Roychoudhuri Lab
@RoychoudhuriLab
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Professor of Cancer Immunology and Immunotherapy
University of Cambridge, UK
Joined October 2018
Thrilled to share new work led by @JieYang437 in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre
https://t.co/dO2v0GWKAn
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Wonderful to see Shimon Sakaguchi, Mary E. Brunkow & Fred Ramsdell honoured with the Nobel Prize. From Sakaguchi’s discovery of Treg cells to the identification of Foxp3, their research opened a new chapter in immunology, viewed from the perspective of dominant tolerance.
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The new #ALASCCA RCT shows that low-dose aspirin results in ~50% reduction in metastatic recurrence in patients with PI3K altered colorectal cancer #aspirin #metastasis #prevention
nejm.org
Aspirin reduces the incidence of colorectal adenoma and colorectal cancer among high-risk persons. Observational studies suggest that aspirin may also improve disease-free survival after diagnosis,...
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In patients with localized colorectal cancer and PIK3CA hotspot mutations in exon 9 or 20, daily low-dose aspirin resulted in a significantly lower recurrence rate than placebo. ALASCCA phase 3 trial results: https://t.co/c5FAYCmKwI Editorial: An Aspirin a Day for Improved
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Wonderful to see some fantastic talks at the Department of Medicine Annual Symposium @MedCambridge today
In Session 4 led by Matthew Hoare, we heard from Ayden Case, @Tetsuo_Hase, David Thomas & Emma Hodson. Talks spanned interleukin-2 and atherosclerosis, immune defences at the joint barrier, NK cell biology, and hypoxia in development. @MedCambridge #ResearchDay
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New study alert! Coming out today @ImmunityCP, we describe crosstalk between dysfunctional mitochondria and telomere damage in the context of tumor-induced T cell dysfunction. I'll tell you how we did it: https://t.co/IWtdBxBjr8 1/
cell.com
The functional state of tumor-infiltrating lymphocytes is a critical determinant of antitumor immunity and response to immunotherapy. Rivadeneira et al. demonstrate that mitochondrial ROS accumulat...
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Fantastic 2 days in Lille discussing T cell therapy at CAR T Day - the 9th international symposium on CAR T cells https://t.co/CsP6DR3nbh. Thanks to @at_Mitralab and Ibrahim Yakoub Agha for the invitation to speak
cartday.org
International Symposium on CAR T Cells
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“Dormant cancer cells are like the embers left in an abandoned campfire, and respiratory viruses are like a strong wind that reignites the flames,” describes Dr. DeGregori of @CUAnschutz. Dive deeper with @NIH: https://t.co/AlfQwSrynT
#CancerRecurrence #CancerResearch
nih.gov
A study in mice showed how respiratory viruses could awaken dormant cancer cells.
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A new Science #Immunology study shows that expression of a shortened #FOXP3 variant modifies regulatory T cell function and promotes #antitumor immunity in mouse models. @XiongbinL
https://t.co/9gFGcbVE2W
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Our total energy (electricity) bill for heating and the all other used was £1700 last year! We have described our experience with it here: https://t.co/IG6ueaGIUa Put in a heatpump this summer! You’ll not look back!
sites.google.com
We are a family of four living in a 1930's semi-detached house in Cambridge, UK. Here are the steps we've taken to reduce our ecological footprint.
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Cool to see so many #heatpumps being installed this year. We’ve had our heatpump at home now for 3 years and it’s been saving us money while providing more comfortable heating and reducing our estimated CO2e by 75-80%.
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Please sign this Parliamentary petition calling for comprehensive trade sanctions on Israel - the limited sanctions on specific members of the Israeli Government by the UK do not go far enough:
petition.parliament.uk
We call on the Government to review existing trade ties with Israel, suspend the 2030 Roadmap for UK-Israel bilateral relations and impose trade sanctions upon Israel.
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The mathematics of starvation: how Israel caused a famine in Gaza
theguardian.com
Israel controls the flow of food into Gaza. It has calculated how many calories Palestinians need to stay alive. Its data shows only a fraction has been allowed in
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Hugely well deserved!
I am still in shock and so honored and humbled by the news today! This NAS award is first and foremost for the Kaechians and all their incredible ideas, hard work, and discoveries. Thank you to all my mentors and role models for your support! We all get a gold start today!!
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I am still in shock and so honored and humbled by the news today! This NAS award is first and foremost for the Kaechians and all their incredible ideas, hard work, and discoveries. Thank you to all my mentors and role models for your support! We all get a gold start today!!
We are thrilled to announce the election of 120 members and 24 international members to the National Academy of Sciences in recognition of their distinguished and continued achievements in original research. Congratulations to our new #NASmembers and welcome to the Academy!
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Regev and colleagues describe the role of BACH2 in promoting immunomodulatory Th17 cells. Read it here: https://t.co/D0Tj8mKTQN
https://t.co/eaQ1jI3x7d
nature.com
Nature Immunology - Regulating the balance between TH17 cells that drive autoimmune inflammation and nonpathogenic TH17 cells is critical for limiting autoimmune pathology. Here, the authors...
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Listen to @RFitzgerald_lab in conversation with @TheLancet on their latest paper describing biomarker risk stratification using the #CapsuleSponge in the surveillance of Barrett's oesophagus.
Delighted to be featured on @TheLancet podcast sharing our findings from our recent BE surveillance paper published in the Lancet! Tune in wherever you get your podcasts: https://t.co/NV6weZxEeM
#podcast #surveillance #barretts
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