Xu Zhou (周旭)
@XuZhouLab
Followers
2K
Following
7K
Media
90
Statuses
2K
AP @BostonChildrens @harvardmed AM @broadinstitute inflammation, tissue biology, quant.&systems immunology #1stGen #ImmigrantScientists @xuzhoulab.bsky.social
Boston, MA
Joined January 2012
Beyond excited to share our #NewPaper in @CellCellPress! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH
16
33
151
Check this out for all interferon lovers! An authoritative review on interferon biology by @Lo_Zanzi!.
#InterferonPower! Thrilled for our latest work @CellCellPress! With @dfrboehmer, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free link 👉
1
2
16
RT @CFI_UMN: 🎉 Congratulations to Dr. Carla Rothlin, incoming Director of CFI, on her election as Vice-President of the International Union….
0
10
0
RT @jkagan1: The recent cuts to federal mRNA research funding are killing our best chance to cure cancer. Read my OP-ED on this topic in B….
biospace.com
The recent announcement of RFK Jr.’s termination of mRNA vaccine contracts is the latest effort to undermine this promising technology at the federal level. Pharmaceutical companies and private...
0
4
0
👏🏼👏🏼👏🏼.
Sometimes the news is actually worth reading. "Senate panel rejects Trump cuts to NIH, other health agencies"
0
0
1
RT @jkagan1: Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflamma….
royalsocietypublishing.org
Damage-associated molecular patterns (DAMPs) are self-derived molecules released during tissue damage that influence immune responses. Phospholipids, essential to cell membranes and lung surfactants,...
0
19
0
RT @Lo_Zanzi: Such an honor and a pleasure to give a lecture at the Advanced Immunology course @ImmunologyAAI. Tons of smart questions, and….
0
3
0
RT @ImmunologyAAI: In his lecture on “Molecular and Cellular Regulation of Inflammation,” Ivan Zanoni (@HarvardMed/@BostonChildrens) explai….
0
4
0
RT @CellCellPress: Now online! Regulation of inflammatory responses by pH-dependent transcriptional condensates
cell.com
BRD4 functions as an intracellular pH sensor through a conserved histidine-rich intrinsically disordered region. Inflammation-associated acidification triggers a pH-dependent switch in transcriptio...
0
28
0
Thanks for highlighting the preprint of our work, now online @CellCellPress
BRD4 acts as a pH sensor to tune inflammation
2
4
16
@RMedzhitov @YaleIBIO @salkinstitute @JRTlab @jkagan1 @Lo_Zanzi @BostonChildrens @harvardmed Thanks for countless long nights @younggouu and epigenetic experts Scott Pope, and all authors👏 Happy to discuss on/off line.
0
0
2
@RMedzhitov @YaleIBIO @salkinstitute @JRTlab @jkagan1 @Lo_Zanzi @BostonChildrens @harvardmed Last but not last, quite uniquely, the pH-sensitive genes seem to have the most recruitment of BRD4 to their enhancers. In another words, BRD4 recruitment might be a predictor of pH-sensitive expression.
1
0
2
@RMedzhitov @YaleIBIO @salkinstitute @JRTlab @jkagan1 @Lo_Zanzi @BostonChildrens @harvardmed 3. surprisingly, we found that only histidine residues in selective regions of BRD4-IDR are required for pH sensitivity, and that consecutive histidine can give rise to pH-sensitivity in biomolecular condensates at physiological pH range.
1
0
2
@RMedzhitov @YaleIBIO @salkinstitute @JRTlab @jkagan1 @Lo_Zanzi @BostonChildrens @harvardmed 2. we added super resolution microscope data to better understand the changes of native BRD4 and MED1 condensates. #STED
1
0
3
@RMedzhitov @YaleIBIO @salkinstitute @JRTlab @jkagan1 @Lo_Zanzi @BostonChildrens @harvardmed A science thread about the preprint version Thanks so much for constructive suggestions from all anonymous reviewers. A couple key updates:.1. Several pH-dependent genes were confirmed at protein level, such as interferon and IL-6.
Super thrilled to share a preprint from the lab We found pH regulates the inflammatory response 🔥in #macrophage by controlling BRD4-dependent transcriptional condensates. In my lab led by @younggouu.
1
0
3
Thanks for the support from @RMedzhitov @YaleIBIO and many people in the lab, and generous help from Diana Hargreaves @salkinstitute @JRTlab @jkagan1 @Lo_Zanzi @BostonChildrens @harvardmed and their teams.
2
0
3
🔥🔥🔥Endogenous oxidized lipids regulate polycomb complex to epigenetically control IL10 level! Congrats to @Lo_Zanzi and Marco! What an amazing discovery👏 honored to play a tiny part in this story 👇
#EpigeneticPower! Our #NewPaper @ImmunityCP shows that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2, blocking #IL10!
1
3
19
RT @Jie_Immunology: My lab is recruiting! We study respiratory immunology, chronic lung diseases and aging. Come join us @UVAimmunology at….
0
23
0
Have been wating for this one: Macrophage derived growth factor promotes epithelial proliferation in the lung and tissue repair under inflammatory damage 🔥🔥🔥 huge congratulation to @RuthFranklinLab @RMedzhitov and the team! 🎉👏🏼🍾
science.org
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the...
3
19
123
RT @slavov_n: Key numbers in cell biology. Having a sense of scale helps to think more rigorously and realistically about biological system….
0
100
0