Thomas Renné
@thomas_renne
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Professor of Clinical Chemistry, MD PhD, fascinated in the crosstalk of coagulation and inflammation, factor XII, polyphosphate, vascular biology
Hamburg, Germany
Joined April 2020
Factor XII drives thrombosis but is dispensable for hemostasis, making it an anticoagulant drug target. We show that factor XII–triggered coagulation traps pathogens and limits bacterial dissemination, highlighting a role of prothrombotic mechanisms in innate immunity.
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Ausschreibung: W2 Professur für Translationale Präzisionsdiagnostik am UKE
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Opportunity for fans of thrombosis and homeostasis. Join our team!
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RT @isth: We regret to share that Claire McLintock (@doctormclintock), passed away on December 23, 2022. Claire served the @ISTH in many po….
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Intrinsic coagulation pathway-mediated thrombin generation in mouse whole blood
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Dec 5, 1994. Russia guaranteers the sovereignty of Ukraine (German news)
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Please enjoy our published article on the mechanistic basis of Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT) and the corresponding commentary in BLOOD #Corona #AstraZeneca.
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It is well known that factor XII has a critical role in thrombosis sparing hemostasis, however the protease has much broader importance. Thanks to Reiner Mailer and colleagues for providing an update on factor XII-driven vascular inflammatory reactions:.
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Mechanism of VITT.In a collaborative effort with Andreas Greinachersr team and many colleagues we have identified the mechanic basis that underlies Vaccine-induced immune thrombotic thrombocytopenia (VITT). The findings will improve patient safety. Enjoy!.
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How clotting starts. Please see our new study on the structure of factor XII activation and its diagnostic implications leading to improved patient care. Enjoy! .
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Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate | Blood | American Society of Hematology
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NETs/Factor XII axis in COVID-19. antibody CSL312 might offer a novel therapy in Corona patients.
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For platelet and coagulation reseacher, please see the new study on platelet polyP:
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