstream signalling amplification to promote antitumour...
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💥#ImmunometabolismPower! Excited to have this officially out @ImmunityCP💥 Pathogens induce the host to produce oxidized lipids which rewire #macrophage #metabolism, causing #epigenetic modifications which dampen interleukin-10, exacerbating inflammation!
cell.com
Upon pathogen detection, phagocytes trigger immunity. This process induces tissue stress and the formation of host-derived molecules that further tune immune responses. We show that host-derived...
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Another top researcher leaving the US amid research cuts. The comments show how xenophobic haters, none of whom can replace Prof. Liu to do world-leading research in the US, demonize immigrants’ sense of attachment to their heritage and ignore their contributions to this country.
SCMP: Top Harvard mathematician Liu Jun leaves US for China—Patriotism, plus ‘a love for education and science’, amid Trump research cuts, sees leading US statistician Liu Jun return to China https://t.co/eLiZaLIIoI
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Fantastic work from @jkagan1 @BostonChildrens @harvardmed showing NLRP3-based design of new generation of vaccine effective in mice and non-human primates. Huge potential for making potent vaccines to prevent infectious disease and cancer 👏🏼
An NLRP3 stimulatory universal influenza vaccine. We report an NLRP3 stimulus that generates hyperactive dendritic cells (hDCs). https://t.co/oFcCIyyanc
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Fantastic new story @jkagan1 & friends showing that human dendritic cells can become hyperactive activating the inflammasome without dying, & that this approach can be used in mice and NHPs to potentiate anti-influenza vaccine responses! 👇👇👇
An NLRP3 stimulatory universal influenza vaccine. We report an NLRP3 stimulus that generates hyperactive dendritic cells (hDCs). https://t.co/oFcCIyyanc
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Check this out for all interferon lovers! An authoritative review on interferon biology by @Lo_Zanzi!
#InterferonPower! Thrilled for our latest work @CellCellPress! With @dfrboehmer, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free link 👉 https://t.co/gYwGir0npB
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🎉 Congratulations to Dr. Carla Rothlin, incoming Director of CFI, on her election as Vice-President of the International Union of Immunological Societies (IUIS)! A tremendous honor and a testament to her leadership in the global immunology community. 🌍🧪
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The recent cuts to federal mRNA research funding are killing our best chance to cure cancer. Read my OP-ED on this topic in BioSpace, linked below. https://t.co/qDy1leWUI7
biospace.com
The recent announcement of RFK Jr.’s termination of mRNA vaccine contracts is the latest effort to undermine this promising technology at the federal level. Pharmaceutical companies and private...
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👏🏼👏🏼👏🏼
Sometimes the news is actually worth reading. "Senate panel rejects Trump cuts to NIH, other health agencies"
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