Integrative and Translational Neuroscience Lab
@tendilla_lab
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🔬🧠🐭 Exploring neuroscience. Sharing science and updates from our team @Cinvestav Tlaxcala Lab | PI: @HiramTendilla | #OrgulloCinvestav
Tlaxcala, Mexico
Joined May 2025
🔬🧠🐭 We’re excited to start sharing our work! Exploring neuroscience at @Cinvestav Tlaxcala Lab. Follow along for science, discoveries, and lab updates. #OrgulloCinvestav Learn more about our group:
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The brain neurovascular epigenome and its association with dementia @NeuroCellPress Great study that maps cell-type-specific regulomes showing that small vessel disease heritability spans the neurovascular unit, including astrocytes. These findings helps link vascular risk and
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The neuron–astrocyte metabolic unit as a cornerstone of brain energy metabolism in health and disease:
nature.com
Nature Metabolism - Bolaños and Magistretti illustrate how intercellular metabolic cooperation underpins brain function and provide examples of how disruption of the neuron–astrocyte...
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Functional Genomics Studies of Psychiatric Disorders in Individuals of Latin American Populations: A Scoping Review | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics (AJMGB) https://t.co/errbjUxFbW
onlinelibrary.wiley.com
Over the past 15 years, genetic studies of psychiatric disorders have provided important insight into the contribution of both common variants of small effect, as well as rare exonic and copy number...
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Prelimbic cortex to ventral tegmental area projection regulates early social isolation stress-potentiated heroin seeking in mice | @NatureComms
https://t.co/GEY5XTAaqa
nature.com
Nature Communications - Early life adversity increases addiction vulnerability, but the underlying mechanism is still vague. Here, authors show that early social isolation disrupts the prelimbic...
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Open House at CIRA-UATx/Tlaxcala Lab–@cinvestav 🐭🧠🔬 Today we welcomed Psychotherapy students from UATx! They explored our neurobiology research and met our team, an inspiring day to spark curiosity for basic science and showcase neuroscience in our region #OrgulloCinvestav
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Aging in mice alters regionally enriched striatal astrocytes | @NatureComms
https://t.co/OKBVVfSY6x
nature.com
Nature Communications - Aging drives distinct molecular changes in the brain. Here, the authors use scRNAseq and MERFISH and find that in mice, aging induces subtype-specific, regionally biased...
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Fear protects. Until it doesn’t.: The brain learns to suppress instinctive defensive responses when threats prove harmless https://t.co/vNJ5qTmty8
science.org
The brain learns to suppress instinctive defensive responses when threats prove harmless
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The neuron–astrocyte metabolic unit as a cornerstone of brain energy metabolism in health and disease
nature.com
Nature Metabolism - Bolaños and Magistretti illustrate how intercellular metabolic cooperation underpins brain function and provide examples of how disruption of the neuron–astrocyte...
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Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome, in mice | @NatureCellBio
https://t.co/sDHQ5q9Lkc
nature.com
Nature Cell Biology - Khawaja et al. show sex-specific differences in neuronal-activity regulation by chaperone-mediated autophagy and that loss of chaperone-mediated autophagy leads to defective...
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Now online! Systemic immune activity occurs during human immune system maturation
cell.com
Profiling of immune cells from consecutive developmental time points in second-trimester fetuses and adults reveals that immune activation, immune tolerance, and hematopoiesis occur in a systemic way...
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Cell-type- and locus-specific epigenetic editing of memory expression https://t.co/NHR2HeyIrT
nature.com
Nature Genetics - CRISPR-based epigenetic editing is used in a cell-type-specific, locus-restricted and temporally controllable manner in the adult mouse brain to modulate memory expression.
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The future of neuroscience will be on display at #SfN25's Early Career Poster Session. Experience the next generation of neuroscientists & explore the groundbreaking work that will shape our field for decades to come. Learn more ▶️ https://t.co/dtdlKfATU9
#NeuroTwitter
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Systemic immune activity occurs during human immune system maturation @CellCellPress
https://t.co/0iQXq2jUXX 🇨🇳
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In this recent paper, maternal separation stress produced dysregulated noradrenergic activity in the locus coeruleus (LC) across the lifespan, which disrupted LC regulation of coping strategies in adulthood https://t.co/cjxw81eoHn
nature.com
Neuropsychopharmacology - Maternal separation disrupts noradrenergic control of adult coping behaviors
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Mitochondrial dynamics dysfunction and neurodevelopmental disorders: From pathological mechanisms to clinical translation | @NRRNeural
https://t.co/oaezpj9J2R
journals.lww.com
athological features that may stem from abnormal mitochondrial dynamics and impaired autophagic clearance, which contribute to redox imbalance and oxidative stress in neurons. This review aimed to...
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Albornoz et al. show using advanced imaging techniques that MCC7840—a novel NLRP3 inflammasome inhibitor—reduces neuroinflammation and protects DAergic neurons in preclinical models of PD. https://t.co/LG3cnskeow
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Efficacy and safety of different medications compared for the treatment of postherpetic neuralgia: a network meta-analysis | @FrontPharmacol
https://t.co/JmBGioPn7S
frontiersin.org
BackgroundPostherpetic neuralgia (PHN) is a neuropathic pain and the most common complication of herpes zoster (HZ). Pharmacotherapy serves as the primary in...
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A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging. https://t.co/IBn2bzbzYY
nature.com
Nature Neuroscience - Sheehan et al. have characterized the circadian translatomes of astrocytes and microglia in the mouse cortex in the context of amyloid pathology or aging, revealing cell- and...
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Nature research paper: Integration of hunger and hormonal state gates infant-directed aggression https://t.co/8t7JNzSnWF
nature.com
Nature - Combined behavioural, circuit-level and cellular approaches are used to demonstrate how hypothalamic neurons integrate hunger and oestrous state to drive a switch in how female mice...
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Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA (@enigmabrains) Suicidal Thoughts and Behaviours consortium | @Transl_Psych
https://t.co/C69g0A1wS5
nature.com
Translational Psychiatry - Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium
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